U.S. Department of Health and Human Services

Diabetes: Treatment, Prevention, and Complications

The Diabetes: Treatment, Prevention, and Complications Program supports both basic and clinical studies aimed at addressing the prevention, treatment and pathophysiology of type 1 and type 2 diabetes. Studies on drug development or testing of medical therapies to treat type 1 and type 2 diabetes are included in this program.  Studies specific to type 1 diabetes (T1DM) include those examining the cellular or immunological therapies to induce tolerance or arrest conversion from normal glucose homeostasis or dysglycemia to T1DM. Studies more specific to type 2 diabetes (T2DM) include those examining medical or surgical approaches that prevent diabetes, induce diabetes remission or improve dysglycemia. Studies relevant to both types of diabetes include those proposing lifestyle (diet and exercise) and other behavioral interventions to prevent or treat diabetes, such as approaches to improving health-related behaviors and enhancing diabetes self-management and other aspects of diabetes care.  This Program encompasses basic, clinical and translational research on the pathophysiology and treatment of diabetic complications that apply to multiple tissues and organ systems. It includes tissue-specific research on diabetic wound healing, diabetic neuropathy, and central nervous system impairments including cognition, brain structure and function, resulting from dysglycemia.  The program also includes research on diabetes complications such as hypoglycemia and diabetic ketoacidosis.

 NIDDK Staff

Beena Akolkar, Ph.D.Clinical research in the prevention and immunopathogenesis of Type 1 Diabetes and the genetics and genomics of Type 1 and Type 2 DiabetesAndrew Bremer, M.D., Ph.D.Clinical studies in (1) gestational diabetes and maternal outcomes, and (2) HIV/AIDS-associated metabolic and endocrine dysfunctionCatherine Cowie, Ph.D., M.P.H.Epidemiology of diabetes, including development, control, interventions and complicationsChristine Hunter, Ph.D., ABPPBehavioral research on the prevention and treatment of obesity and diabetes; Centers for Diabetes Translational ResearchTeresa Jones, M.D.Diabetic wound healing, diabetic neuropathy, basic and clinical research of diabetes complications involving multiple organ systems
Christine Lee, M.D., M.S.Clinical studies on the development, diagnosis and medical treatment of type 2 diabetes in adults; clinical studies of diabetes in older adultsPeter J. Savage, M.D.Clinical research in Type 1 and Type 2 Diabetes including secondary analyses; glycemic control and preservation of beta cell functionLuke E Stoeckel, Ph.D.Cognitive and clinical neuroscience of the non-homeostatic (i.e., extra-hypothalamic) contributions to obesity and diabetes and their complicationsKaren L. Teff, Ph.D.Effects of bariatric surgery on diabetes and metabolism, clinical and basic science of hepatic metabolism and hypoglycemia, human sleep and diabetes


 Related Funding Opportunities

Posted DateTitleFull Announcement
10/19/2016Addressing Health Disparities in NIDDK Diseases (R01) (Summary) PA-17-021
10/7/2016BD2K Support for Meetings of Data Science Related Organizations (U13) (Summary) RFA-CA-16-020
8/24/2016Big Data to Knowledge (BD2K) Enhancing the Efficiency and Effectiveness of Digital Curation for Biomedical Big Data (U01) (Summary) RFA-LM-17-001
8/17/2016Identification of Mechanisms Mediating the Effects of Sleep on Diabetes-Related Metabolism in Humans (R01) (Summary) RFA-DK-16-005
8/16/2016Big Data to Knowledge (BD2K) Community-based Data and Metadata Standards Efforts (R24) (Summary) RFA-ES-16-010
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Integrated Islet Distribution Program

The goal of the Integrated Islet Distribution Program (IIDP) is to work with the leading islet isolation centers in the U.S. to distribute high quality human islets to the diabetes research community, in order to advance scientific discoveries and…

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Type 1 Diabetes-Rapid Access to Intervention Development
Type 1 Diabetes-Rapid Access to Intervention Development (T1D-RAID): T1D-RAID is not accepting new applications at this time, but currently supports ongoing projects. The goal of T1D-RAID is to facilitate translation from the lab to the clinic of…

View Additional Research Resources


 NIDDK Active Trials in Diabetes

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.