U.S. Department of Health and Human Services

Diabetic Kidney Disease

The Diabetic Kidney Disease program advances basic research, natural history studies, and clinical trials.  Fundamental research addresses the molecular pathogenesis of podocyte dysfunction, glomerulosclerosis and tubulointerstitial fibrosis.  Also of interest are studies on the role of the renin-angiotensin system, growth factors, eicosanoids, and intracelluar signalling pathways, as well as, causes and effects of renal endothelial cell dysfunction.  The portfolio aims to prevent, reverse, and ameliorate fibrosis.  Specific projects include studies that investigate the mechanisms of fibrosis and use of noninvasive techniques to detect and assess fibrosis (or its severity).  The program also advances studies on discovery of genes that protect people from or predispose them to diabetic nephropathy and identify early markers of increased risk for this disease.​​​​​​​​​

 

 NIDDK Staff

 
Chris Ketchum, Ph.D.Deputy Director, KUH Basic Science; Renal PhysiologyPaul L. Kimmel, M.D.Clinical AKI; Kidney Translational Genetics; Kidney Centers; Kidney HIV/AIDS
Krystyna Rys-Sikora, Ph.D.AKI and CKD Pathobiology

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
1/5/2017Research on the Health of Women of Underrepresented, Understudied and Underreported (U3) Populations An ORWH FY17 Administrative Supplement (Admin Supp) (Summary) PA-17-101
12/23/2016Administrative Supplements for Research on Sexual and Gender Minority (SGM) Populations (Admin Supp) (Summary) PA-17-098
12/15/2016Limited Competition: Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4) (Summary) RFA-DK-16-504
12/14/2016Therapeutic Targeting Of The Human Islet Environment (UC4) (Summary) RFA-DK-17-003
12/14/2016Competitive Collaborative Projects for Human Islet Biology (UC4) (Summary) RFA-DK-17-004
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Mouse Metabolic Phenotyping Centers

The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.

Integrated Islet Distribution Program

The goal of the Integrated Islet Distribution Program (IIDP) is to work with the leading islet isolation centers in the U.S. to distribute high quality human islets to the diabetes research community, in order to advance scientific discoveries and…

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…

View Additional Research Resources

 

 NIDDK Active Trials in Diabetes

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.