The Diabetic Kidney Disease program advances basic research, natural history studies, and clinical trials. Fundamental research addresses the molecular pathogenesis of podocyte dysfunction, glomerulosclerosis and tubulointerstitial fibrosis. Also of interest are studies on the role of the renin-angiotensin system, growth factors, eicosanoids, and intracelluar signalling pathways, as well as, causes and effects of renal endothelial cell dysfunction. The portfolio aims to prevent, reverse, and ameliorate fibrosis. Specific projects include studies that investigate the mechanisms of fibrosis and use of noninvasive techniques to detect and assess fibrosis (or its severity). The program also advances studies on discovery of genes that protect people from or predispose them to diabetic nephropathy and identify early markers of increased risk for this disease.