U.S. Department of Health and Human Services

Digestive Diseases Clinical Research and Epidemiology

The Digestive Diseases Clinical Research and Epidemiology program supports patient-oriented clinical research and epidemiology research in digestive diseases.  The program supports small clinical studies focused on research that is innovative and of potential high impact and should lead to full-scale clinical trials.  The program encourages Phase III clinical trials, which are typically multi-center and involve several hundred patients randomized to two or more treatments, one of which is usually a placebo.  The aim of such trials is to provide evidence for support of, or a change in, health policy or standard of care.  Studied treatments may include pharmacologic, nonpharmacologic, and behavioral interventions for disease prevention, prophylaxis, diagnosis, or therapy.  The program’s research portfolio includes studies on:  Helicobacter pylori; inflammatory bowel disease; functional bowel disorders and constipation; nonulcer dyspepsia; celiac disease; intestinal failure; short gut syndrome; and small bowel transplantation.
 
This program also serves as a focal point for the collection, analysis, and dissemination of data on digestive diseases and their complications.  The program encourages research that addresses risk factors for disease occurrence and disease prognosis or natural history.  The program also supports databases and biological repositories that advance clinical and epidemiological studies in digestive diseases and nutrition.  Specific areas of focus for this program include:  identifying the data needed to address the scientific and public health issues in digestive diseases and nutrition; addressing the epidemiology of digestive diseases and nutritional disorders of public health significance, with particular emphasis on national surveys and their follow-up; promoting the timely availability of reliable data to pertinent scientific, medical, and public organizations; standardizing data collection and terminology in clinical and epidemiological research; and working closely with members of the scientific community to develop investigator-initiated research in digestive diseases and nutrition epidemiology.
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 NIDDK Staff

 
Dana K. Andersen, M.D.Frank Hamilton, M.D., M.P.H.Gastrointestinal and Nutrition AIDS; Gastrointestinal Endoscopy Research; Gastrointestinal Mucosa and Immunology; Gastrointestinal MotilityDavid Saslowsky, Ph.D.Career Development Programs (K awards)
Jose Serrano, M.D., Ph.D.Gastrointestinal Neuroendocrinology; Exocrine Pancreas; Pancreatitis Aynur Unalp-Arida M.D., M.Sc., Ph.D.Epidemiology, Clinical Trials, Digestive Diseases, and Nutrition

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
7/21/2016Assay Development and Screening to Discover Therapeutic or Imaging Agents for Diseases of Interest to the NIDDK (R01) (Summary) PA-16-374
7/20/2016Promoting Organ and Tissue Donation Among Diverse Populations (R01) (Summary) RFA-DK-16-022
6/9/2016Administrative Supplements for Research on Dietary Supplements (Admin Supp) (Summary) PA-16-319
6/3/2016PHS 2016-02 Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) (Summary) PA-16-302
6/3/2016PHS 2016-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]) (Summary) PA-16-303
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Inflammatory Bowel Disease Genetic Consortium

The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) consists of investigators from seven sites in the U.S. and Canada, who have recruited a large sample of inflammatory bowel disease patients, their relatives, and control subjects. All…

Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Predicting Response to Standardized Pediatric Colitis Therapy

The mission of the PROTECT Study is to provide a better understanding of how children newly diagnosed with ulcerative colitis (UC) respond to mesalamine and prednisone (corticosteroid), the standard initial therapies used to treat this disorder…

Intestinal Stem Cell Consortium

The mission of the ISCC is to advance the understanding of intestinal epithelial stem cell biology during development, homeostasis, regeneration and disease. The immediate goals of the ISCC are to isolate, characterize, culture and validate…

Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

View Additional Research Resources

 

 NIDDK Active Trials in Digestive Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.
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NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the​ ​​NIH Common Fund.​