U.S. Department of Health and Human Services

Endocrinology and Hormone Signaling

The Endocrinology and Hormone Signaling program supports basic and clinical research on endocrinology, neuroendocrinology, hormone signaling, and nutrient sensing—with an emphasis on developing mechanistic insights into diabetes, obesity, and other endocrine-related health problems.  Studies include those that address the regulation of body composition; interactions between nutrition, exercise, and anabolic hormones; neural pathways and neuropeptides that regulate feeding behavior, satiety, and energy expenditure; the function and interaction of the hypothalamic-pituitary axis with peripheral metabolic signals;  the hormonal regulation of bone and mineral metabolism in health and disease; and the impact of metabolic derangements in type 1 and type 2 diabetes mellitus on the skeleton. Other studies address the structure and function of nuclear receptors and co-regulators and their regulation of gene expression; cellular mechanisms of glucose regulation; the intracellular signals that regulate cellular responses to insulin and other hormones; and the mechanisms and signaling pathways involved in nutrient sensing.  These studies are aimed at demonstrating how disruption of the pathways leads to the onset and/or progression of metabolic disease.​​​​​​​​​​​​​​​

 

 NIDDK Staff

 
Carol Renfrew Haft, Ph.D.Adipocyte development and biology in various fat depots; protein trafficking, secretion, processing and ER stress in metabolic diseaseJames F. Hyde, Ph.D.Neurobiology of energy balance and body composition in obesity; Diabetes Research Centers
Saul Malozowski, M.D., Ph.D., M.B.A.Neuroendocrinology of hypothalamic-pituitary axis, neuropeptide signaling and receptors; hormonal regulation of bone and mineral metabolismCorinne M. Silva, Ph.D.Signaling pathways, nuclear receptors and nutrient sensing in metabolic tissues; role of intrauterine environment in offspring metabolic disease

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
1/17/2017Biomarkers for Diabetes, Digestive, Kidney and Urologic Diseases Using Biosamples from the NIDDK Repository (R01) (Summary) PAR-17-123
1/5/2017Research on the Health of Women of Underrepresented, Understudied and Underreported (U3) Populations An ORWH FY17 Administrative Supplement (Admin Supp) (Summary) PA-17-101
12/23/2016Administrative Supplements for Research on Sexual and Gender Minority (SGM) Populations (Admin Supp) (Summary) PA-17-098
12/15/2016Limited Competition: Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4) (Summary) RFA-DK-16-504
12/14/2016Therapeutic Targeting Of The Human Islet Environment (UC4) (Summary) RFA-DK-17-003
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Mouse Metabolic Phenotyping Centers

The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.

Integrated Islet Distribution Program

The goal of the Integrated Islet Distribution Program (IIDP) is to work with the leading islet isolation centers in the U.S. to distribute high quality human islets to the diabetes research community, in order to advance scientific discoveries and…

Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit

The GLND trial is a multi-center, double-blind, placebo-controlled, intent-to-treat Phase III trial, designed to determine the effect of parenteral glutamine (GLN) dipeptide on important clinical outcomes in patients requiring surgical intensive care…

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…

View Additional Research Resources

 

 NIDDK Active Trials in Endocrine Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.