U.S. Department of Health and Human Services

Gastrointestinal Physiology, Development, and Epithelial Biology

The Gastrointestinal (GI) Physiology, Development, and Epithelial Biology program supports basic and translational research on the development, structure, and function of the GI tract in health and disease.  This program focuses on GI development, regeneration, and healing, including the role of gastrointestinal stem cells and stem cell differentiation; basic biology of the GI epithelium, including studies on the structure and function of the epithelium, interactions between the epithelium and other components of the GI tract, and the integrity of the epithelium as a barrier; the cellular and molecular mechanisms regulating transport and absorption of water, ions, sugars, amino acids/peptides, lipids, vitamins, and minerals across the epithelium; requirements, bioavailability, and metabolism of nutrients and other dietary components at the organ, cellular, and subcellular levels in normal and diseased states; gut barrier function and permeability and normal and abnormal function of the enteric nervous system, including the structure and function of GI hormones peptides and bile acid metabolism.​​​​​​​​​​​​​​​​​​​ Also of interest are studies that explore the role of taste receptors in the GI tract in nutrient absorption and other metabolic functions.​ ​​

 

 NIDDK Staff

 
Jill L. Carrington, Ph.D.Basic Neurogastroenterology; Gastrointestinal Development, Epithelial Biology, Stem Cell BiologyPatricia Greenwel, Ph.D.Basic Neurogastroenterology; Gastrointestinal Development, Epithelial Biology, Stem Cell BiologyPadma Maruvada, Ph.D.Nutrient Metabolism; Clinical Obesity and Nutrition
Peter Perrin Ph.D.Gastrointestinal Host-Microbial Interactions, Basic Mucosal Immunology and InflammationDavid Saslowsky, Ph.D.Career Development Programs (K awards)Jose Serrano, M.D., Ph.D.Gastrointestinal Neuroendocrinology; Exocrine Pancreas; Pancreatitis

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
11/25/2016Limited Competition: Research Resource for Human Organs and Tissues (U42) (Summary) RFA-OD-17-001
11/23/2016NIH Health Care Systems Research Collaboratory - Demonstration Projects for Pragmatic Clinical Trials (UG3/UH3) (Summary) RFA-RM-16-019
10/27/2016NIDDK Exploratory Clinical Trials for Small Business (R44) (Summary) PAR-17-034
10/19/2016Addressing Health Disparities in NIDDK Diseases (R01) (Summary) PA-17-021
10/11/2016Microphysiological Systems (MPS) for Disease Modeling and Efficacy Testing (UG3/UH3) (Summary) RFA-TR-16-017
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Inflammatory Bowel Disease Genetic Consortium

The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) consists of investigators from seven sites in the U.S. and Canada, who have recruited a large sample of inflammatory bowel disease patients, their relatives, and control subjects. All…

Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Predicting Response to Standardized Pediatric Colitis Therapy

The mission of the PROTECT Study is to provide a better understanding of how children newly diagnosed with ulcerative colitis (UC) respond to mesalamine and prednisone (corticosteroid), the standard initial therapies used to treat this disorder…

Intestinal Stem Cell Consortium

The mission of the ISCC is to advance the understanding of intestinal epithelial stem cell biology during development, homeostasis, regeneration and disease. The immediate goals of the ISCC are to isolate, characterize, culture and validate…

Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium

The goal of this follow-up study of mothers who participated in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study, is to determine the levels of blood sugar during pregnancy that are linked to increased body fat in the child, and to a…

View Additional Research Resources

 

 NIDDK Active Trials in Gastrointestinal Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.

NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the​ ​​NIH Common Fund.​