U.S. Department of Health and Human Services

Neurobiology of Obesity

The Neurobiology of Obesity program encompasses research on the regulation of body composition by circulating factors.  Specific areas of support comprise the endocrinology of body composition, including interactions between nutrition, exercise, and anabolic hormones; neuropeptides and their receptors involved in regulatory pathways controlling feeding behavior, satiety, and energy expenditure; interactions between the hypothalamic-pituitary-adrenal axis and peripheral metabolic signals (e.g., insulin, leptin, glucocorticoids, ghrelin); the hypothalamic integration of peripheral endocrine and metabolic signals; regulatory networks controlling food intake and energy balance; and the ontogeny of neuronal networks related to obesity.​​​​​​​​​​​​​​

 

 NIDDK Staff

 
James F. Hyde, Ph.D.Neurobiology of energy balance and body composition in obesity; Diabetes Research Centers
Luke E Stoeckel, Ph.D.Cognitive and clinical neuroscience of the non-homeostatic (i.e., extra-hypothalamic) contributions to obesity and diabetes and their complications

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
11/25/2016Limited Competition: Research Resource for Human Organs and Tissues (U42) (Summary) RFA-OD-17-001
11/23/2016NIH Health Care Systems Research Collaboratory - Demonstration Projects for Pragmatic Clinical Trials (UG3/UH3) (Summary) RFA-RM-16-019
10/27/2016NIDDK Exploratory Clinical Trials for Small Business (R44) (Summary) PAR-17-034
10/25/2016Circadian Mechanisms Contributing to Obesity, Diabetes Metabolism, and Underlying Heart, Lung, and Blood Disorders (R01) (Summary) RFA-HL-17-020
10/19/2016Addressing Health Disparities in NIDDK Diseases (R01) (Summary) PA-17-021
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Mouse Metabolic Phenotyping Centers

The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
Lifestyle Interventions for Expectant Moms

LIFE-Moms is a consortium comprised of seven clinical centers, a Research Coordinating Unit and NIH program staff.  The overall goal of the Consortium is to identify effective behavioral and lifestyle interventions that will improve weight, glycemic…

View Additional Research Resources

 

 NIDDK Active Trials in Obesity Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
​Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.

NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the​ ​​NIH Common Fund.​