U.S. Department of Health and Human Services

Pancreas Basic Research and Development

The Pancreas Basic Research and Development program supports research on the structure, function, and diseases—excluding cancer and cystic fibrosis—of the exocrine pancreas.  Specific projects examine the hormonal and neural regulation of electrolyte, fluid, and enzyme secretion; receptors for secretagogues; and stimulus-secretion coupling mechanisms.  Also of interest are studies of gut-islet-acinar interrelations; organization and expression of pancreatic genes; and protein synthesis and export.

The program encourages work that advances our understanding of tissue injury, repair, and regeneration; the physiology and pathology of trophic responses; neural innervation; and transcapillary solute and fluid exchange. Information about pancreatic development has led to insights regarding nuclear transcription factors and signaling pathways regulating pancreatic progenitor/precursor cell expansion and differentiation.  The identification and characterization of progenitor cells that can support expansion of ductal/exocrine cell populations destroyed during acute or chronic pancreatitis, or pancreatic cancer, and factors that control differentiation of the descendants of these progenitors--along with a more complete understanding of the normal pancreas at each stage of development--is essential for future advances in detecting, preventing, and treating these diseases.​​​​​​​​​​​​​​


 NIDDK Staff

Jose Serrano, M.D., Ph.D.Gastrointestinal Neuroendocrinology; Exocrine Pancreas; Pancreatitis; Drug Induced Liver Injury; Clinical Research on GI Diseases


 Related Funding Opportunities

Posted DateTitleFull Announcement
1/5/2017Research on the Health of Women of Underrepresented, Understudied and Underreported (U3) Populations An ORWH FY17 Administrative Supplement (Admin Supp) (Summary) PA-17-101
12/23/2016Administrative Supplements for Research on Sexual and Gender Minority (SGM) Populations (Admin Supp) (Summary) PA-17-098
12/21/2016Academic-Industrial Partnerships to Translate and Validate in vivo Cancer Imaging Systems (R01) (Summary) PAR-17-093
12/12/2016Administrative Supplement for Research on Sex/Gender Influences (Admin Supp) (Summary) PA-17-078
12/8/2016Limited Competition: Revision Application for the Human Islet Research Network Coordinating Center (U01) (Summary) RFA-DK-17-501
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The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.


 Research Resources

Resource NameDescription
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…
NIDDK Information Network

The NIDDK Information Network (dkNET), serves the needs of basic and clinical investigators by providing seamless access to large pools of data relevant to the mission of NIDDK. The goal of dkNET is to develop a community-based network for…

NIDDK Repository for Biosamples and Data

Supports Data, Biosample, and Genetic Repositories to increase the impact of current and previously funded NIDDK studies by making their data and biospecimens available to the broader scientific community. These Repositories enable scientists not…

Type 1 Diabetes TrialNet

Type 1 Diabetes TrialNet (TrialNet) is an international network of researchers who are exploring ways to prevent, delay and reverse the progression of type 1 diabetes.

Study of Nutrition in Acute Pancreatitis

SNAP is a randomized multi-center clinical trial designed to test whether duodenojejunal (DJ) feeding is more effective than nasogastric (NG) feeding in providing enteral nutrition to patients with severe acute pancreatitis. SNAP will enroll…

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 NIDDK Active Trials in Pancreatic Disease

View related clinical trials from ClinicalTrials.gov.


 Related Study Sections

Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.​