U.S. Department of Health and Human Services

Pathophysiology of Diabetes and Metabolic Disease

The Pathophysiology of Diabetes and Metabolic Disease Program supports basic and clinical research that addresses the pathophysiology of metabolic diseases, including type 1 and type 2 diabetes. This Program also includes studies that address the etiology of type 1 diabetes and other autoimmune endocrine diseases, such as autoimmune thyroid disease.

This Program supports both basic mechanistic and clinical studies that address the effect of the intrauterine environment on subsequent metabolic disease in the offspring, as well as the role of gestational diabetes on the subsequent development of maternal diabetes. Also included are studies that use innovative technologies, such as genetic and epigenetic analyses, systems biology, and bioengineering, to understand the biological networks of underlying disease, with the goal of developing novel therapeutic strategies.​​​

 

 NIDDK Staff

 
Kristin M. Abraham, Ph.D.The role of inflammation in the pathophysiology of metabolic disease and the use of mouse models in metabolic phenotypingOlivier Blondel, Ph.D.Pathophysiology of the endocrine pancreas in diabetes; technology development (i.e. genomics and systems biology) in metabolic diseaseAndrew Bremer, M.D., Ph.D.Clinical studies in (1) gestational diabetes and maternal outcomes, and (2) HIV/AIDS-associated metabolic and endocrine dysfunctionChristine Lee, M.D., M.S.Clinical studies on the development, diagnosis and medical treatment of type 2 diabetes in adults; clinical studies of diabetes in older adults
Barbara Linder, M.D., Ph.D.Type 2 diabetes in children and youth; medical management of type 1 diabetes in children, youth and adults; human studies of metabolic imprintingCorinne M. Silva, Ph.D.Signaling pathways, nuclear receptors and nutrient sensing in metabolic tissues; role of intrauterine environment in offspring metabolic diseaseLisa M. Spain, Ph.D.Etiology and pathogenesis of type 1 diabetes and other autoimmune endocrine diseasesKaren L. Teff, Ph.D.Effects of bariatric surgery on diabetes and metabolism, clinical and basic science of hepatic metabolism and hypoglycemia, human sleep and diabetes

 

 Related Funding Opportunities

 
Posted DateTitleFull Announcement
12/5/2016Limited Competition: Data Coordinating Center for Type 1 Diabetes TrialNet (UC4) (Summary) RFA-DK-16-505
12/1/2016Limited Competition: Continuation of the Preventing Early Renal Loss in Diabetes (PERL) Study (UC4) (Summary) RFA-DK-16-506
11/25/2016Limited Competition: Research Resource for Human Organs and Tissues (U42) (Summary) RFA-OD-17-001
11/23/2016NIH Health Care Systems Research Collaboratory - Demonstration Projects for Pragmatic Clinical Trials (UG3/UH3) (Summary) RFA-RM-16-019
11/7/2016Coordinating Unit for the Mouse Metabolic Phenotyping Centers (U24) (Summary) RFA-DK-16-034
View More Funding Opportunities

The resources listed below include reagents, data, protocols, etc. If you would like to utilize any of these resources, contact the person associated with the resource.

 

 Research Resources

 
Resource NameDescription
Mouse Metabolic Phenotyping Centers

The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.

Integrated Islet Distribution Program

The goal of the Integrated Islet Distribution Program (IIDP) is to work with the leading islet isolation centers in the U.S. to distribute high quality human islets to the diabetes research community, in order to advance scientific discoveries and…

Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study
ACCORDION (sponsored by NHLBI) is a prospective, observational follow-up study of at least 8000 participants who were treated and followed in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial.  Treatment in ACCORD ended in 2009 and…
Action for Health in Diabetes
Look AHEAD is a 16-center, randomized clinical trial investigating the long-term health effects of an intensive lifestyle intervention designed to produce weight loss. Look AHEAD enrolled 5,145 overweight or obese participants with type 2 diabetes…
Diabetic Complications Consortium
The goal of the NIDDK-sponsored Diabetic Complications Consortium (DiaComp) is to foster communication and collaboration between investigator communities involved in complications research.  Toward this goal, DiaComp: (1) sponsors annual meetings in…

View Additional Research Resources

 

 NIDDK Active Trials in Diabetes and Metabolic Disease

 
View related clinical trials from ClinicalTrials.gov.

 

 Related Study Sections

 
Study sections conduct initial peer review of applications in a designated scientific area. View related study sections from the NIH's Center for Scientific Review.​

NIH Common Fund

Learn about current projects and view funding opportunities sponsored by the​ ​​NIH Common Fund.​