The Urology Genetics and Genomics program focuses on research that uses genetic and genomic approaches to understand the normal and pathologic functions of the urinary and urogenital tracts. It includes studies seeking to elucidate the heritability or molecular genetic basis of single-gene or genetically complex familial diseases in humans. This work includes studies that identify and characterize quantitative trait loci or modifier loci affecting single-gene traits in humans or animal models. The program advances studies of mutagenesis and mutant screens and genotype-phenotype correlations.
The research portfolio also includes work to develop statistical techniques for mapping genes contributing to complex traits. Program-supported researchers may also develop high-throughput genomic and proteomic technologies and genomic tools for the creation of transgenic or knockout animals.