1. Home
  2. Research and Funding
  3. Technology Advancement & Transfer
  4. Research Materials & Licensing
  5. Adenovirus gene expression system (U.S. Patent Number 6,824,770)

Adenovirus gene expression system (U.S. Patent Number 6,824,770)

The invention is directed to an adenoviral vector comprising (a) at least one insertion site for cloning a heterologous gene, and, in an orientation opposite to the direction of transcription of the adenoviral region into which it is inserted, (b) a heterologous promoter positioned upstream from the insertion site, (c) a eukaryotic splice acceptor and splice donor site positioned between the promoter and the insertion site; and (d) a polyadenylation sequence positioned downstream of the insertion site. The invention also provides a host cell infected with such a vector, a method of producing a selected protein, and a method of delivering a heterologous gene to an animal heart.

Resource Details

tao@niddk.nih.gov

Gershengorn, Marvin

Share