Event Details
Agenda
Event Details
Background
The Congenital Anomalies of External Genitalia Workshop will be held on May 31st and June 1st, 2018 at the AUA Headquarters in Linthicum, MD. This two-day meeting will bring together researchers from a range of disciplines, including pediatric urology, developmental biology, genetics & genomics, computational biology, endocrinology, and epidemiology, with the goal of advancing basic and clinical research in hypospadias and related disorders of external genital development. Presentations and roundtable discussions of current research strategies will aim to identify key knowledge gaps and missed opportunities, and to develop potential investigative solutions that will address deficiencies in the field. Basic and clinical researchers interested in the causes of hypospadias and related congenital anomalies of external genitalia are encouraged to attend.
Organizing Committee
Caroline Best, Ph.D., American Urological Association
Martin. J. Cohn, Ph.D., University of Florida College of Medicine
Deborah Hoshizaki, Ph.D., NIDDK
Craig Peters, M.D., University of Texas Southwestern Medical Center
H. Scott Stadler, Ph.D., Shriners Hospital for Children–Portland
Registration Deadline
May 23, 2018
Agenda
May 31, 2018
- 8:30 a.m. – 8:40 a.m.
- Welcome
Robert Star, M.D., Director, Division of Kidney, Urologic, & Hematologic Diseases, NIDDK
- 8:40 a.m. – 9:00 a.m.
- Defining the future of congenital penile anomaly research
Craig Peters, M.D., UT Southwestern
Session 1. External genital anomalies in humans: views from the clinic
- 9:00 a.m. – 9:30 a.m.
- Refining the broad category of “hypospadias” into specific anomalies rooted in developmental causes.
Larry Baskin, M.D., UCSF
- 9:30 a.m. – 10:00 a.m.
- Translational research approaches to congenital anomalies of the genitalia
Linda Baker, M.D., UT Southwestern
- 10:00 a.m. – 10:30 a.m.
- Discussion – How to leverage clinical samples
Deborah Hoshizaki, Ph.D., NIDDK
- 10:30 a.m. – 11:00 a.m.
- Break
Session 2. Genetics of external genitalia development in model systems
- 11:00 a.m. – 11:30 a.m.
- Roles of Wnt signaling in external genital development
Liang Ma, Ph.D., Washington University
- 11:30 a.m. – 12:00 p.m.
- Roles of gene-environment interactions in development of external genital anomalies
Marty Cohn, Ph.D., University of Florida
- 12:00 p.m. – 12:30 p.m.
- Sexually dimorphic utilization of gene regulatory elements during development of external genitalia
Sean Li, Ph.D., Harvard University
- 12:30 p.m. – 1:30 p.m.
- Lunch
- 1:30 p.m. – 2:00 p.m.
- Epigenetic control of penile development by LncRNAs
H. Scott Stadler, Ph.D., Shriners Hospital
Session 3. Genetics & Genomics of Congenital Anomalies of External Genitalia
- 2:00 p.m. – 2:30 p.m.
- Genetic control of urethral tube closure
Andrew Pask, Ph.D., University of Melbourne
- 2:30 p.m. – 3:00 p.m.
- Genetics of human disorders of sex development
Eric Vilain: M.D., Ph.D., Children's National Medical Center & George Washington University
- 3:00 p.m. – 3:30 p.m.
- Break
- 3:30 p.m. – 4:00 p.m.
- Insights into the pathology of human hypospadias through genome analysis
Dolores Lamb, Ph.D., Weill Cornell Medical College
- 4:00 p.m. – 4:30 p.m.
- Epidemiology and genetics of hypospadias in Denmark
Frank Geller, M.D., Statens Serum Institut, Copenhagen
- 4:30 p.m. – 7:00 p.m.
- Breakout sessions Day 1
- 7:00 p.m.
- End of day 1
June 1, 2018
Session 4. The role of endocrine disruption in hypospadias
- 8:30 a.m. – 9:00 a.m.
- Effects of endocrine disrupting chemicals on genitourinary development
L. Earl Gray, Ph.D., U.S. EPA
- 9:00 a.m. – 9:30 a.m.
- Systems modeling and predictive toxicology of external genital development
Tom Knudsen, Ph.D., U.S. EPA
Session 5: Epidemiology of external genital defects
- 9:30 a.m. – 10:00 a.m.
- Epidemiologic analysis of congenital anomalies of external genitalia
Victoria Bird, M.D., University of Florida
- 10:00 a.m. – 10:30 a.m.
- Prevalence trends and geospatial analysis of hypospadias, cryptorchidism, and non-endocrine mediated congenital anomalies
Rodrigo Romao, M.D., Dalhousie University
- 10:30 a.m. – 11:00 a.m.
- Break
Session 6. Applied technologies to study congenital anomalies of the external genitalia
- 11:00 a.m. – 11:30 a.m.
- The accessible chromatin landscape at single-cell resolution
Andrew Adey, Ph.D., Oregon Health and Science University
- 11:30 a.m. – 12:00 p.m.
- Single cell genomics to understand complex cell lineages during development
Spyros Darmanis, Ph.D., Chan Zuckerberg Biohub
Session 7. Development of a Centralized Biobank
- 12:00 p.m. – 12:30 p.m.
- Next Generation Biobanks: tissues, live cells, and DNA for investigation of the congenital anomalies of external genitalia
Roundtable discussion
- 12:30 p.m. – 2:00 p.m.
- Breakout sessions with lunch
- 2:00 p.m. – 3:00 p.m.
- General Discussion: Reports from breakout session leaders
- 3:00 p.m.
- Adjourn
- 3:30 p.m. – 6:00 p.m.
- Writing Team Assemble
