Advances in Acute and Chronic Pancreatitis: From Development to Inflammation and Repair

June 25 - 26, 2012 Contacts

Event Details Agenda

Meeting Objectives

To enhance our understanding of pancreatic developmental and stem cell biology; pancreatitis (acute and chronic); genetics of pancreatitis; the link between the inflammatory pancreatic microenvironment and neoplasia; and pancreatic neurobiology
To identify new strategies in diagnosis, imaging, and therapy of pancreatitis
To foster collaborative and innovative interdisciplinary translational research
To coalesce the meeting findings into a publication as a roadmap for future National Institutes of Health (NIH) based initiatives

7:30 a.m.: Registration
8:00 a.m.: Welcome
Stephen James, M.D., and Jane Holt
8:10 a.m.: Acute Pancreatitis: The View From the 21st Century
Albert B. Lowenfels, M.D.
8:30 a.m.

Chair: Matthias Hebrok, Ph.D.

Cell Plasticity in the Pancreas in Development and Disease
Maike Sander, M.D.; Acinar Development and Transcriptional Regulatory Networks
Ray MacDonald, Ph.D.; Tips, Trunks, and In-between - Development of Pancreatic Duct and Centroacinar Cells
Steven Leach, M.D.
9:15 a.m.: Panel Discussion
9:45 a.m.: Break
10:00 a.m.

Chair: Ben Stanger, M.D., Ph.D.

Pancreatic Stem Cells
Derek van der Kooy, Ph.D.; Molecular Mechanisms of Pancreatic Regeneration
Roland Schmid, M.D.; Identifying Signals and Lineages That Control Pancreatic Regeneration
Charles Murtaugh, Ph.D.; Exploiting Acute Experimental Pancreatitis Models to Identify Novel Genes Involved in Exocrine Physiology and Pancreatic Cancer
Francisco X. Real, M.D., Ph.D.
11:00 a.m.: Panel Discussion
11:30 a.m.

Chair: Marina Pasca di Magliano, Ph.D.

Utilizing Proteomics to Understand Acute Pancreatitis
John Williams, M.D., Ph.D.; Environmental Factors and Protein Processing in the Endoplasmic Reticulum of the Acinar Cell Stephen Pandol, M.D.; Signaling Pathways, Pancreatitis, and the Microenvironment
Matthias Hebrok, Ph.D.; Mouse Models of Pancreatitis
Craig Logdson, Ph.D.
12:30 p.m.: Panel Discussion
1:00 p.m.: Lunch
2:00 p.m.

Chair: Steven Freedman, M.D., Ph.D.

Conditional Knockout Mouse Models to Identify Genotype-phenotype Interactions
Mitchell Drumm, Ph.D.; Genetic Approaches Common to All Pancreatic Diseases
Peter Durie, M.D.; Novel Strategies to Identify Candidate Genes Using Exomic Sequencing Using Renal Disease as an Example
Martin Pollak, M.D.; Chymotrypsin C in Hereditary and Sporadic Chronic Pancreatitis
Miklos Sahin-Toth, M.D., Ph.D.
3:00 p.m.: Panel Discussion
3:30 p.m.: Break
3:45 p.m.

Chair: Ashok Saluja, Ph.D.

Role of Stellate Cells in Alcoholic Pancreatitis
Minoti Apte, Ph.D., M.D.; Treatment and Prevention Strategies in Acute Pancreatitis
Bechien Wu, M.D., M.P.H.; The Role of Proteases in Pancreatitis
Markus Lerch, M.D.
4:45 p.m.: Panel Discussion
5:15 p.m.: Adjournment

Chair: Chris Forsmark, M.D.

Current and Future Strategies for Early Diagnosis
Darwin Conwell, M.D., M.S.; Chronic Pancreatitis: Relevance of Animal Models to Human Disease
Fred Gorelick, M.D.; Environmental and Non-genetic Risk Factors for Chronic Pancreatitis
Dhiraj Yadav, M.D., M.P.H.; Framing the Critical Problems of Chronic Pancreatitis
David Whitcomb, M.D.
9:15 a.m.: Panel Discussion
9:45 a.m.: Break
10:00 a.m.

Chair: P. Jay Pashrica, M.D.

Clinical Needs
Michael Levy, M.D.; Molecular Mechanisms of Pain in Chronic Pancreatitis
P. Jay Pashrica, M.D.; Neurogenic Pancreatitis
Rodger Liddle, M.D.; The Neural Microenvironment in the Pancreas
Gustavo Ayala, M.D.
11:00 a.m.: Panel Discussion
11:35 a.m.: Closing Remarks
Anil Rustgi, M.D.
12:00 p.m.: Adjournment

Lister Hill Auditorium
Building 38A, NIH Campus
Bethesda, MD 20892

Program Contact
Jose Serrano M.D., Ph.D.
NIDDK/NIH
T: 301-594-8871

Sherry Brown, M.S.
NIDDK/NIH
T: 301-435-8150

Meeting Logistics
Michelle Watson
The Scientific Consulting Group, Inc.
T: 301-670-4990