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News Release
A study funded by the NIH created the most comprehensive atlas of the human kidney to advance progress in understanding and treating kidney disease. The Kidney Tissue Atlas marks an important milestone for the multicenter study, called the Kidney Precision Medicine Project (KPMP), which began in 2017 with the aim of improving treatment for kidney disease.
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News Release
A study supported by the National Institutes of Health found that people who experienced acute kidney injury (AKI) during a hospitalization, including those admitted with AKI or who developed AKI in the hospital, were more likely to revisit the hospital or die shortly after discharge, compared to people hospitalized without AKI. AKI is a sudden loss of kidney function that usually lasts for a short time. The research, funded by NIH’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), was published in the American Journal of Kidney Diseases.
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News Release
Artificial pancreas technology improved blood glucose control in young children between ages 2 and 6 with type 1 diabetes, according to the results of the Pediatric Artificial Pancreas (PEDAP) Trial, a 13-week randomized controlled trial conducted at three pediatric diabetes centers across the United States.
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News Release
Findings from NIH-supported clinical trial showed early treatment of diabetes slows progression to severe disease, but it did not improve visual acuity compared with treating more severe disease once it developed.
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News Release
A research team supported by the National Institutes of Health has developed a new approach to better understand the biology of polycystic kidney disease (PKD), and often-life-threatening genetic disorder that affects millions worldwide. Scientists combined two ways to model the disorder — organ-in-a-dish and organ-on-a-chip technologies — to show the role of glucose, a sugar commonly found in blood, in forming PKD cysts.
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Research Update
Listening in on how liver cells communicate amongst themselves led to discovery of new therapeutic targets for an advanced stage of nonalcoholic fatty liver disease.
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News Release
The number of young people under age 20 with diabetes in the United States is likely to increase more rapidly in future decades, according to a new modeling study published today in Diabetes Care.
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Research Update
Researchers have clarified what genetic variations can cause polycystic kidney disease in people.
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Research Update
Organ-on-a-chip technology has provided new insight into how glucose uptake affects cyst formation within the kidney.
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Research Update
A combination treatment regimen could increase long-term clearance of the hepatitis B virus.
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Research Update
Treating the rare genetic disorder Pompe disease in utero may halt prenatal organ damage and improve health after birth.
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News Release
Taking a personalized approach to kidney disease screening for people with type 1 diabetes (T1D) may reduce the time that chronic kidney disease (CKD) goes undetected, according to a new analysis performed by the Epidemiology of Diabetes Interventions and Complications study group, which is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The finding, published in Diabetes Care, provides the basis for the first evidence-based kidney screening model for people with T1D.
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Research Update
Improvements offer ways to simultaneously track the activity of multiple genes faster and more cheaply.
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Research Update
Mouse study revealed why eating late at night can be linked to weight gain and metabolic disease.
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Research Update
New research in mice points to a possible connection between nerves, intestinal mucus, and gastrointestinal inflammation.
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Research Update
Researchers have used new mini-livers or organoids to study fatty liver disease with or without type 2 diabetes.
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Research Update
New research in mice has identified a way that surgical and dietary weight-loss therapies lead to improvements in metabolic and digestive health.
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Research Update
New way to restart production of fetal hemoglobin suggests a potential therapy for some inherited blood disorders.
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Research Update
Customized behavioral weight loss programs can improve weight loss results and may help reduce diabetes risk more effectively than a one-size-fits-all approach.
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News Release
A device known as a bionic pancreas, which uses next-generation technology to automatically deliver insulin, was more effective at maintaining blood glucose (sugar) levels within normal range than standard-of-care management among people with type 1 diabetes, a new multicenter clinical trial has found.
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News Release
In a large clinical trial that directly compared four drugs commonly used to treat type 2 diabetes, researchers found that insulin glargine and liraglutide performed the best of four medications approved by the U.S. Food and Drug Administration to maintain blood glucose levels in the recommended range.
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Research Update
Researchers studied how two manifestations of overactive bladder are related, knowledge that could lead to more personalized treatment approaches.
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Research Update
Researchers have discovered sensory nerve cells that send messages from fat tissue to the brain in mice.
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Research Update
People have a lower chance of future kidney stone problems if smaller, asymptomatic kidney stones are also removed during surgery to remove larger, symptomatic ones.
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Research Update
Some people with H. pylori infections may be more likely to develop stomach cancer due to a genetic variation that causes a stronger response to the bacteria.
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Research Update
Those who lived in areas previously graded as less desirable had significantly worse health outcomes than those who did not, and these negative health impacts persisted for decades.
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News Release
NIH-funded clinical trial finds that starting with a cheaper drug and switching to a more expensive drug as needed leads to good vision outcomes in diabetic macular edema.
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Research Update
Certain human gut microbes can mine dietary fiber to extract a beneficial nutrient that otherwise would remain inaccessible to the human body.
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Research Update
Results of a study on NAFLD in children show that some genetic variants increase risk of disease, particularly its more severe form.
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Research Update
Researchers have produced a reference source that shows in detail how healthy adult human kidneys are organized at the cellular level.
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Research Update
Metformin and lifestyle changes reduce type 2 diabetes risk but may not provide additional protection against cardiovascular disease if other risk factors are well controlled.
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Research Update
New research has provided insight into a particularly distressing form of chronic diarrhea, setting the foundation for improved ways to diagnose and treat it.
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Research Update
Research in mice suggests a possible new approach for treating hemochromatosis, a disease in which blood iron levels are too high.
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Research Update
LiverTox is a web-based resource for information on drug-induced liver injury from prescription and OTC drugs, and complementary and alternative medicines.
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Research Update
Scientists have discovered how certain bacteria might suppress gastrointestinal inflammation by modifying a bile acid in the gut.
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Research Update
Research in mice brings new understanding of weight gain caused by some type 2 diabetes drugs, which could lead to diabetes treatments with fewer side effects.
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Research Update
A small clinical trial has highlighted a new possible oral therapy to delay type 1 diabetes progression and a possible new biological marker to monitor the disease.
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Research Update
Previously identified groups of genetic variations that increase the risk of type 2 diabetes may also influence the risk of developing other metabolic conditions.
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Research Update
Two recent studies explored new potential approaches for treating prostate enlargement.
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Research Update
Two recent findings shed new light on how the immune system can affect kidney health.
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Research Update
The NIDDK is committed to overcoming the dearth of minority scientists across its mission areas.
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Research Update
For many decades, the NIDDK and the NIH have supported foundational research to better understand the metabolic dysfunction underlying primary hyperoxaluria type 1.
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News Release
The National Institutes of Health is awarding $170 million over five years, pending the availability of funds, to clinics and centers across the country for a new study that will develop algorithms to predict individual responses to food and dietary routines.
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News Release
The National Institutes of Health has launched the first phase of the Neuromod Prize, a $9.8 million competition to accelerate the development of neuromodulation therapies — targeted treatments that adjust nerve activity to improve organ function.
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Research Update
Diabetic foot ulcers may be preventable through early and intensive control of blood glucose levels in people with type 1 diabetes.
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Research Update
Researchers have discovered how gut sensory cells discern nutritive sugars from non-caloric artificial sweeteners to guide an animal’s preferences.
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Research Update
Researchers identified a protein’s possible role in promoting intestinal healing in people with inflammatory bowel disease.
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Research Update
By studying differences between diabetic foot ulcers that heal and those that do not, researchers discovered a subset of cells that promote successful wound healing.
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Research Update
Scientists recently used a new strategy to identify, screen, and test possible new drugs to treat hyperparathyroidism by targeting the parathyroid hormone type 1 receptor protein.
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Research Update
Researchers have identified one way that cells determine which microRNAs to release to affect other cells—an insight that has implications for treating diseases associated with microRNA dysfunction.
