Targeting Fibrosis in Kidney, Bone Marrow, and Urological Diseases

Event Details

Meeting Objectives

Discuss Means of Detecting and Measuring Pathologic Fibrosis in Humans

Questions to be answered

Can we differentiate between pathologic fibrosis and that of normal aging?

Does fibrosis correlate with organ dysfunction?

Does imaging of fibrosis correlate with organ dysfunction, recovery, and regression?

What novel biomarkers or technologies should be pursued to detect and measure pathologic fibrosis?

Steering Committee

NIDDK Members

Tamara Bavendam, Terry Bishop, Ed Doo, Deborah Hoshizaki, Chris Ketchum, Ziya Kirkali, Maren Laughlin, Tracy Rankin, and Krystyna Rys-Sikora

NIBIB Member

Christina Liu

Agenda

October 31, 2013

7:30 a.m.

Registration

8:30 a.m.

Opening Remarks and Objectives
Dr. Robert Star and Dr. Michael Flessner

State-of-the-Art Lectures

(20 min. each followed by 10 min. discussion)

Moderator: TBD

8:45 a.m.

Mechanisms of Fibrosis
Dr. Thomas Wynn

JAK2 Story in Myelofibrosis
Dr. Kenneth Kaushansky

Advances in Liver Fibrosis Research
Dr. Scott Friedman

10:15 a.m.

Break

Detection (Imaging) of Pathologic Fibrosis

(20 min. + 10 min. for questions)

Moderator: TBD

10:45 a.m.

Molecular Imaging
Dr. Bryan Fuchs

Imaging Kidney Fibrosis With Labeled Macrophages
Dr. Rafael Kramann

Fibrosis and Prostate Disease
Dr. Chad Vezina

12:15 p.m.

Lunch (on your own)

Pathologic Fibrosis and Organ Dysfunction

(20 min. + 10 min. for questions)

Moderator: TBD

1:15 p.m.

Urinary Obstruction and Fibrosis
Dr. Jill Macoska

Myofibroblasts and Kidney Fibrosis
Dr. Raghu Kalluri

Hematologic Fibrosis: Monitoring Dysfunction and Recovery
Dr. Joachim Deeg

2:45 p.m.

Break

3:15 p.m.

Breakout Sessions:

1. Differentiation of Pathologic Fibrosis From That of “Normal Aging”
2. Organ Dysfunction: Does it Correlate With Degree of Fibrosis?
3. Can Imaging Detect and Measure Fibrosis?
4. Novel Biomarkers or Technology for Detection of Fibrosis

5:00 p.m.

Preliminary Reports From the Breakout Sessions and General Discussion

6:00 p.m.

Adjourn for the day

November 1, 2013

7:00 – 8:00 a.m.

Registration

FDA Procedures for Qualification

(20 min. each + 10 min. for questions)

Moderator: TBD

8:00 – 9:30 a.m.

Biomarker Qualification
FDA Speaker

Device Qualification
FDA Speaker

Molecular Probe Qualification
Dr. Libero (Louis) Marzella (invited)

9:30 a.m.

Break

9:45 a.m.

Breakouts Reconvene

11:15 a.m.

Final Breakout Reports

12:15 p.m.

Summary
Dr. Robert Star and Dr. Michael Flessner

1:00 p.m.

Adjournment