Two-thirds of the genome is transcribed into RNA, yet less than 2 percent is translated into protein. What is all that noncoding RNA doing? Recent findings suggest possible regulatory roles for noncoding RNA. The purpose of this workshop is to explore the latest research implicating noncoding RNAs as a functional component of hematopoiesis. Gaps in knowledge that would either support or refute this notion will be identified to help define opportunities, directions, and approaches for future research.
August 30, 2013
- 7:30 a.m.
- Registration and Poster Set-up
- 8:00 a.m.
- Welcoming and Opening Remarks
Terry Bishop, Ph.D.; Robert Star, M.D.—National Institute of Diabetes and Digestive and Kidney Diseas
- 8:15 a.m.
- Studying a LNC From Beginning to End
Jeannie T. Lee, Professor, Massachusetts General Hospital
Session 1: Definition: Finding and Recognizing Noncoding RNA
- 8:40 a.m.
- Definition of Coding vs. Noncoding DNA
John Stamatoyannopoulos, University of Washington
- 9:05 a.m.
- Structure and Function of Non-protein Coding RNA
Thomas Gingeras, Cold Spring Harbor Laboratory
- 9:30 a.m.
- LNC RNA Regulation of mRNA Stability
Lynne Maquat, University of Rochester
- 9:55 a.m.
- Break and Poster Set-up
- 10:20 a.m.
- Noncoding RNA in Enhancers
Doug Higgs, Oxford University
Session 2: Role of ncRNA in Differentiation and Development
- 10:45 a.m.
- Long Noncoding RNA in Hematopoiesis
Mitch Weiss, Children’s Hospital of Pennsylvania
- 11:10 a.m.
- Multiple Types of Long ncRNAs Regulate Red Blood Cell Development
Harvey Lodish, Massachusetts Institute of Technology
- 11:35 a.m.
- LncRNAs Control Hematopoietic Stem Cells (HSC) Function
Poster Presenter: Min Luo, Baylor College of Medicine
- 11:50 a.m.
- Lunch and Poster Viewing
- 1:30 p.m.
- HOTAIRM1 Regulates Cell Cycle
Poster Presenter: Xueqing Zhang, University of Massachusetts, Worcester
- 1:45 p.m.
- Intron Retention and Its Role in Granulopoiesis
Justin Wong, University of Sydney
- 2:10 p.m.
- Composition of the ncRNA “Milieu”
Pandolfi, Pier Paolo, Beth Israel Deaconess Medical Center
- 2:35 p.m.
Session 3: Update on miRNA in Myeloid Differentiation
- 2:45 p.m.
- The Role of Erythrocyte microRNAs in Sickle Cell Disease
Jen-Tsan Ashley Chi, Duke University
- 3:10 p.m.
- Deregulation of microRNAs in Myelodysplastic Syndrome
Daniel Starczynowski, Cincinnati Children’s Hospital
- 3:35 p.m.
- Summary of Workshop and Next Steps
- 5:00 p.m.