Pediatric Acute Liver Failure of Undetermined Cause: A Clinical Research Workshop

Event Details

Event Details

A one day research workshop bringing together clinical and translational investigators to define the clinical and pathophysiological aspects that characterize acute pediatric acute liver failure due to an undefined cause, currently labeled as indeterminate etiology.

Organizing Committee: Estella Alonso (LURIE), Simon Horslen (Seattle CH), Edward Behernsn (CHOP), Averell Sherker (NIDDK), Edward Doo (NIDDK), Jay Hoofnagle (NIDDK)

Agenda

October 16, 2015

8:15 a.m. - 8:30 a.m.

Welcome and Introduction
Estella Alonso and Edward Doo

Session 1: Clinical and Pathophysiological Features of PALF of Undetermined Cause

Moderator: Simon Horslen

8:30 a.m. - 8:50 a.m.

ALF of undetermined cause in children
Estella Alonso

8:50 a.m. - 9:10 a.m.

ALF of undetermined in adults
Todd Stravitz

9:10 a.m. - 9:30 a.m.

Pathology of Acute Liver Failure
David Kleiner

9:30 a.m. - 9:50 a.m.

Inflammatory Milieu in PALF
Ed Behrens

9:50 a.m. - 10:10 a.m.

Discussion

10:10 a.m. - 10:30 a.m.

Break

Session 2: Pathophysiological Mechanisms and Regeneration in Acute Liver Failure

Moderator: Ed Behrens

10:30 a.m. - 10:50 a.m.

Mechanisms of Immune Mediated Liver Injury
Harmut Jaeschke

10:50 a.m. - 11:10 a.m.

Modeling of Inflammatory Cascades in PALF
Yoram Vodovotz

11:10 a.m. - 11:30 a.m.

Growth Factors in Hepatic Regeneration
David Rudnick

11:30 a.m. - 11:50 a.m.

The Endothelial Cell in Hepatic Regeneration
Laurie DeLeve

11:50 a.m. - 12:10 p.m.

Discussion

12:10 p.m. - 1:20 p.m.

Lunch (on your own)

Session 3: Elucidation of Etiologies of PALF of Undetermined Cause

Moderator: David Rudnick

1:20 p.m. - 1:40 p.m.

Viral etiology discovery for PALF of undetermined cause
Charles Chiu

1:40 p.m. - 2:00 p.m.

Genomic approaches for the discovery of genetic variations that may be associated with PALF of undetermined cause
Mark Yandell

2:00 p.m. - 2:20 p.m.

Discussion

2:20 p.m. - 2:40 p.m.

Break

Session 4: Potential Therapeutic Targets and Approaches for PALF of Undetermined Cause

Moderator: Kathleen Loomes

2:40 p.m. - 3:00 p.m.

Drug Therapeutic Targets for Cytokine Storm, MAS and HLH
Alexei Grom

3:00 p.m. - 3:20 p.m.

Ongoing Treatment Trials and New Strategies
Simon Horlsen

3:20 p.m. - 3:40 p.m.

Treating Neuroinflammation
Mark Wainwright

3:40 p.m. - 4:00 p.m.

Discussion

4:00 p.m. - 4:15 p.m.

Break

Session 5: Defining research challenges, priorities, and opportunities for PALF of Undetermined Cause

Moderators: Alonso, Horslen, Beherns

4:15 p.m. - 5:00 p.m.

Defining research challenges, priorities, and opportunities for Indeterminate PALF
Audience and Moderators