Scientific observations support the hypothesis that macrophages regulate critical stages of the development, terminal differentiation, and death (or recycling) of erythrocytes. However the molecular interactions that occur between erythroid progenitors or erythrocytes and macrophages—and the biochemical pathways that govern those interactions—are incompletely understood. This workshop aims to review the most recent progress in the field and to promote discussion of the gaps in our knowledge of these biological processes and pathways. We also hope to gain a specific understanding of the current scientific and technologic barriers to the hematology research community in the pursuit of knowledge in this area.
February 20, 2016
- 8:00 a.m. – 8:30 a.m.
- 8:30 a.m. – 8:45 a.m.
- Welcome, Introduction, and Purpose
Terry Bishop, Ph.D. NIDDK, NIH
- 8:45 a.m. – 9:00 a.m.
- Perspective on Macrophages in Erythropoiesis: History and Horizons
Mohandas Narla, D.Sc. New York Blood Center
Session I: Developmental Origins of Macrophages
Moderator: Terry Bishop
- 9:00 a.m. – 9:20 a.m.
- Emergence of HSC-independent Myeloid and Erythroid Potential in the Mammalian Embryo
James Palis, M.D. University of Rochester
- 9:20 a.m. – 9:30 a.m.
- 9:30 a.m. – 9:50 a.m.
- Macrophage Lineages: Yolk Sac Versus Hematopoietic Stem Cells
Frederic Geissmann, M.D., Ph.D. King's College London
- 9:50 a.m. – 10:00 a.m.
- 10:00 a.m. – 10:20 a.m.
- Regulation of Tissue Macrophage Development and Function
Miriam Merad, M.D., Ph.D. Mt. Sinai School of Medicine
- 10:20 a.m. – 10:30 a.m.
- 10:30 a.m. – 11:00 a.m.
Session II: Macrophage-associated Erythropoiesis
Moderator: Manjit Hanspal
- 11:00 a.m. – 11:20 a.m.
- Role of KLF1 in Erythroid-myeloid Progenitors
James Bieker, Ph.D. Mt. Sinai School of Medicine
- 11:20 a.m. – 11:30 a.m.
- 11:30 a.m. – 11:50 a.m.
- Controlling Monocyte Fates
Beverly Torok-Storb, Ph.D. Fred Hutchison Cancer Research Center
- 11:50 a.m. – 12:00 p.m.
- 12:00 p.m. – 12:30 p.m.
- 12:30 p.m. – 1:30 p.m.
- Poster Session
Session III: Physical and Chemical Cell-Cell Interactions
Moderator: James Palis
- 1:30 p.m. – 1:50 p.m.
- Primitive Macrophages Regulate Definitive Blood Stem Cell Migration during Zebrafish Development
Elliott Hagedorn, Ph.D. Boston Children's Hospital
- 1:50 p.m. – 2:00 p.m.
- 2:00 p.m. – 2:20 p.m.
- Bone Marrow Cell-Cell Communication Regulates Blood Forming Stem Cell Development: The Role of aSMA+ Macrophages and Coagulation
Tsvee Lapidot, Ph.D. Weizmann Institute
- 2:20 p.m. – 2:30 p.m.
- 2:30 p.m. – 2:50 p.m.
- Environmental Influences on Macrophage Transcriptional Program
David Gosselin, Ph.D. University of California, San Diego
- 2:50 p.m. – 3:00 p.m.
- 3:00 p.m. – 3:15 p.m.
Session IV: Role of Macrophages in Erythroid Survival and Turnover
Moderator: Cindy Roy
- 3:15 p.m. – 3:35 p.m.
- Dissecting the Functional Contribution of Erythroid Cells and Macrophage Subsets to Erythroid Stress Response
Thalia Papayannopoulou, M.D., D.Sc. University of Washington
- 3:35 p.m. – 3:45 p.m.
- 3:45 p.m. – 4:05 p.m.
- Changes in Macrophage Signals Regulate Stress Erythropoiesis
Robert Paulson, Ph.D. Pennsylvania State University
- 4:05 p.m. – 4:15 p.m.
Session V: Needs Assessment and Unanswered Questions
Moderator: Nohandas Narla
- 4:15 p.m. – 5:00 p.m.
- Open Forum
Recorders: Terry Bishop, Ph.D.
Manjit Hanspal, Ph.D.
Cindy Roy, Ph.D. NIDDK/NHLBI, NIH
- 5:00 p.m.