Precision Medicine in Pancreatic Disease: Knowledge Gaps and Research Opportunities

Event Details

Objectives

The purpose of this workshop is to understand the current status of methods and applications of Precision Medicine as they apply to the diagnosis and management of pancreatic disease, and to explore how to translate precision medicine findings to create strategies for personalized approaches for the prevention, early diagnosis, and treatment options for patients with benign and malignant pancreatic disease. The knowledge gaps, barriers and priorities for conducting basic and clinical studies to advance the field will be identified.

Organizing Committee

Dana K. Andersen, M.D. DDDN/NIDDK/NIH
Darwin Conwell, M.D. Division of Gastroenterology, Ohio State University
Christopher E. Forsmark, M.D. Division of Gastroenterology, University of Florida
Fred Gorelick, M.D. Division of Gastroenterology, Yale University
Aida Habtezion, M.D., M.Sc. Division of Gastroenterology, Stanford University
Mark E. Lowe, M.D., Ph.D. Dept of Pediatrics, Washington University at St. Louis
Stephen J. Pandol, M.D. Division of Gastroenterology, Cedars Sinai Medical Center
Ashok K. Saluja, Ph.D. Dept of Surgery, University of Miami
Jose Serrano, M.D., Ph.D. DDDN/NIDDK/NIH
Vikesh K. Singh, M.D., M.Sc. Division of Gastroenterology, Johns Hopkins University
Hanno Steen, Ph.D. Dept of Pathology, Boston Children’s Hospital
Temel Tirkes, M.D. Dept of Radiology, Indiana University
Mark D. Topazian, M.D. Division of Gastroenterology, Mayo Clinic
Aliye Uc, M.D. Dept of Pediatrics, University of Iowa
Aynur Unalp-Arida, M.D., Ph.D. DDDN/NIDDK/NIH
David C. Whitcomb, M.D., Ph.D. Division of Gastroenterology, University of Pittsburgh

Registration Deadline

Agenda

July 24, 2019

7:30 a.m. – 8:00 a.m.

Registration

8:00 a.m. – 8:15 a.m.

Welcome and Introduction
Aida Habtezion, M.D., M.Sc., Stanford University and Mark Lowe, M.D., Ph.D., Washington University School of Medicine in St. Louis

8:15 a.m. – 8:45 a.m.

Overview Lecture
Joe Gray, Ph.D., Knight Cancer Institute, Oregon Health & Science University

Session One: General Considerations

8:45 a.m. – 9:05 a.m.

Case Presentation—Hereditary Pancreatitis and the Risk of Complications
Mark Lowe, M.D., Ph.D., Washington University School of Medicine in St. Louis

9:05 a.m.– 9:30 a.m.

Bioinformatics Approaches to Precision Diagnosis
Joshua Swamidass, Ph.D., Washington University School of Medicine in St. Louis

9:30 a.m.– 9:55 a.m.

The Application of Artificial Intelligence and Deep Learning in Pancreatic Imaging
Holger Roth, Ph.D., M.Sc., Nvidia Corporation

9:55 a.m. – 10:15 a.m.

Break

Session Two: -Omics: The Combination of Risk Factors and Biomarkers

10:15 a.m. – 10:40 a.m.

Proteomics—A Tool for Cancer Therapeutics
Jyoti Choudhary, Ph.D., Institute for Cancer Research, University of London

10:40 a.m. – 11:05 a.m.

Genomics—A Tool for Therapeutics Development in Benign Pancreatic Disease
Mark Haupt, M.D., Ariel Medicine

11:05 a.m. – 11:30 a.m.

Metabolomics Applications in Benign and Malignant Disease
Sylvia Plevritis, Ph.D., Stanford University

11:30 a.m. – 12:00 p.m.

Multiplex Explorations of Inflammation in Cancer and Pancreatitis
Aida Habtezion, M.D., M.Sc., Stanford University

12:00 p.m. – 1:00 p.m.

Lunch

Session Three: Precision Imaging—From Macro to Micro

1:00 p.m. – 1:25 p.m.

Quantitative Imaging of Chronic Pancreatitis
Temel Tirkes, M.D., Indiana University School of Medicine

1:25 p.m. – 1:50 p.m.

Advances in Molecular Imaging
Kimberly Kelly, Ph.D., University of Virginia

1:50 p.m. – 2:15 p.m.

Imaging Mass Spectrometry for Benign Disease
Richard Caprioli, Ph.D., Vanderbilt University

2:15 p.m. – 2:40 p.m.

Image Mass Spectrometry for Malignancy
Kirill Veselkov, Ph.D., M.Sc., Imperial College London

2:40 p.m. – 3:00 p.m.

Discussion and Q&A

3:00 p.m. – 3:15 p.m.

Break

Session Four: Gaps, Barriers, Needs, and How to Get from Precision Medicine to Personalized Medicine for Pancreatic Disease

3:15 p.m. – 3:40 p.m.

Transforming Precision Medicine to Personalized Medicine
Kenneth Olive, Ph.D., Columbia University

3:40 p.m. – 4:05 p.m.

Unmet Needs of Precision Medicine
Noa Rappaport, Ph.D., Institute for Systems Biology

4:05 p.m. – 4:30 p.m.

Barriers and Research Priorities
David Whitcomb, M.D., Ph.D., University of Pittsburgh

4:30 p.m. – 5:00 p.m.

Panel Discussion and Q&A

5:00 p.m.

Adjournment