Sunita K. Agarwal, Ph.D.

Staff Scientist: Signal Transduction Section, Metabolic Diseases Branch

Scientific Focus Areas: Cancer Biology, Cell Biology, Chromosome Biology, Genetics and Genomics, Molecular Biology and Biochemistry

sunitaa@amb.niddk.nih.gov 301-402-7834 Add to Contacts

Publications

A selection of recent and significant publications can be viewed below.

Blood-based Proteomic Signatures Associated With MEN1-related Duodenopancreatic Neuroendocrine Tumor Progression.

Fahrmann JF, Wasylishen AR, Pieterman CRC, Irajizad E, Vykoukal J, Wu R, Dennison JB, Peterson CB, Zhao H, Do KA, Halperin DM, Agarwal SK, Blau JE, Jha S, Rivero JD, Nilubol N, Walter MF, Welch JM, Weinstein LS, Vriens MR, van Leeuwaarde RS, van Treijen MJC, Valk GD, Perrier ND, Hanash SM, Katayama H.

J Clin Endocrinol Metab (2023 Nov 17) 108:3260-3271. Abstract/Full Text

A Knock-In Mouse Model of the Gcm2 Variant p.Y392S Develops Normal Parathyroid Glands.

Parekh VI, Brinster LR, Guan B, Simonds WF, Weinstein LS, Agarwal SK.

J Endocr Soc (2023 Oct 9) 7:bvad126. Abstract/Full Text

Germline- and Somatic-Inactivating FLCN Variants in Parathyroid Cancer and Atypical Parathyroid Tumors.

Jha S, Welch J, Tora R, Lack J, Warner A, Del Rivero J, Sadowski SM, Nilubol N, Schmidt LS, Linehan WM, Weinstein LS, Simonds WF, Agarwal SK.

J Clin Endocrinol Metab (2023 Sep 18) 108:2686-2698. Abstract/Full Text

Mice With RIP-Cre-mediated Deletion of the Long Noncoding RNA Meg3 Show Normal Pancreatic Islets and Enlarged Pituitary.

Parekh VI, Sun H, Chen M, Weinstein LS, Agarwal SK.

J Endocr Soc (2022 Oct 11) 6:bvac141. Abstract/Full Text

Novel GLCCI1-BRAF fusion drives kinase signaling in a case of pheochromocytomatosis.

Green BL, Grant RRC, Richie CT, Chatterjee B, Sampaio De Melo M, Barr FG, Pacak K, Agarwal SK, Nilubol N.

Eur J Endocrinol (2022 Jul 1) 187:185-196. Abstract/Full Text

A Blood-based Polyamine Signature Associated With MEN1 Duodenopancreatic Neuroendocrine Tumor Progression.

Fahrmann JF, Wasylishen AR, Pieterman CRC, Irajizad E, Vykoukal J, Murage E, Wu R, Dennison JB, Krishna H, Peterson CB, Lozano G, Zhao H, Do KA, Halperin DM, Agarwal SK, Blau JE, Del Rivero J, Nilubol N, Walter MF, Welch JM, Weinstein LS, Vriens MR, van Leeuwaarde RS, van Treijen MJC, Valk GD, Perrier ND, Hanash SM.

J Clin Endocrinol Metab (2021 Nov 19) 106:e4969-e4980. Abstract/Full Text

Parathyroid Hormone Resistance and Autoantibodies to the PTH1 Receptor.

Mandl A, Burbelo PD, Di Pasquale G, Tay YS, Welch J, Lionakis MS, Rosenzweig SD, Waldman MA, Warner BM, Walitt B, Collins MT, Balow JE, Chiorini JA, Simonds WF, Agarwal SK, Blau JE, Weinstein LS.

N Engl J Med (2021 Nov 18) 385:1974-1980. Abstract/Full Text

Two distinct classes of thymic tumors in patients with MEN1 show LOH at the MEN1 locus.

Mandl A, Welch JM, Kapoor G, Parekh VI, Schrump DS, Ripley RT, Walter MF, Del Rivero J, Jha S, Simonds WF, Jensen RT, Weinstein LS, Blau JE, Agarwal SK.

Endocr Relat Cancer (2021 Oct 4) 28:L15-L19. Abstract/Full Text

Multiple Endocrine Neoplasia Type 1: Latest Insights.

Brandi ML, Agarwal SK, Perrier ND, Lines KE, Valk GD, Thakker RV.

Endocr Rev (2021 Mar 15) 42:133-170. Abstract/Full Text

Molecular Signatures and Their Clinical Utility in Pancreatic Neuroendocrine Tumors.

Chatani PD, Agarwal SK, Sadowski SM.

Front Endocrinol (Lausanne) (2020) 11:575620. Abstract/Full Text

Distinct DNA Methylation Signatures in Neuroendocrine Tumors Specific for Primary Site and Inherited Predisposition.

Tirosh A, Killian JK, Petersen D, Zhu YJ, Walker RL, Blau JE, Nilubol N, Patel D, Agarwal SK, Weinstein LS, Meltzer P, Kebebew E.

J Clin Endocrinol Metab (2020 Oct 1) 105:3285-94. Abstract/Full Text

c-MET inhibition: novel treatment for sporadic and MEN1-associated GEP NETs.

Lee ME, Tepede AA, Mandl A, Weinstein LS, Del Rivero J, Agarwal SK, Blau JE.

J Mol Endocrinol (2020 Aug) 65:R1-R17. Abstract/Full Text

Clinical presentation and management of primary ovarian neuroendocrine tumor in multiple endocrine neoplasia type 1.

Jhawar S, Lakhotia R, Suzuki M, Welch J, Agarwal SK, Sharretts J, Merino M, Ahlman M, Blau JE, Simonds WF, Del Rivero J.

Endocrinol Diabetes Metab Case Rep (2019 Aug 20) 2019. Abstract/Full Text

Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo.

Thakur S, Daley B, Gaskins K, Vasko VV, Boufraqech M, Patel D, Sourbier C, Reece J, Cheng SY, Kebebew E, Agarwal S, Klubo-Gwiezdzinska J.

Clin Cancer Res (2018 Aug 15) 24:4030-4043. Abstract/Full Text

Epigenetic regulation in the tumorigenesis of MEN1-associated endocrine cell types.

Iyer S, Agarwal SK.

J Mol Endocrinol (2018 Jul) 61:R13-R24. Abstract/Full Text

Probability of Positive Genetic Testing Results in Patients with Family History of Primary Hyperparathyroidism.

El Lakis M, Nockel P, Gaitanidis A, Guan B, Agarwal S, Welch J, Simonds WF, Weinstein L, Marx S, Nilubol N, Patel D, Merkel R, Tirosh A, Kebebew E.

J Am Coll Surg (2018 May) 226:933-938. Abstract/Full Text

Frequency and consequence of the recurrent YY1 p.T372R mutation in sporadic insulinomas.

Parekh VI, Modali SD, Welch J, Simonds WF, Weinstein LS, Kebebew E, Agarwal SK.

Endocr Relat Cancer (2018 May) 25:L31-L35. Abstract/Full Text

Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype.

Keutgen XM, Kumar S, Gara SK, Boufraqech M, Agarwal S, Hruban RH, Nilubol N, Quezado M, Finney R, Cam M, Kebebew E.

Cancer (2018 Feb 1) 124:636-647. Abstract/Full Text

Functional Defects From Endocrine Disease-Associated Mutations in HLXB9 and Its Interacting Partner, NONO.

Kharade SS, Parekh VI, Agarwal SK.

Endocrinology (2018 Feb 1) 159:1199-1212. Abstract/Full Text

Familial isolated primary hyperparathyroidism associated with germline GCM2 mutations is more aggressive and has a lesser rate of biochemical cure.

El Lakis M, Nockel P, Guan B, Agarwal S, Welch J, Simonds WF, Marx S, Li Y, Nilubol N, Patel D, Yang L, Merkel R, Kebebew E.

Surgery (2018 Jan) 163:31-34. Abstract/Full Text

Long Noncoding RNA MEG3 Is an Epigenetic Determinant of Oncogenic Signaling in Functional Pancreatic Neuroendocrine Tumor Cells.

Iyer S, Modali SD, Agarwal SK.

Mol Cell Biol (2017 Nov 15) 37. Abstract/Full Text

The future: genetics advances in MEN1 therapeutic approaches and management strategies.

Agarwal SK.

Endocr Relat Cancer (2017 Oct) 24:T119-T134. Abstract/Full Text

Ethnicity of Patients With Germline GCM2-Activating Variants and Primary Hyperparathyroidism.

Guan B, Welch JM, Vemulapalli M, Li Y, Ling H, Kebebew E, Simonds WF, Marx SJ, Agarwal SK.

J Endocr Soc (2017 May 1) 1:488-499. Abstract/Full Text

GCM2-Activating Mutations in Familial Isolated Hyperparathyroidism.

Guan B, Welch JM, Sapp JC, Ling H, Li Y, Johnston JJ, Kebebew E, Biesecker LG, Simonds WF, Marx SJ, Agarwal SK.

Am J Hum Genet (2016 Nov 3) 99:1034-1044. Abstract/Full Text

Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b).

Desai SS, Kharade SS, Parekh VI, Iyer S, Agarwal SK.

J Biol Chem (2015 Oct 16) 290:25595-608. Abstract/Full Text

Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer.

Gara SK, Jia L, Merino MJ, Agarwal SK, Zhang L, Cam M, Patel D, Kebebew E.

N Engl J Med (2015 Jul 30) 373:448-55. Abstract/Full Text

Epigenetic regulation of the lncRNA MEG3 and its target c-MET in pancreatic neuroendocrine tumors.

Modali SD, Parekh VI, Kebebew E, Agarwal SK.

Mol Endocrinol (2015 Feb) 29:224-37. Abstract/Full Text

Consequence of Menin Deficiency in Mouse Adipocytes Derived by In Vitro Differentiation.

Parekh VI, Modali SD, Desai SS, Agarwal SK.

Int J Endocrinol (2015) 2015:149826. Abstract/Full Text

GSK-3β protein phosphorylates and stabilizes HLXB9 protein in insulinoma cells to form a targetable mechanism of controlling insulinoma cell proliferation.

Desai SS, Modali SD, Parekh VI, Kebebew E, Agarwal SK.

J Biol Chem (2014 Feb 28) 289:5386-98. Abstract/Full Text

Exploring the tumors of multiple endocrine neoplasia type 1 in mouse models for basic and preclinical studies.

Agarwal SK.

Int J Endocr Oncol (2014) 1:153-161. Abstract/Full Text

Germline and somatic mutations in cyclin-dependent kinase inhibitor genes CDKN1A, CDKN2B, and CDKN2C in sporadic parathyroid adenomas.

Costa-Guda J, Soong CP, Parekh VI, Agarwal SK, Arnold A.

Horm Cancer (2013 Oct) 4:301-7. Abstract/Full Text

The embryonic transcription factor Hlxb9 is a menin interacting partner that controls pancreatic β-cell proliferation and the expression of insulin regulators.

Shi K, Parekh VI, Roy S, Desai SS, Agarwal SK.

Endocr Relat Cancer (2013 Feb) 20:111-22. Abstract/Full Text

Multiple endocrine neoplasia type 1.

Agarwal SK.

Front Horm Res (2013) 41:1-15. Abstract/Full Text

Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors.

Agarwal SK, Jothi R.

PLoS One (2012) 7:e37952. Abstract/Full Text

The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization.

Wang Y, Ozawa A, Zaman S, Prasad NB, Chandrasekharappa SC, Agarwal SK, Marx SJ.

Cancer Res (2011 Jan 15) 71:371-82. Abstract/Full Text

Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states.

Agarwal SK, Mateo CM, Marx SJ.

J Clin Endocrinol Metab (2009 May) 94:1826-34. Abstract/Full Text

The MEN1 gene and pituitary tumours.

Agarwal SK, Ozawa A, Mateo CM, Marx SJ.

Horm Res (2009 Apr) 71 Suppl 2:131-8. Abstract/Full Text

The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3.

Agarwal SK, Simonds WF, Marx SJ.

Mol Cancer (2008 Aug 7) 7:65. Abstract/Full Text

Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation.

Agarwal SK, Impey S, McWeeney S, Scacheri PC, Collins FS, Goodman RH, Spiegel AM, Marx SJ.

Neoplasia (2007 Feb) 9:101-7. Abstract/Full Text

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.

Scacheri PC, Davis S, Odom DT, Crawford GE, Perkins S, Halawi MJ, Agarwal SK, Marx SJ, Spiegel AM, Meltzer PS, Collins FS.

PLoS Genet (2006 Apr) 2:e51. Abstract/Full Text

Menin molecular interactions: insights into normal functions and tumorigenesis.

Agarwal SK, Kennedy PA, Scacheri PC, Novotny EA, Hickman AB, Cerrato A, Rice TS, Moore JB, Rao S, Ji Y, Mateo C, Libutti SK, Oliver B, Chandrasekharappa SC, Burns AL, Collins FS, Spiegel AM, Marx SJ.

Horm Metab Res (2005 Jun) 37:369-74. Abstract/Full Text

Molecular pathology of the MEN1 gene.

Agarwal SK, Lee Burns A, Sukhodolets KE, Kennedy PA, Obungu VH, Hickman AB, Mullendore ME, Whitten I, Skarulis MC, Simonds WF, Mateo C, Crabtree JS, Scacheri PC, Ji Y, Novotny EA, Garrett-Beal L, Ward JM, Libutti SK, Richard Alexander H, Cerrato A, Parisi MJ, Santa Anna-A S, Oliver B, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ.

Ann N Y Acad Sci (2004 Apr) 1014:189-98. Abstract/Full Text

Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter.

Agarwal SK, Novotny EA, Crabtree JS, Weitzman JB, Yaniv M, Burns AL, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ.

Proc Natl Acad Sci U S A (2003 Sep 16) 100:10770-5. Abstract/Full Text

HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome.

Carpten JD, Robbins CM, Villablanca A, Forsberg L, Presciuttini S, Bailey-Wilson J, Simonds WF, Gillanders EM, Kennedy AM, Chen JD, Agarwal SK, Sood R, Jones MP, Moses TY, Haven C, Petillo D, Leotlela PD, Harding B, Cameron D, Pannett AA, Höög A, Heath H 3rd, James-Newton LA, Robinson B, Zarbo RJ, Cavaco BM, Wassif W, Perrier ND, Rosen IB, Kristoffersson U, Turnpenny PD, Farnebo LO, Besser GM, Jackson CE, Morreau H, Trent JM, Thakker RV, Marx SJ, Teh BT, Larsson C, Hobbs MR.

Nat Genet (2002 Dec) 32:676-80. Abstract/Full Text

Identification and characterization of JunD missense mutants that lack menin binding.

Knapp JI, Heppner C, Hickman AB, Burns AL, Chandrasekharappa SC, Collins FS, Marx SJ, Spiegel AM, Agarwal SK.

Oncogene (2000 Sep 28) 19:4706-12. Abstract/Full Text

Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.

Agarwal SK, Guru SC, Heppner C, Erdos MR, Collins RM, Park SY, Saggar S, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ, Burns AL.

Cell (1999 Jan 8) 96:143-52. Abstract/Full Text

Comparative genomic hybridization analysis of human parathyroid tumors.

Agarwal SK, Schröck E, Kester MB, Burns AL, Heffess CS, Ried T, Marx SJ.

Cancer Genet Cytogenet (1998 Oct 1) 106:30-6. Abstract/Full Text

Somatic mutation of the MEN1 gene in parathyroid tumours.

Heppner C, Kester MB, Agarwal SK, Debelenko LV, Emmert-Buck MR, Guru SC, Manickam P, Olufemi SE, Skarulis MC, Doppman JL, Alexander RH, Kim YS, Saggar SK, Lubensky IA, Zhuang Z, Liotta LA, Chandrasekharappa SC, Collins FS, Spiegel AM, Burns AL, Marx SJ.

Nat Genet (1997 Aug) 16:375-8. Abstract/Full Text

Positional cloning of the gene for multiple endocrine neoplasia-type 1.

Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, Emmert-Buck MR, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Crabtree JS, Wang Y, Roe BA, Weisemann J, Boguski MS, Agarwal SK, Kester MB, Kim YS, Heppner C, Dong Q, Spiegel AM, Burns AL, Marx SJ.

Science (1997 Apr 18) 276:404-7. Abstract/Full Text

Dysfunctional growth hormone receptor in a strain of sex-linked dwarf chicken: evidence for a mutation in the intracellular domain.

Agarwal SK, Cogburn LA, Burnside J.

J Endocrinol (1994 Sep) 142:427-34. Abstract/Full Text