William A. Eaton, M.D., Ph.D., NIH Distinguished Investigator

Photo of William Eaton.
Scientific Focus Areas: Biomedical Engineering and Biophysics, Molecular Pharmacology

Publications

A selection of recent and significant publications can be viewed below.

Select Publications

Single-molecule fluorescence experiments determine protein folding transition path times.
Chung HS, McHale K, Louis JM, Eaton WA.
Science (2012 Feb 24) 335:981-4. Abstract/Full Text
Kinetic assay shows that increasing red cell volume could be a treatment for sickle cell disease.
Li Q, Henry ER, Hofrichter J, Smith JF, Cellmer T, Dunkelberger EB, Metaferia BB, Jones-Straehle S, Boutom S, Christoph GW, Wakefield TH, Link ME, Staton D, Vass ER, Miller JL, Hsieh MM, Tisdale JF, Eaton WA.
Proc Natl Acad Sci U S A (2017 Jan 31) 114:E689-E696. Abstract/Full Text
Universality of supersaturation in protein-fiber formation.
Cellmer T, Ferrone FA, Eaton WA.
Nat Struct Mol Biol (2016 May) 23:459-61. Abstract/Full Text
Native contacts determine protein folding mechanisms in atomistic simulations.
Best RB, Hummer G, Eaton WA.
Proc Natl Acad Sci U S A (2013 Oct 29) 110:17874-9. Abstract/Full Text
Treating sickle cell disease by targeting HbS polymerization.
Eaton WA, Bunn HF.
Blood (2017 May 18) 129:2719-2726. Abstract/Full Text

Additional Publications

Protein folding transition path times from single molecule FRET.
Chung HS, Eaton WA.
Curr Opin Struct Biol (2018 Feb) 48:30-39. Abstract/Full Text
Theory, simulations, and experiments show that proteins fold by multiple pathways.
Eaton WA, Wolynes PG.
Proc Natl Acad Sci U S A (2017 Nov 14) 114:E9759-E9760. Abstract/Full Text
Structural origin of slow diffusion in protein folding.
Chung HS, Piana-Agostinetti S, Shaw DE, Eaton WA.
Science (2015 Sep 25) 349:1504-10. Abstract/Full Text
Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models.
Henry ER, Mozzarelli A, Viappiani C, Abbruzzetti S, Bettati S, Ronda L, Bruno S, Eaton WA.
Biophys J (2015 Sep 15) 109:1264-72. Abstract/Full Text
Testing Landscape Theory for Biomolecular Processes with Single Molecule Fluorescence Spectroscopy.
Truex K, Chung HS, Louis JM, Eaton WA.
Phys Rev Lett (2015 Jul 3) 115:018101. Abstract/Full Text
Experimental basis for a new allosteric model for multisubunit proteins.
Viappiani C, Abbruzzetti S, Ronda L, Bettati S, Henry ER, Mozzarelli A, Eaton WA.
Proc Natl Acad Sci U S A (2014 Sep 2) 111:12758-63. Abstract/Full Text
Single-molecule fluorescence probes dynamics of barrier crossing.
Chung HS, Eaton WA.
Nature (2013 Oct 31) 502:685-8. Abstract/Full Text
Comparing a simple theoretical model for protein folding with all-atom molecular dynamics simulations.
Henry ER, Best RB, Eaton WA.
Proc Natl Acad Sci U S A (2013 Oct 29) 110:17880-5. Abstract/Full Text
Measuring ultrafast protein folding rates from photon-by-photon analysis of single molecule fluorescence trajectories.
Chung HS, Cellmer T, Louis JM, Eaton WA.
Chem Phys (2013 Aug 30) 422:229-237. Abstract/Full Text
Chemical physics of protein folding.
Wolynes PG, Eaton WA, Fersht AR.
Proc Natl Acad Sci U S A (2012 Oct 30) 109:17770-1. Abstract/Full Text
Solution structure of the ESCRT-I and -II supercomplex: implications for membrane budding and scission.
Boura E, Różycki B, Chung HS, Herrick DZ, Canagarajah B, Cafiso DS, Eaton WA, Hummer G, Hurley JH.
Structure (2012 May 9) 20:874-86. Abstract/Full Text
Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy.
Boura E, Rózycki B, Herrick DZ, Chung HS, Vecer J, Eaton WA, Cafiso DS, Hummer G, Hurley JH.
Proc Natl Acad Sci U S A (2011 Jun 7) 108:9437-42. Abstract/Full Text
Extracting rate coefficients from single-molecule photon trajectories and FRET efficiency histograms for a fast-folding protein.
Chung HS, Gopich IV, McHale K, Cellmer T, Louis JM, Eaton WA.
J Phys Chem A (2011 Apr 28) 115:3642-56. Abstract/Full Text
Making connections between ultrafast protein folding kinetics and molecular dynamics simulations.
Cellmer T, Buscaglia M, Henry ER, Hofrichter J, Eaton WA.
Proc Natl Acad Sci U S A (2011 Apr 12) 108:6103-8. Abstract/Full Text
Distinguishing between protein dynamics and dye photophysics in single-molecule FRET experiments.
Chung HS, Louis JM, Eaton WA.
Biophys J (2010 Feb 17) 98:696-706. Abstract/Full Text
Evidence for a partially structured state of the amylin monomer.
Vaiana SM, Best RB, Yau WM, Eaton WA, Hofrichter J.
Biophys J (2009 Dec 2) 97:2948-57. Abstract/Full Text
Experimental determination of upper bound for transition path times in protein folding from single-molecule photon-by-photon trajectories.
Chung HS, Louis JM, Eaton WA.
Proc Natl Acad Sci U S A (2009 Jul 21) 106:11837-44. Abstract/Full Text
Chemical, physical, and theoretical kinetics of an ultrafast folding protein.
Kubelka J, Henry ER, Cellmer T, Hofrichter J, Eaton WA.
Proc Natl Acad Sci U S A (2008 Dec 2) 105:18655-62. Abstract/Full Text
Measuring internal friction of an ultrafast-folding protein.
Cellmer T, Henry ER, Hofrichter J, Eaton WA.
Proc Natl Acad Sci U S A (2008 Nov 25) 105:18320-5. Abstract/Full Text
Estimating free-energy barrier heights for an ultrafast folding protein from calorimetric and kinetic data.
Godoy-Ruiz R, Henry ER, Kubelka J, Hofrichter J, Muñoz V, Sanchez-Ruiz JM, Eaton WA.
J Phys Chem B (2008 May 15) 112:5938-49. Abstract/Full Text
A tribute to Attila Szabo.
Eaton WA, Hummer G, Zwanzig RW.
J Phys Chem B (2008 May 15) 112:5881-91. Abstract/Full Text
Sedimentation studies on human amylin fail to detect low-molecular-weight oligomers.
Vaiana SM, Ghirlando R, Yau WM, Eaton WA, Hofrichter J.
Biophys J (2008 Apr 1) 94:L45-7. Abstract/Full Text
Protein folding studied by single-molecule FRET.
Schuler B, Eaton WA.
Curr Opin Struct Biol (2008 Feb) 18:16-26. Abstract/Full Text
Relaxation rate for an ultrafast folding protein is independent of chemical denaturant concentration.
Cellmer T, Henry ER, Kubelka J, Hofrichter J, Eaton WA.
J Am Chem Soc (2007 Nov 28) 129:14564-5. Abstract/Full Text
Effect of flexibility and cis residues in single-molecule FRET studies of polyproline.
Best RB, Merchant KA, Gopich IV, Schuler B, Bax A, Eaton WA.
Proc Natl Acad Sci U S A (2007 Nov 27) 104:18964-9. Abstract/Full Text
Evolution of allosteric models for hemoglobin.
Eaton WA, Henry ER, Hofrichter J, Bettati S, Viappiani C, Mozzarelli A.
IUBMB Life (2007 Aug-Sep) 59:586-99. Abstract/Full Text
Characterizing the unfolded states of proteins using single-molecule FRET spectroscopy and molecular simulations.
Merchant KA, Best RB, Louis JM, Gopich IV, Eaton WA.
Proc Natl Acad Sci U S A (2007 Jan 30) 104:1528-33. Abstract/Full Text
Effects of denaturants on the dynamics of loop formation in polypeptides.
Buscaglia M, Lapidus LJ, Eaton WA, Hofrichter J.
Biophys J (2006 Jul 1) 91:276-88. Abstract/Full Text
Folding and aggregation kinetics of a beta-hairpin.
Muñoz V, Ghirlando R, Blanco FJ, Jas GS, Hofrichter J, Eaton WA.
Biochemistry (2006 Jun 13) 45:7023-35. Abstract/Full Text
Sub-microsecond protein folding.
Kubelka J, Chiu TK, Davies DR, Eaton WA, Hofrichter J.
J Mol Biol (2006 Jun 9) 359:546-53. Abstract/Full Text
Latent structure of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition personality disorder criteria.
Nestadt G, Hsu FC, Samuels J, Bienvenu OJ, Reti I, Costa PT Jr, Eaton WW.
Compr Psychiatry (2006 Jan-Feb) 47:54-62. Abstract/Full Text
Internet-based mental health interventions.
Ybarra ML, Eaton WW.
Ment Health Serv Res (2005 Jun) 7:75-87. Abstract/Full Text
High-resolution x-ray crystal structures of the villin headpiece subdomain, an ultrafast folding protein.
Chiu TK, Kubelka J, Herbst-Irmer R, Eaton WA, Hofrichter J, Davies DR.
Proc Natl Acad Sci U S A (2005 May 24) 102:7517-22. Abstract/Full Text
Determination of ultrafast protein folding rates from loop formation dynamics.
Buscaglia M, Kubelka J, Eaton WA, Hofrichter J.
J Mol Biol (2005 Apr 1) 347:657-64. Abstract/Full Text
Polyproline and the "spectroscopic ruler" revisited with single-molecule fluorescence.
Schuler B, Lipman EA, Steinbach PJ, Kumke M, Eaton WA.
Proc Natl Acad Sci U S A (2005 Feb 22) 102:2754-9. Abstract/Full Text
Understanding the shape of sickled red cells.
Christoph GW, Hofrichter J, Eaton WA.
Biophys J (2005 Feb) 88:1371-6. Abstract/Full Text
New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels.
Viappiani C, Bettati S, Bruno S, Ronda L, Abbruzzetti S, Mozzarelli A, Eaton WA.
Proc Natl Acad Sci U S A (2004 Oct 5) 101:14414-9. Abstract/Full Text
The protein folding 'speed limit'.
Kubelka J, Hofrichter J, Eaton WA.
Curr Opin Struct Biol (2004 Feb) 14:76-88. Abstract/Full Text
Kinetics of intramolecular contact formation in a denatured protein.
Buscaglia M, Schuler B, Lapidus LJ, Eaton WA, Hofrichter J.
J Mol Biol (2003 Sep 5) 332:9-12. Abstract/Full Text
Single-molecule measurement of protein folding kinetics.
Lipman EA, Schuler B, Bakajin O, Eaton WA.
Science (2003 Aug 29) 301:1233-5. Abstract/Full Text
Experimental tests of villin subdomain folding simulations.
Kubelka J, Eaton WA, Hofrichter J.
J Mol Biol (2003 Jun 13) 329:625-30. Abstract/Full Text
Linus Pauling and sickle cell disease.
Eaton WA.
Biophys Chem (2003) 100:109-16. Abstract/Full Text
Probing the free-energy surface for protein folding with single-molecule fluorescence spectroscopy.
Schuler B, Lipman EA, Eaton WA.
Nature (2002 Oct 17) 419:743-7. Abstract/Full Text
A tertiary two-state allosteric model for hemoglobin.
Henry ER, Bettati S, Hofrichter J, Eaton WA.
Biophys Chem (2002 Jul 10) 98:149-64. Abstract/Full Text
Measuring dynamic flexibility of the coil state of a helix-forming peptide.
Lapidus LJ, Eaton WA, Hofrichter J.
J Mol Biol (2002 May 24) 319:19-25. Abstract/Full Text