Publications

A selection of recent and significant publications can be viewed below.

Select Publications

Toggling between food-seeking and self-preservation behaviors via hypothalamic response networks.: de Araujo Salgado I, Li C, Burnett CJ, Rodriguez Gonzalez S, Becker JJ, Horvath A, Earnest T, Kravitz AV, Krashes MJ.; Neuron (2023 Sep 20) 111:2899-2917.e6. Abstract/Full Text
AgRP neurons coordinate the mitigation of activity-based anorexia.: Sutton Hickey AK, Duane SC, Mickelsen LE, Karolczak EO, Shamma AM, Skillings A, Li C, Krashes MJ.; Mol Psychiatry (2023 Apr) 28:1622-1635. Abstract/Full Text
Examining the role of olfaction in dietary choice.: Boone MH, Liang-Guallpa J, Krashes MJ.; Cell Rep (2021 Feb 16) 34:108755. Abstract/Full Text
High-fat food biases hypothalamic and mesolimbic expression of consummatory drives.: Mazzone CM, Liang-Guallpa J, Li C, Wolcott NS, Boone MH, Southern M, Kobzar NP, Salgado IA, Reddy DM, Sun F, Zhang Y, Li Y, Cui G, Krashes MJ.; Nat Neurosci (2020 Oct) 23:1253-1266. Abstract/Full Text
Need-based prioritization of behavior.: Burnett CJ, Funderburk SC, Navarrete J, Sabol A, Liang-Guallpa J, Desrochers TM, Krashes MJ.; Elife (2019 Mar 25) 8. Abstract/Full Text

Additional Publications

Natural locus coeruleus dynamics during feeding.: Sciolino NR, Hsiang M, Mazzone CM, Wilson LR, Plummer NW, Amin J, Smith KG, McGee CA, Fry SA, Yang CX, Powell JM, Bruchas MR, Kravitz AV, Cushman JD, Krashes MJ, Cui G, Jensen P.; Sci Adv (2022 Aug 19) 8:eabn9134. Abstract/Full Text
Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding.: Alcantara IC, Tapia APM, Aponte Y, Krashes MJ.; Nat Metab (2022 Jul) 4:836-847. Abstract/Full Text
A discrete parasubthalamic nucleus subpopulation plays a critical role in appetite suppression.: Kim JH, Kromm GH, Barnhill OK, Sperber J, Heuer LB, Loomis S, Newman MC, Han K, Gulamali FF, Legan TB, Jensen KE, Funderburk SC, Krashes MJ, Carter ME.; Elife (2022 May 4) 11. Abstract/Full Text
A distinct hypothalamus-to-β cell circuit modulates insulin secretion.: Papazoglou I, Lee JH, Cui Z, Li C, Fulgenzi G, Bahn YJ, Staniszewska-Goraczniak HM, Piñol RA, Hogue IB, Enquist LW, Krashes MJ, Rane SG.; Cell Metab (2022 Feb 1) 34:285-298.e7. Abstract/Full Text
Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives.: Grieco F, Bernstein BJ, Biemans B, Bikovski L, Burnett CJ, Cushman JD, van Dam EA, Fry SA, Richmond-Hacham B, Homberg JR, Kas MJH, Kessels HW, Koopmans B, Krashes MJ, Krishnan V, Logan S, Loos M, McCann KE, Parduzi Q, Pick CG, Prevot TD, Riedel G, Robinson L, Sadighi M, Smit AB, Sonntag W, Roelofs RF, Tegelenbosch RAJ, Noldus LPJJ.; Front Behav Neurosci (2021) 15:735387. Abstract/Full Text
Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways.: Piñol RA, Mogul AS, Hadley CK, Saha A, Li C, Škop V, Province HS, Xiao C, Gavrilova O, Krashes MJ, Reitman ML.; Cell Metab (2021 Jul 6) 33:1389-1403.e6. Abstract/Full Text
Food cue regulation of AGRP hunger neurons guides learning.: Berrios J, Li C, Madara JC, Garfield AS, Steger JS, Krashes MJ, Lowell BB.; Nature (2021 Jul) 595:695-700. Abstract/Full Text
An open-source device for measuring food intake and operant behavior in rodent home-cages.: Matikainen-Ankney BA, Earnest T, Ali M, Casey E, Wang JG, Sutton AK, Legaria AA, Barclay KM, Murdaugh LB, Norris MR, Chang YH, Nguyen KP, Lin E, Reichenbach A, Clarke RE, Stark R, Conway SM, Carvalho F, Al-Hasani R, McCall JG, Creed MC, Cazares V, Buczynski MW, Krashes MJ, Andrews ZB, Kravitz AV.; Elife (2021 Mar 29) 10. Abstract/Full Text
Integrating Hunger with Rival Motivations.: Sutton AK, Krashes MJ.; Trends Endocrinol Metab (2020 Jul) 31:495-507. Abstract/Full Text
MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance.: Al-Massadi O, Quiñones M, Clasadonte J, Hernandez-Bautista R, Romero-Picó A, Folgueira C, Morgan DA, Kalló I, Heras V, Senra A, Funderburk SC, Krashes MJ, Souto Y, Fidalgo M, Luquet S, Chee MJ, Imbernon M, Beiroa D, García-Caballero L, Gallego R, Lam BYH, Yeo G, Lopez M, Liposits Z, Rahmouni K, Prevot V, Dieguez C, Nogueiras R.; Diabetes (2019 Dec) 68:2210-2222. Abstract/Full Text
The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits.: Li MM, Madara JC, Steger JS, Krashes MJ, Balthasar N, Campbell JN, Resch JM, Conley NJ, Garfield AS, Lowell BB.; Neuron (2019 May 8) 102:653-667.e6. Abstract/Full Text
Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State.: Li C, Navarrete J, Liang-Guallpa J, Lu C, Funderburk SC, Chang RB, Liberles SD, Olson DP, Krashes MJ.; Cell Metab (2019 Mar 5) 29:681-694.e5. Abstract/Full Text
Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure, and heart rate, but not food intake.: Piñol RA, Zahler SH, Li C, Saha A, Tan BK, Škop V, Gavrilova O, Xiao C, Krashes MJ, Reitman ML.; Nat Neurosci (2018 Nov) 21:1530-1540. Abstract/Full Text
DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo.: Thompson KJ, Khajehali E, Bradley SJ, Navarrete JS, Huang XP, Slocum S, Jin J, Liu J, Xiong Y, Olsen RHJ, Diberto JF, Boyt KM, Pina MM, Pati D, Molloy C, Bundgaard C, Sexton PM, Kash TL, Krashes MJ, Christopoulos A, Roth BL, Tobin AB.; ACS Pharmacol Transl Sci (2018 Sep 14) 1:61-72. Abstract/Full Text
AgRP Accountants Compute Caloric Cost.: Liang J, Krashes MJ.; Cell Rep (2017 Dec 5) 21:2647-2648. Abstract/Full Text
Asprosin is a centrally acting orexigenic hormone.: Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, Saha PK, Lee ME, Phillips KJ, Jain M, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, Sutton VR, Moore DD, Butte NF, Krashes MJ, Xu Y, Chopra AR.; Nat Med (2017 Dec) 23:1444-1453. Abstract/Full Text
Specialized Mechanosensory Nociceptors Mediating Rapid Responses to Hair Pull.: Ghitani N, Barik A, Szczot M, Thompson JH, Li C, Le Pichon CE, Krashes MJ, Chesler AT.; Neuron (2017 Aug 16) 95:944-954.e4. Abstract/Full Text
Dynamic GABAergic afferent modulation of AgRP neurons.: Garfield AS, Shah BP, Burgess CR, Li MM, Li C, Steger JS, Madara JC, Campbell JN, Kroeger D, Scammell TE, Tannous BA, Myers MG Jr, Andermann ML, Krashes MJ, Lowell BB.; Nat Neurosci (2016 Dec) 19:1628-1635. Abstract/Full Text
Hunger-Driven Motivational State Competition.: Burnett CJ, Li C, Webber E, Tsaousidou E, Xue SY, Brüning JC, Krashes MJ.; Neuron (2016 Oct 5) 92:187-201. Abstract/Full Text
Neuroendocrinology: Electromagnetic control of neural activity - prospective physics for physicians.: Funderburk SC, Krashes MJ.; Nat Rev Endocrinol (2016 May 12) 12:316-7. Abstract/Full Text
Acute Glucose Response Properties Beyond Feeding.: Burnett CJ, Krashes MJ.; Trends Mol Med (2016 May) 22:356-358. Abstract/Full Text
Foraging and flight trump defense and fight.: Li C, Krashes MJ.; Nat Neurosci (2016 Apr 26) 19:645-646. Abstract/Full Text
Melanocortin-4 receptor-regulated energy homeostasis.: Krashes MJ, Lowell BB, Garfield AS.; Nat Neurosci (2016 Feb) 19:206-19. Abstract/Full Text
Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.: Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu O, Smith AS, Jain S, Lowell BB, Krashes MJ, Wess J.; Nat Commun (2016 Jan 8) 7:10268. Abstract/Full Text
Palatability Can Drive Feeding Independent of AgRP Neurons.: Denis RG, Joly-Amado A, Webber E, Langlet F, Schaeffer M, Padilla SL, Cansell C, Dehouck B, Castel J, Delbès AS, Martinez S, Lacombe A, Rouch C, Kassis N, Fehrentz JA, Martinez J, Verdié P, Hnasko TS, Palmiter RD, Krashes MJ, Güler AD, Magnan C, Luquet S.; Cell Metab (2015 Oct 6) 22:646-57. Abstract/Full Text
The elegance of energy balance: Insight from circuit-level manipulations.: Webber ES, Bonci A, Krashes MJ.; Synapse (2015 Sep) 69:461-74. Abstract/Full Text
A neural basis for melanocortin-4 receptor-regulated appetite.: Garfield AS, Li C, Madara JC, Shah BP, Webber E, Steger JS, Campbell JN, Gavrilova O, Lee CE, Olson DP, Elmquist JK, Tannous BA, Krashes MJ, Lowell BB.; Nat Neurosci (2015 Jun) 18:863-71. Abstract/Full Text
A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.: Vardy E, Robinson JE, Li C, Olsen RHJ, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, Mosier PD, Song J, Kash TL, Malanga CJ, Krashes MJ, Roth BL.; Neuron (2015 May 20) 86:936-946. Abstract/Full Text
MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus.: Shah BP, Vong L, Olson DP, Koda S, Krashes MJ, Ye C, Yang Z, Fuller PM, Elmquist JK, Lowell BB.; Proc Natl Acad Sci U S A (2014 Sep 9) 111:13193-8. Abstract/Full Text
An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.: Krashes MJ, Shah BP, Madara JC, Olson DP, Strochlic DE, Garfield AS, Vong L, Pei H, Watabe-Uchida M, Uchida N, Liberles SD, Lowell BB.; Nature (2014 Mar 13) 507:238-42. Abstract/Full Text
Optogenetic and chemogenetic insights into the food addiction hypothesis.: Krashes MJ, Kravitz AV.; Front Behav Neurosci (2014) 8:57. Abstract/Full Text
Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP.: Krashes MJ, Shah BP, Koda S, Lowell BB.; Cell Metab (2013 Oct 1) 18:588-95. Abstract/Full Text
Layered reward signalling through octopamine and dopamine in Drosophila.: Burke CJ, Huetteroth W, Owald D, Perisse E, Krashes MJ, Das G, Gohl D, Silies M, Certel S, Waddell S.; Nature (2012 Dec 20) 492:433-7. Abstract/Full Text
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.: Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, Maratos-Flier E, Roth BL, Lowell BB.; J Clin Invest (2011 Apr) 121:1424-8. Abstract/Full Text
A neural circuit mechanism integrating motivational state with memory expression in Drosophila.: Krashes MJ, DasGupta S, Vreede A, White B, Armstrong JD, Waddell S.; Cell (2009 Oct 16) 139:416-27. Abstract/Full Text
Sequential use of mushroom body neuron subsets during drosophila odor memory processing.: Krashes MJ, Keene AC, Leung B, Armstrong JD, Waddell S.; Neuron (2007 Jan 4) 53:103-15. Abstract/Full Text