Workshop on Developing Precision Medicine Approaches to the Treatment of Severe Obesity in Adolescents: Research Gaps and Opportunities

Event Details

Background

Severe obesity in adolescents is a growing and serious concern and is associated with significant physical and psychological co-morbidities. Response to behavioral and lifestyle interventions generally show relatively small improvements in BMI that are not sustained, and the limited pharmacotherapy options available also show modest efficacy. Bariatric surgery leads to the greatest and most sustained weight loss; however, it can be associated with considerable short and long term health risks, and despite surgical intervention, many adolescents continue to have severe obesity. Little is known regarding which treatment approaches will promote meaningful and sustained weight loss in adolescents with severe obesity or how to target such treatments to maximize efficacy.

Meeting Objectives

This workshop will bring together scientists with expertise in genetics, pediatric obesity, endocrinology, epidemiology, psychology, behavioral medicine, adolescent medicine, bariatric surgery, and other disciplines to discuss and identify 1) what is known regarding the epidemiology and biopsychosocial determinants of severe obesity in adolescents, 2) what is known regarding effectiveness of treatments for severe obesity in adolescents and predictors of response, and 3) gaps and opportunities for future research to develop more effective and targeted treatments for adolescents with severe obesity. The goal of this trans-NIH workshop is to accelerate research that will identify which treatment approaches will be most beneficial for specific patients based on a better understanding of individual differences in genetic endowment, clinical, metabolic, psychological, and behavioral phenotypes, and response to environmental exposures.

Workshop Booklet (PDF, 794.31 KB) .

Organizing Committee

Chairs

Aaron S. Kelly, Ph.D.
Associate Professor of Pediatrics and Medicine
University of Minnesota Medical School
University of Minnesota Masonic Children's Hospital

Marsha D. Marcus, Ph.D.
Professor of Psychiatry and Psychology
University of Pittsburgh School of Medicine
Western Psychiatric Institute and Clinic

Jack A. Yanovski, M.D. Ph.D.
Chief of the Section on Growth and Obesity
Program on Developmental Endocrinology and Genetics
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health

NIH Members

NIDDK

Voula Osganian, M.D., Sc.D., M.P.H.
Andrew Bremer, M.D.
Mary Evans, Ph.D.
Christine Hunter, Ph.D., ABPP
Robert Kuczmarski, Ph.D.
Barbara Linder, M.D., Ph.D.
Pamela Thornton, Ph.D.
Susan Yanovski, M.D.

NICHD

Layla Esposito, Ph.D., M.A.

NHLBI

Charlotte Pratt, Ph.D., R.D.

OBSSR

Deborah Young-Hyman, Ph.D.

ODP

Rachel Ballad, M.D., M.P.H.

Registration Deadline

September 1, 2017 or until full.

To register, RSVP to Lauren Meskill via email with your name, affiliation and phone number.

Agenda

September 18, 2017

7:30 a.m. – 8:15 a.m.

Registration

8:15 a.m. – 8:20 a.m.

Welcoming Remarks
Griffin P. Rodgers, MD, MACP, National Institute of Diabetes and Digestive and Kidney Diseases

8:20 a.m. – 8:30 a.m.

Introduction and Workshop Goals
Voula Osganian, MD, ScD, National Institute of Diabetes and Digestive and Kidney Diseases

Session I: Scope of the Problem: Severe Obesity and the Adolescent

Moderator: Robert Kuczmarski, PhD, National Institute of Diabetes and Digestive and Kidney Diseases

8:30 a.m. – 8:50 a.m.

Epidemiology of Severe Obesity in Adolescents
Cynthia Ogden, PhD, Centers for Disease Control and Prevention

8:50 a.m. – 9:10 a.m.

Adolescent Development
Margaret Zeller, PhD, Cincinnati Children's Hospital Medical Center

9:10 a.m. – 9:40 a.m.

Question and Answer Panel

9:40 a.m. – 10:10 a.m.

Break

Session II: Biopsychosocial and Behavioral Factors that are Associated with the Development of Severe Obesity in Adolescents

Moderator: Deborah Hyman-Young, PhD, Office of Behavioral and Social Sciences Research Office of the Director

10:10 a.m. – 10:35 a.m.

Psychosocial, Behavioral and Environmental Risk Factors
Elissa Jelalian, PhD, Alpert Medical School of Brown University

10:35 a.m. – 11:00 a.m.

Genetics and Epigenetics
Sadaf Farooqi, MBChB, PhD, University of Cambridge

11:00 a.m. – 11:25 a.m.

Hedonic Eating, Food Reward and Appetite
Ania Jastreboff, MD, PhD, Yale University School of Medicine

11:25 a.m. – 11:55 a.m.

Question and Answer Panel

11:55 a.m. – 12:45 p.m.

Lunch

Session III: Treatment Approaches for Severe Obesity in Adolescents

Moderator: Charlotte Pratt, PhD, National Heart, Lung, and Blood Institute

12:45 p.m. – 1:05 p.m.

Lifestyle and Behavioral Interventions
Marsha Marcus, PhD, University of Pittsburgh School of Medicine

1:05 p.m. – 1:25 p.m.

POWER Clinical Registry- Clinical Experience and Health Outcomes
Shelley Kirk, PhD, RD, LD, Cincinnati Children's Hospital Medical Center

1:25 p.m. – 1:45 p.m.

Pharmacologic Interventions
Aaron Kelly, PhD, University of Minnesota Medical School

1:45 p.m. – 2:05 p.m.

Surgical Interventions
Thomas Inge, MD, PhD, Children's Hospital Colorado

2:05 p.m. – 2:25 p.m.

Emerging Therapies
Lee Kaplan, MD, PhD, Harvard Medical School

2:25 p.m. – 2:45 p.m.

Developing and testing a Chronic Care Model for the adolescent with severe obesity
Stephen Cook, MD, MPH, University of Rochester Medical Center

2:45 p.m. – 3:15 p.m.

Question and Answer Panel

3:15 p.m. – 3:45 p.m.

Break

Session IV: Biomarkers and Phenotypes that Predict Response to Treatment in Adolescents with Severe Obesity

Moderator: Barbara Linder, MD, Ph.D., National Institute of Diabetes and Digestive and Kidney Diseases

3:45 p.m. – 4:05 p.m.

Eating Behaviors and Psychological Phenotypes/Factors
Kerri Boutelle, PhD, University of California, San Diego School of Medicine

4:05 p.m. – 4:25 p.m.

Physical Activity Phenotypes/Factors
Molly Bray, PhD, RD, LD, The University of Texas at Austin

4:25 p.m. – 4:45 p.m.

Biomarkers
Charles Burant, MD, PhD, University of Michigan

4:45 p.m. – 5:15 p.m.

Question and Answer Panel

5:15 p.m.

Closing Remarks Day 1 from Co-Chairs

September 19, 2017

8:00 a.m. – 8:15 a.m.

Opening Remarks and Goals for Day 2
Voula Osganian, MD, ScD, National Institute of Diabetes and Digestive and Kidney Diseases

8:15 a.m. – 9:30 a.m.

Breakout Sessions

1. Epidemiology and Subgroups at Risk including Disparities and Special Populations
   
   Leader: Cynthia Ogden, PhD, Centers for Disease Control and Prevention
   Facilitator: Pamela Thornton, PhD, National Institute of Diabetes and Digestive and Kidney Diseases
2. Biopsychosocial and Behavioral Factors Associated with the Development of Severe Obesity
   
   Leader: Elissa Jelalian, PhD, Alpert Medical School of Brown University
   Facilitator: Mary Evans, PhD, National Institute of Diabetes and Digestive and Kidney Diseases
3. Treatment Approaches for Severe Obesity in Adolescents
   
   Leader: Stephen Cook, MD, MPH, University of Rochester Medical Center
   Facilitator: Barbara Linder, MD, PhD, National Institute of Diabetes and Digestive and Kidney Diseases
4. Biomarkers and Phenotypes that Predict Response to Treatment
   
   Leader: Charles Burant, MD, PhD, University of Michigan
   Facilitator: Sue Yanovski, MD, National Institute of Diabetes and Digestive and Kidney Diseases

9:30 a.m. – 9:45 a.m.

Break

9:45 a.m. – 10:45 a.m.

Breakout Session Subgroup Presentations by Leaders (15 min each)

10:45 a.m. – 11:45 a.m.

Full Group Panel Discussion led by Co-Chairs

11:45 a.m. – 12:15 p.m.

Workshop Summary and Recommendations with Concluding Remarks from Co-Chairs

12:15 p.m.

Wrap up and Adjournment
Voula Osganian, MD, ScD, National Institute of Diabetes and Digestive and Kidney Diseases