Workshop on Developing Precision Medicine Approaches to the Treatment of Severe Obesity in Adolescents: Research Gaps and Opportunities
Severe obesity in adolescents is a growing and serious concern and is associated with significant physical and psychological co-morbidities. Response to behavioral and lifestyle interventions generally show relatively small improvements in BMI that are not sustained, and the limited pharmacotherapy options available also show modest efficacy. Bariatric surgery leads to the greatest and most sustained weight loss; however, it can be associated with considerable short and long term health risks, and despite surgical intervention, many adolescents continue to have severe obesity. Little is known regarding which treatment approaches will promote meaningful and sustained weight loss in adolescents with severe obesity or how to target such treatments to maximize efficacy.
This workshop will bring together scientists with expertise in genetics, pediatric obesity, endocrinology, epidemiology, psychology, behavioral medicine, adolescent medicine, bariatric surgery, and other disciplines to discuss and identify 1) what is known regarding the epidemiology and biopsychosocial determinants of severe obesity in adolescents, 2) what is known regarding effectiveness of treatments for severe obesity in adolescents and predictors of response, and 3) gaps and opportunities for future research to develop more effective and targeted treatments for adolescents with severe obesity. The goal of this trans-NIH workshop is to accelerate research that will identify which treatment approaches will be most beneficial for specific patients based on a better understanding of individual differences in genetic endowment, clinical, metabolic, psychological, and behavioral phenotypes, and response to environmental exposures.
Workshop Booklet (PDF, 794.31 KB) .
Aaron S. Kelly, Ph.D.
Associate Professor of Pediatrics and Medicine
University of Minnesota Medical School
University of Minnesota Masonic Children's Hospital
Marsha D. Marcus, Ph.D.
Professor of Psychiatry and Psychology
University of Pittsburgh School of Medicine
Western Psychiatric Institute and Clinic
Jack A. Yanovski, M.D. Ph.D.
Chief of the Section on Growth and Obesity
Program on Developmental Endocrinology and Genetics
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health
Voula Osganian, M.D., Sc.D., M.P.H.
Andrew Bremer, M.D.
Mary Evans, Ph.D.
Christine Hunter, Ph.D., ABPP
Robert Kuczmarski, Ph.D.
Barbara Linder, M.D., Ph.D.
Pamela Thornton, Ph.D.
Susan Yanovski, M.D.
Layla Esposito, Ph.D., M.A.
Charlotte Pratt, Ph.D., R.D.
Deborah Young-Hyman, Ph.D.
Rachel Ballad, M.D., M.P.H.
September 1, 2017 or until full.
To register, RSVP to Lauren Meskill via email with your name, affiliation and phone number.