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Renewal of KPMP/KPMI - Kidney Precision Medicine Project

June 2025 Council

Lead Division/Office

KUH

Point(s) of Contact

Debbie Gipson, M.D., M.S.; Chris Ketchum, Ph.D.; Ivonne Schulman, M.D.; Eric Brunskill, Ph.D.; Afshin Parsa, M.D., M.P.H.; Tracy Rankin, Ph.D., M.P.H.; Daniel Gossett, Ph.D.

Executive Summary

The Kidney Precision Medicine Project (KPMP) was started in FY2017 with the vision to safely and ethically collect and interrogate human kidney biopsy tissue to discover novel molecular pathways that promote Chronic Kidney Diseases (CKDs) or Acute Kidney Injuries (AKIs). It was expanded in FY2022 to enhance participant recruitment and tissue interrogation.

Consistent with the recommendation of an External Evaluation Committee (2/14/2025), the NIDDK proposes to extend the KPMP for 5 years. This extension will allow the KPMP to (1) honor its commitment to existing enrollees (~500) by continuing robust longitudinal clinical molecular interrogation and follow-up, and (3) accelerate the discovery and validation of novel pathways, targets, and disease subgroups by directly supporting the efforts of the broader research community to fully leverage KPMP data.