Approved Concepts for Requests for Applications (RFAs), Program Announcements (PAs), and Requests for Proposals (RFPs)
Concepts represent an early planning stage for potential NIDDK initiatives and describe their basic purpose, scope, and objectives. Through the Concept Clearance process, NIDDK receives input from the NIDDK Advisory Council regarding the merits of research concepts. Council approval of a concept does not guarantee it will become a funded initiative; that decision is made based on scientific and programmatic priorities and the availability of funds.
Concepts presented to the NIDDK Advisory Council will be posted on the NIDDK website to enhance transparency and make the NIDDK research community aware of potential initiatives. The resultant initiative, in the form of program announcements (PA/PAR/PAS), requests for applications (RFA), and requests for proposals (RFP), may differ from the concepts in the final wording of the titles or other programmatic or scientific aspects.
Accelerating Medicines Partnership in Type 2 Diabetes (AMP T2D) Renewal
This concept proposes to continue the pre-competitive collaboration embodied in the AMP T2D program and aims to (1) improve understanding of the genetic architecture of T2D and its complications; (2) identify, validate, and perturb disease-driving networks; and (3) make the resulting knowledge broadly available to the scientific community to foster fundamental and clinical research and nominate potential biomarkers and drug discovery targets.
Catalyst Award in Diabetes, Endocrinology and Metabolic Diseases
This concept seeks to foster paradigm shifting research that applies emerging technologies to Diabetes, Endocrinology and Metabolic Diseases (DDEMD) scientific areas or that addresses bold concepts not yet supported by substantial preliminary data.
Centers of Excellence in Hematology Renewal
This concept proposes to continue to foster multi-disciplinary research, collaboration, and resources supporting hematology research.
Food Insecurity and HIV
The goal of this concept is to improve health outcomes for people with HIV or people at risk for HIV by understanding how food insecurity and other important determinants of health impact health seeking behavior and treatment adherence to antiretroviral therapy.
Molecular Mechanisms of Metabolic Adaptation to Weight Change
This concept seeks to explore the extent, duration, and potential mechanisms for metabolic adaptation following weight loss, which may contribute to the difficulty many experience in maintaining weight loss.
National Survey on Prevalence of Kidney Disease (NHANES)
The goal of this proposal is to provide support for the National Health and Nutritional Survey. Among other features, this survey has served as the key indicator of the prevalence of chronic kidney disease in the United States for more than 20 years.
NIDDK’s Therapeutics Discovery Translational Pipeline
This concept proposes to continue the Therapeutics Discovery Translational Pipeline with a focus on novelty, innovation, and therapeutics where there is clear, unmet clinical need. This Pipeline stimulates research and technology development to pharmacologically validate novel drug targets and/or small molecule chemical scaffolds or non-viral biologics that are not currently a focus within the biotechnology and pharmaceutical industries.
Obesity and HIV
This concept seeks to elucidate antiretroviral agent-mediated obesogenic processes in the context of people at risk for HIV on pre-exposure, by mechanistic interrogation of both viral-mediated and antiretroviral agent-mediated changes in fat biology, inflammation, and metabolism.
Optimization of NIDDK Investment in Large Research Programs
This concept proposes an updated strategy to promote effective, collaborative research studies within the Institute’s mission.
Pathways for Review and Release of Available NIDDK Repository Samples
This concept seeks to provide a pathway for researchers to request access to valuable samples housed in the NIDDK Central Repository, allowing for access to requested samples based on scientific merit of the proposed project and the scarcity/abundance of the specific samples requested.
Polycystic Kidney Disease Center Program
This concept aims to develop an interactive consortium to foster research and training in Polycystic Kidney Disease (PKD) and disseminate research resources essential to the study of PKD to the research community.
Prevention of Lower Urinary Tract Research Consortium (PLUS) Renewal
This concept proposes to continue the successful PLUS consortium that is using qualitative and quantitative approaches to conduct studies to establish the scientific basis for future intervention studies promoting bladder health and/or preventing bladder conditions in adolescent and adult women.
(Re)Building a Kidney – A Grand Challenge Renewal
The long-term goal of this program is to develop and test advanced therapies for treatment of kidney injury or disease. This opportunity would support team of researchers representing diverse scientific disciplines to develop and test novel ways to stimulate regeneration or enhance productive repair in response to injury; or generate functional kidney tissue ex vivo for transplantation or engraftment.
Support of Emerging Physician Scientists to Develop Careers in Diabetes, Endocrinology, and Metabolic Diseases
This concept is proposed to pilot a program to enable continuity of research experiences for licensed or board-eligible MDs or MD-equivalents engaged in clinical or basic research within the Division of Diabetes, Endocrinology and Metabolic Diseases’ mission.
Supporting Descriptive Epidemiology of Non-Malignant Urologic Disease
The goal of this proposal is to provide a resource for the research, lay and clinical community of indicating the descriptive epidemiology of non-malignant urologic diseases, serving as a parallel resource to existing projects for chronic and end stage kidney disease within KUH, and for diabetes and digestive diseases within NIDDK.
Supporting Research in Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
This concept is proposed to improve mechanistic knowledge, diagnostic tests, and predictive measures for chronic pancreatic diseases and its complications, with the goal of supporting subsequent development of FDA approved specific treatments for pre-malignant diseases.
Supporting Transition to Independence for NIDDK Career Training Awardees
The goal of this proposal is to enhance capability of currently-funded career development award recipients (“K” awardees) to conduct research as they complete their transition to fully independent investigator status.
United States Renal Data System (USRDS)
The goal of this proposed initiative is to provide a data resource on incidence, prevalence, mortality, and cost of kidney disease in the United States, satisfying a Congressional legislative mandate (OBRA 1986). This resource would provide an invaluable resource for renal epidemiologists and colleagues in other government agencies, as well as providing a ready access to data for young investigators.