Concept Clearances
Approved Concepts for Requests for Applications (RFAs), Program Announcements (PAs), and Requests for Proposals (RFPs)
Concepts represent an early planning stage for potential NIDDK initiatives and describe their basic purpose, scope, and objectives. Through the Concept Clearance process, NIDDK receives input from the NIDDK Advisory Council regarding the merits of research concepts. Council approval of a concept does not guarantee it will become a funded initiative; that decision is made based on scientific and programmatic priorities and the availability of funds.
Concepts presented to the NIDDK Advisory Council will be posted on the NIDDK website to enhance transparency and make the NIDDK research community aware of potential initiatives. The resultant initiative, in the form of program announcements (PA/PAR/PAS), requests for applications (RFA), and requests for proposals (RFP), may differ from the concepts in the final wording of the titles or other programmatic or scientific aspects.
Concepts
January 2026
The purpose of the DiabDocs Program is to support the development of physicians committed to a career in diabetes research. The program thus far has supported...
The Diabetes Control and Complications Trial (DCCT, 1983-1993) compared intensive (aimed at near-normal glycemia) and conventional therapy in 1,441 participants with...
Despite significant advances in Type 1 Diabetes (T1D) research, there remains an urgent need for reliable and reproducible biomarkers that can capture the complexity of...
September 2025
Individuals with type 1 diabetes have a 2- to 4-fold higher risk of cardiovascular disease (CVD) compared to the general population. The mechanisms driving elevated risk...
Cardiovascular complications remain the leading cause of death among individuals with type 1 diabetes (T1D) and significantly reduce life expectancy. The underlying...
The CITR began in 2001 after the successful “Edmonton Trial” in 1999. It has pooled data from 47 programs. Through 2025, there were 1517 allograft recipients, 1363 autograft...
A major accomplishment of the Gastroparesis Clinical Research Consortium (GpCRC) was the creation of a large database with information on patients with symptoms of...
The purpose is to issue an RFA for the competing continuation of the Data Coordination Center of the Physiology of the Weight Reduced State (POWERS) clinical trial consortium...
The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) has led international efforts resulting in the identification of >300 IBD risk loci across...
This current NIDDK-wide initiative provides support services for the Epidemiology Coordinating Committee activities pertaining to the development and analysis of...
June 2025
The purpose of this proposal is to support research addressing barriers that limit progress toward
more effective open- and closed-loop diabetes control systems....
(Read More)
This is a proposal to extend the Congressionally mandated Diabetes Research Centers (DRC)
program that has been a prominent catalyst of diabetes research...
(Read More)
The Kidney Precision Medicine Project (KPMP) was started in FY2017 with the vision to safely and ethically collect and interrogate human kidney biopsy tissue...
(Read More)
May 2025
The Accelerating Medicines Partnership (AMP), is a pre-competitive collaboration among government, academia, and industry to improve the ongoing efforts...
This initiative concept is to support research in understanding how to engineer improved stem cell-derived islet cell products...
September 2024
The KUH Division of the NIDDK has worked to strengthen institutional training by creating highly connected cohorts of trainees...