Clifton Bogardus III, M.D.

Photo of Dr. Clifton Bogardus III
Scientific Focus Areas: Clinical Research, Epidemiology, Genetics and Genomics, Health Disparities

Publications

A selection of recent and significant publications can be viewed below.

Select Publications

Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians.
Thearle MS, Muller YL, Hanson RL, Mullins M, Abdussamad M, Tran J, Knowler WC, Bogardus C, Krakoff J, Baier LJ.
Diabetes (2012 Jan) 61:250-7. Abstract/Full Text
A genome-wide association study of BMI in American Indians.
Malhotra A, Kobes S, Knowler WC, Baier LJ, Bogardus C, Hanson RL.
Obesity (Silver Spring) (2011 Oct) 19:2102-6. Abstract/Full Text
Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans.
Jumpertz R, Le DS, Turnbaugh PJ, Trinidad C, Bogardus C, Gordon JI, Krakoff J.
Am J Clin Nutr (2011 Jul) 94:58-65. Abstract/Full Text
HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion.
Williams RC, Muller YL, Hanson RL, Knowler WC, Mason CC, Bian L, Ossowski V, Wiedrich K, Chen YF, Marcovina S, Hahnke J, Nelson RG, Baier LJ, Bogardus C.
Diabetologia (2011 Jul) 54:1684-92. Abstract/Full Text
Bimodal distribution of RNA expression levels in human skeletal muscle tissue.
Mason CC, Hanson RL, Ossowski V, Bian L, Baier LJ, Krakoff J, Bogardus C.
BMC Genomics (2011 Feb 7) 12:98. Abstract/Full Text

Additional Publications

A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians.
Piaggi P, Masindova I, Muller YL, Mercader J, Wiessner GB, Chen P, SIGMA Type 2 Diabetes Consortium., Kobes S, Hsueh WC, Mongalo M, Knowler WC, Krakoff J, Hanson RL, Bogardus C, Baier LJ.
Diabetes (2017 Aug) 66:2284-2295. Abstract/Full Text
T-cell receptor repertoire variation may be associated with type 2 diabetes mellitus in humans.
Frankl JA, Thearle MS, Desmarais C, Bogardus C, Krakoff J.
Diabetes Metab Res Rev (2016 Mar) 32:297-307. Abstract/Full Text
Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians.
Nair AK, Piaggi P, McLean NA, Kaur M, Kobes S, Knowler WC, Bogardus C, Hanson RL, Baier LJ.
Diabetologia (2016 Mar) 59:481-91. Abstract/Full Text
Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression.
Traurig M, Hanson RL, Marinelarena A, Kobes S, Piaggi P, Cole S, Curran JE, Blangero J, Göring H, Kumar S, Nelson RG, Howard BV, Knowler WC, Baier LJ, Bogardus C.
Diabetes (2016 Feb) 65:510-9. Abstract/Full Text
ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes.
Baier LJ, Muller YL, Remedi MS, Traurig M, Piaggi P, Wiessner G, Huang K, Stacy A, Kobes S, Krakoff J, Bennett PH, Nelson RG, Knowler WC, Hanson RL, Nichols CG, Bogardus C.
Diabetes (2015 Dec) 64:4322-32. Abstract/Full Text
Use of a High-Density Protein Microarray to Identify Autoantibodies in Subjects with Type 2 Diabetes Mellitus and an HLA Background Associated with Reduced Insulin Secretion.
Chang DC, Piaggi P, Hanson RL, Knowler WC, Bucci J, Thio G, Hohenadel MG, Bogardus C, Krakoff J.
PLoS One (2015) 10:e0143551. Abstract/Full Text
A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction.
Reinhardt M, Thearle MS, Ibrahim M, Hohenadel MG, Bogardus C, Krakoff J, Votruba SB.
Diabetes (2015 Aug) 64:2859-67. Abstract/Full Text
Salsalate has no effect on insulin secretion but decreases insulin clearance: a randomized, placebo-controlled trial in subjects without diabetes.
Penesova A, Koska J, Ortega E, Bunt JC, Bogardus C, de Courten B.
Diabetes Obes Metab (2015 Jun) 17:608-12. Abstract/Full Text
A cis-eQTL in PFKFB2 is associated with diabetic nephropathy, adiposity and insulin secretion in American Indians.
Muller YL, Piaggi P, Hanson RL, Kobes S, Bhutta S, Abdussamad M, Leak-Johnson T, Kretzler M, Huang K, Weil EJ, Nelson RG, Knowler WC, Bogardus C, Baier LJ.
Hum Mol Genet (2015 May 15) 24:2985-96. Abstract/Full Text
Fasting hyperglycemia predicts lower rates of weight gain by increased energy expenditure and fat oxidation rate.
Piaggi P, Thearle MS, Bogardus C, Krakoff J.
J Clin Endocrinol Metab (2015 Mar) 100:1078-87. Abstract/Full Text
Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.
Muller YL, Thearle MS, Piaggi P, Hanson RL, Hoffman D, Gene B, Mahkee D, Huang K, Kobes S, Votruba S, Knowler WC, Bogardus C, Baier LJ.
Hum Genet (2014 Nov) 133:1431-41. Abstract/Full Text
Assessing accuracy of genotype imputation in American Indians.
Malhotra A, Kobes S, Bogardus C, Knowler WC, Baier LJ, Hanson RL.
PLoS One (2014) 9:e102544. Abstract/Full Text
Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure.
Muller YL, Piaggi P, Hoffman D, Huang K, Gene B, Kobes S, Thearle MS, Knowler WC, Hanson RL, Baier LJ, Bogardus C.
Diabetologia (2014 Jul) 57:1382-90. Abstract/Full Text
Potential epigenetic dysregulation of genes associated with MODY and type 2 diabetes in humans exposed to a diabetic intrauterine environment: an analysis of genome-wide DNA methylation.
del Rosario MC, Ossowski V, Knowler WC, Bogardus C, Baier LJ, Hanson RL.
Metabolism (2014 May) 63:654-60. Abstract/Full Text
Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes.
Huang K, Nair AK, Muller YL, Piaggi P, Bian L, Del Rosario M, Knowler WC, Kobes S, Hanson RL, Bogardus C, Baier LJ.
Obesity (Silver Spring) (2014 Apr) 22:984-8. Abstract/Full Text
A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes.
Hanson RL, Muller YL, Kobes S, Guo T, Bian L, Ossowski V, Wiedrich K, Sutherland J, Wiedrich C, Mahkee D, Huang K, Abdussamad M, Traurig M, Weil EJ, Nelson RG, Bennett PH, Knowler WC, Bogardus C, Baier LJ.
Diabetes (2014 Jan) 63:369-76. Abstract/Full Text
Lower "awake and fed thermogenesis" predicts future weight gain in subjects with abdominal adiposity.
Piaggi P, Krakoff J, Bogardus C, Thearle MS.
Diabetes (2013 Dec) 62:4043-51. Abstract/Full Text
MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation.
Bian L, Traurig M, Hanson RL, Marinelarena A, Kobes S, Muller YL, Malhotra A, Huang K, Perez J, Gale A, Knowler WC, Bogardus C, Baier LJ.
Hum Mol Genet (2013 Nov 1) 22:4438-49. Abstract/Full Text
Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians.
Hanson RL, Guo T, Muller YL, Fleming J, Knowler WC, Kobes S, Bogardus C, Baier LJ.
Diabetes (2013 Aug) 62:2984-91. Abstract/Full Text
Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes.
Muller YL, Hanson RL, Knowler WC, Fleming J, Goswami J, Huang K, Traurig M, Sutherland J, Wiedrich C, Wiedrich K, Mahkee D, Ossowski V, Kobes S, Bogardus C, Baier LJ.
Hum Genet (2013 Jun) 132:697-707. Abstract/Full Text
Lower energy expenditure predicts long-term increases in weight and fat mass.
Piaggi P, Thearle MS, Bogardus C, Krakoff J.
J Clin Endocrinol Metab (2013 Apr) 98:E703-7. Abstract/Full Text
Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans.
Traurig MT, Orczewska JI, Ortiz DJ, Bian L, Marinelarena AM, Kobes S, Malhotra A, Hanson RL, Mason CC, Knowler WC, Bogardus C, Baier LJ.
Obesity (Silver Spring) (2013 Jan) 21:193-202. Abstract/Full Text
Variants in the LEPR gene are nominally associated with higher BMI and lower 24-h energy expenditure in Pima Indians.
Traurig MT, Perez JM, Ma L, Bian L, Kobes S, Hanson RL, Knowler WC, Krakoff JA, Bogardus C, Baier LJ.
Obesity (Silver Spring) (2012 Dec) 20:2426-30. Abstract/Full Text
Association analyses of variants in the DIO2 gene with early-onset type 2 diabetes mellitus in Pima Indians.
Nair S, Muller YL, Ortega E, Kobes S, Bogardus C, Baier LJ.
Thyroid (2012 Jan) 22:80-7. Abstract/Full Text
SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians.
Dong Y, Guo T, Traurig M, Mason CC, Kobes S, Perez J, Knowler WC, Bogardus C, Hanson RL, Baier LJ.
Mol Genet Metab (2011 Dec) 104:661-5. Abstract/Full Text
Evaluation of A2BP1 as an obesity gene.
Ma L, Hanson RL, Traurig MT, Muller YL, Kaur BP, Perez JM, Meyre D, Fu M, Körner A, Franks PW, Kiess W, Kobes S, Knowler WC, Kovacs P, Froguel P, Shuldiner AR, Bogardus C, Baier LJ.
Diabetes (2010 Nov) 59:2837-45. Abstract/Full Text
Analysis of the SIM1 contribution to polygenic obesity in the French population.
Ghoussaini M, Stutzmann F, Couturier C, Vatin V, Durand E, Lecoeur C, Degraeve F, Heude B, Tauber M, Hercberg S, Levy-Marchal C, Tounian P, Weill J, Traurig M, Bogardus C, Baier LJ, Michaud JL, Froguel P, Meyre D.
Obesity (Silver Spring) (2010 Aug) 18:1670-5. Abstract/Full Text
Effect of paternal diabetes on pre-diabetic phenotypes in adult offspring.
Penesova A, Bunt JC, Bogardus C, Krakoff J.
Diabetes Care (2010 Aug) 33:1823-8. Abstract/Full Text
Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish.
Muller YL, Hanson RL, Bian L, Mack J, Shi X, Pakyz R, Shuldiner AR, Knowler WC, Bogardus C, Baier LJ.
Diabetes (2010 Aug) 59:2080-5. Abstract/Full Text
Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians.
Bian L, Hanson RL, Muller YL, Ma L, MAGIC Investigators., Kobes S, Knowler WC, Bogardus C, Baier LJ.
Diabetologia (2010 Jul) 53:1349-53. Abstract/Full Text
Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians.
Bian L, Hanson RL, Ossowski V, Wiedrich K, Mason CC, Traurig M, Muller YL, Kobes S, Knowler WC, Baier LJ, Bogardus C.
Diabetes (2010 May) 59:1276-82. Abstract/Full Text
Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.
Prokopenko I, Zeggini E, Hanson RL, Mitchell BD, Rayner NW, Akan P, Baier L, Das SK, Elliott KS, Fu M, Frayling TM, Groves CJ, Gwilliam R, Scott LJ, Voight BF, Hattersley AT, Hu C, Morris AD, Ng M, Palmer CN, Tello-Ruiz M, Vaxillaire M, Wang CR, Stein L, Chan J, Jia W, Froguel P, Elbein SC, Deloukas P, Bogardus C, Shuldiner AR, McCarthy MI, International Type 2 Diabetes 1q Consortium..
Diabetes (2009 Jul) 58:1704-9. Abstract/Full Text
Common variation in SIM1 is reproducibly associated with BMI in Pima Indians.
Traurig M, Mack J, Hanson RL, Ghoussaini M, Meyre D, Knowler WC, Kobes S, Froguel P, Bogardus C, Baier LJ.
Diabetes (2009 Jul) 58:1682-9. Abstract/Full Text
Glucose allostasis: disrobing common wisdom.
Stumvoll M, Bogardus C.
Diabetologia (2009 May) 52:779-80. Abstract/Full Text
Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.
Rong R, Hanson RL, Ortiz D, Wiedrich C, Kobes S, Knowler WC, Bogardus C, Baier LJ.
Diabetes (2009 Feb) 58:478-88. Abstract/Full Text
Missing heritability and GWAS utility.
Bogardus C.
Obesity (Silver Spring) (2009 Feb) 17:209-10. Abstract/Full Text
Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant.
Krakoff J, Ma L, Kobes S, Knowler WC, Hanson RL, Bogardus C, Baier LJ.
Diabetes (2008 Dec) 57:3267-72. Abstract/Full Text
PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians.
Ma L, Hanson RL, Que LN, Guo Y, Kobes S, Bogardus C, Baier LJ.
Diabetes (2008 Nov) 57:3156-60. Abstract/Full Text
Association analysis of Krüppel-like factor 11 variants with type 2 diabetes in Pima Indians.
Ma L, Hanson RL, Que LN, Mack JL, Franks PW, Infante AM, Kobes S, Bogardus C, Baier LJ.
J Clin Endocrinol Metab (2008 Sep) 93:3644-9. Abstract/Full Text
Palmitate action to inhibit glycogen synthase and stimulate protein phosphatase 2A increases with risk factors for type 2 diabetes.
Mott DM, Stone K, Gessel MC, Bunt JC, Bogardus C.
Am J Physiol Endocrinol Metab (2008 Feb) 294:E444-50. Abstract/Full Text
Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals.
Koska J, Stefan N, Permana PA, Weyer C, Sonoda M, Bogardus C, Smith SR, Joanisse DR, Funahashi T, Krakoff J, Bunt JC.
Am J Clin Nutr (2008 Feb) 87:295-302. Abstract/Full Text
Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations.
Bunt JC, Krakoff J, Ortega E, Knowler WC, Bogardus C.
Diabetes Metab Res Rev (2007 May) 23:304-10. Abstract/Full Text
Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians.
Ma L, Hanson RL, Que LN, Cali AM, Fu M, Mack JL, Infante AM, Kobes S, International Type 2 Diabetes 1q Consortium., Bogardus C, Shuldiner AR, Baier LJ.
Diabetes (2007 May) 56:1454-9. Abstract/Full Text
Protein tyrosine phosphatase 1B is not a major susceptibility gene for type 2 diabetes mellitus or obesity among Pima Indians.
Traurig M, Hanson RL, Kobes S, Bogardus C, Baier LJ.
Diabetologia (2007 May) 50:985-9. Abstract/Full Text
Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons.
Ortega E, Pannacciulli N, Bogardus C, Krakoff J.
Am J Clin Nutr (2007 Feb) 85:440-5. Abstract/Full Text