Clifton Bogardus III, M.D.

Chief: Phoenix Epidemiology & Clinical Research Branch

Scientific Focus Areas: Clinical Research, Epidemiology, Genetics and Genomics, Health Disparities

clifton.bogardus@nih.gov 602-440-6571 Add to Contacts

Publications

A selection of recent and significant publications can be viewed below.

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Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians.

Nair AK, Traurig M, Sutherland JR, Muller YL, Grellinger ED, Saporito L, Nelson RG, Bogardus C, Baier LJ.

Cells (2022 Apr 25) 11. Abstract/Full Text

Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression.

Traurig M, Hanson RL, Marinelarena A, Kobes S, Piaggi P, Cole S, Curran JE, Blangero J, Göring H, Kumar S, Nelson RG, Howard BV, Knowler WC, Baier LJ, Bogardus C.

Diabetes (2016 Feb) 65:510-9. Abstract/Full Text

Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans.

Jumpertz R, Le DS, Turnbaugh PJ, Trinidad C, Bogardus C, Gordon JI, Krakoff J.

Am J Clin Nutr (2011 Jul) 94:58-65. Abstract/Full Text

ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes.

Baier LJ, Muller YL, Remedi MS, Traurig M, Piaggi P, Wiessner G, Huang K, Stacy A, Kobes S, Krakoff J, Bennett PH, Nelson RG, Knowler WC, Hanson RL, Nichols CG, Bogardus C.

Diabetes (2015 Dec) 64:4322-32. Abstract/Full Text

Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians.

Hanson RL, Guo T, Muller YL, Fleming J, Knowler WC, Kobes S, Bogardus C, Baier LJ.

Diabetes (2013 Aug) 62:2984-91. Abstract/Full Text

Additional Publications

Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians.

Muller YL, Saporito M, Day S, Bandesh K, Koroglu C, Kobes S, Knowler WC, Hanson RL, Regeneron Genetics Center, Van Hout CV, Shuldiner AR, Bogardus C, Baier LJ.

Eur J Hum Genet (2022 Oct) 30:1159-1166. Abstract/Full Text

A missense variant Arg611Cys in LIPE which encodes hormone sensitive lipase decreases lipolysis and increases risk of type 2 diabetes in American Indians.

Muller YL, Sutherland J, Nair AK, Koroglu C, Kobes S, Knowler WC, Van Hout CV, Regeneron Genetics Center, Shuldiner AR, Hanson RL, Bogardus C, Baier LJ.

Diabetes Metab Res Rev (2022 Mar) 38:e3504. Abstract/Full Text

Functional variants in cytochrome b5 type A (CYB5A) are enriched in Southwest American Indian individuals and associate with obesity.

Day SE, Traurig M, Kumar P, Piaggi P, Koroglu C, Kobes S, Hanson RL, Bogardus C, Baier LJ.

Obesity (Silver Spring) (2022 Feb) 30:546-552. Abstract/Full Text

Relationship Between Insulin Secretion and Insulin Sensitivity and its Role in Development of Type 2 Diabetes Mellitus: Beyond the Disposition Index.

Vazquez Arreola E, Hanson RL, Bogardus C, Knowler WC.

Diabetes (2021 Oct 18) Abstract/Full Text

Erratum. Impaired Metabolic Flexibility to High-Fat Overfeeding Predicts Future Weight Gain in Healthy Adults. Diabetes 2020;69:181-192.

Begaye B, Vinales KL, Hollstein T, Ando T, Walter M, Bogardus C, Krakoff J, Piaggi P.

Diabetes (2021 Apr) 70:1019. Abstract/Full Text

Exome Sequencing of 21 Bardet-Biedl Syndrome (BBS) Genes to Identify Obesity Variants in 6,851 American Indians.

Day SE, Muller YL, Koroglu C, Kobes S, Wiedrich K, Mahkee D, Kim HI, Van Hout C, Gosalia N, Ye B, Regeneron Genetics Center, Shuldiner AR, Knowler WC, Hanson RL, Bogardus C, Baier LJ.

Obesity (Silver Spring) (2021 Apr) 29:748-754. Abstract/Full Text

A Genome-Wide Association Study Using a Custom Genotyping Array Identifies Variants in GPR158 Associated With Reduced Energy Expenditure in American Indians.

Piaggi P, Masindova I, Muller YL, Mercader J, Wiessner GB, Chen P, SIGMA Type 2 Diabetes Consortium, Kobes S, Hsueh WC, Mongalo M, Knowler WC, Krakoff J, Hanson RL, Bogardus C, Baier LJ.

Diabetes (2017 Aug) 66:2284-2295. Abstract/Full Text

T-cell receptor repertoire variation may be associated with type 2 diabetes mellitus in humans.

Frankl JA, Thearle MS, Desmarais C, Bogardus C, Krakoff J.

Diabetes Metab Res Rev (2016 Mar) 32:297-307. Abstract/Full Text

Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians.

Nair AK, Piaggi P, McLean NA, Kaur M, Kobes S, Knowler WC, Bogardus C, Hanson RL, Baier LJ.

Diabetologia (2016 Mar) 59:481-91. Abstract/Full Text

Use of a High-Density Protein Microarray to Identify Autoantibodies in Subjects with Type 2 Diabetes Mellitus and an HLA Background Associated with Reduced Insulin Secretion.

Chang DC, Piaggi P, Hanson RL, Knowler WC, Bucci J, Thio G, Hohenadel MG, Bogardus C, Krakoff J.

PLoS One (2015) 10:e0143551. Abstract/Full Text

A Human Thrifty Phenotype Associated With Less Weight Loss During Caloric Restriction.

Reinhardt M, Thearle MS, Ibrahim M, Hohenadel MG, Bogardus C, Krakoff J, Votruba SB.

Diabetes (2015 Aug) 64:2859-67. Abstract/Full Text

Salsalate has no effect on insulin secretion but decreases insulin clearance: a randomized, placebo-controlled trial in subjects without diabetes.

Penesova A, Koska J, Ortega E, Bunt JC, Bogardus C, de Courten B.

Diabetes Obes Metab (2015 Jun) 17:608-612. Abstract/Full Text

A cis-eQTL in PFKFB2 is associated with diabetic nephropathy, adiposity and insulin secretion in American Indians.

Muller YL, Piaggi P, Hanson RL, Kobes S, Bhutta S, Abdussamad M, Leak-Johnson T, Kretzler M, Huang K, Weil EJ, Nelson RG, Knowler WC, Bogardus C, Baier LJ.

Hum Mol Genet (2015 May 15) 24:2985-96. Abstract/Full Text

Fasting hyperglycemia predicts lower rates of weight gain by increased energy expenditure and fat oxidation rate.

Piaggi P, Thearle MS, Bogardus C, Krakoff J.

J Clin Endocrinol Metab (2015 Mar) 100:1078-87. Abstract/Full Text

Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.

Muller YL, Thearle MS, Piaggi P, Hanson RL, Hoffman D, Gene B, Mahkee D, Huang K, Kobes S, Votruba S, Knowler WC, Bogardus C, Baier LJ.

Hum Genet (2014 Nov) 133:1431-41. Abstract/Full Text

Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure.

Muller YL, Piaggi P, Hoffman D, Huang K, Gene B, Kobes S, Thearle MS, Knowler WC, Hanson RL, Baier LJ, Bogardus C.

Diabetologia (2014 Jul) 57:1382-90. Abstract/Full Text

Potential epigenetic dysregulation of genes associated with MODY and type 2 diabetes in humans exposed to a diabetic intrauterine environment: an analysis of genome-wide DNA methylation.

del Rosario MC, Ossowski V, Knowler WC, Bogardus C, Baier LJ, Hanson RL.

Metabolism (2014 May) 63:654-60. Abstract/Full Text

Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes.

Huang K, Nair AK, Muller YL, Piaggi P, Bian L, Del Rosario M, Knowler WC, Kobes S, Hanson RL, Bogardus C, Baier LJ.

Obesity (Silver Spring) (2014 Apr) 22:984-8. Abstract/Full Text

A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes.

Hanson RL, Muller YL, Kobes S, Guo T, Bian L, Ossowski V, Wiedrich K, Sutherland J, Wiedrich C, Mahkee D, Huang K, Abdussamad M, Traurig M, Weil EJ, Nelson RG, Bennett PH, Knowler WC, Bogardus C, Baier LJ.

Diabetes (2014 Jan) 63:369-76. Abstract/Full Text

Lower "awake and fed thermogenesis" predicts future weight gain in subjects with abdominal adiposity.

Piaggi P, Krakoff J, Bogardus C, Thearle MS.

Diabetes (2013 Dec) 62:4043-51. Abstract/Full Text

MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation.

Bian L, Traurig M, Hanson RL, Marinelarena A, Kobes S, Muller YL, Malhotra A, Huang K, Perez J, Gale A, Knowler WC, Bogardus C, Baier LJ.

Hum Mol Genet (2013 Nov 1) 22:4438-49. Abstract/Full Text

Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes.

Muller YL, Hanson RL, Knowler WC, Fleming J, Goswami J, Huang K, Traurig M, Sutherland J, Wiedrich C, Wiedrich K, Mahkee D, Ossowski V, Kobes S, Bogardus C, Baier LJ.

Hum Genet (2013 Jun) 132:697-707. Abstract/Full Text

Lower energy expenditure predicts long-term increases in weight and fat mass.

Piaggi P, Thearle MS, Bogardus C, Krakoff J.

J Clin Endocrinol Metab (2013 Apr) 98:E703-7. Abstract/Full Text

Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans.

Traurig MT, Orczewska JI, Ortiz DJ, Bian L, Marinelarena AM, Kobes S, Malhotra A, Hanson RL, Mason CC, Knowler WC, Bogardus C, Baier LJ.

Obesity (Silver Spring) (2013 Jan) 21:193-202. Abstract/Full Text

Variants in the LEPR gene are nominally associated with higher BMI and lower 24-h energy expenditure in Pima Indians.

Traurig MT, Perez JM, Ma L, Bian L, Kobes S, Hanson RL, Knowler WC, Krakoff JA, Bogardus C, Baier LJ.

Obesity (Silver Spring) (2012 Dec) 20:2426-30. Abstract/Full Text

Association analyses of variants in the DIO2 gene with early-onset type 2 diabetes mellitus in Pima Indians.

Nair S, Muller YL, Ortega E, Kobes S, Bogardus C, Baier LJ.

Thyroid (2012 Jan) 22:80-7. Abstract/Full Text

SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians.

Dong Y, Guo T, Traurig M, Mason CC, Kobes S, Perez J, Knowler WC, Bogardus C, Hanson RL, Baier LJ.

Mol Genet Metab (2011 Dec) 104:661-5. Abstract/Full Text

HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion.

Williams RC, Muller YL, Hanson RL, Knowler WC, Mason CC, Bian L, Ossowski V, Wiedrich K, Chen YF, Marcovina S, Hahnke J, Nelson RG, Baier LJ, Bogardus C.

Diabetologia (2011 Jul) 54:1684-92. Abstract/Full Text

Effect of paternal diabetes on pre-diabetic phenotypes in adult offspring.

Penesova A, Bunt JC, Bogardus C, Krakoff J.

Diabetes Care (2010 Aug) 33:1823-8. Abstract/Full Text

Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians.

Bian L, Hanson RL, Muller YL, Ma L, MAGIC Investigators, Kobes S, Knowler WC, Bogardus C, Baier LJ.

Diabetologia (2010 Jul) 53:1349-53. Abstract/Full Text

Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians.

Bian L, Hanson RL, Ossowski V, Wiedrich K, Mason CC, Traurig M, Muller YL, Kobes S, Knowler WC, Baier LJ, Bogardus C.

Diabetes (2010 May) 59:1276-82. Abstract/Full Text

Common variation in SIM1 is reproducibly associated with BMI in Pima Indians.

Traurig M, Mack J, Hanson RL, Ghoussaini M, Meyre D, Knowler WC, Kobes S, Froguel P, Bogardus C, Baier LJ.

Diabetes (2009 Jul) 58:1682-9. Abstract/Full Text

Glucose allostasis: disrobing common wisdom.

Stumvoll M, Bogardus C.

Diabetologia (2009 May) 52:779-80. Abstract/Full Text

Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.

Rong R, Hanson RL, Ortiz D, Wiedrich C, Kobes S, Knowler WC, Bogardus C, Baier LJ.

Diabetes (2009 Feb) 58:478-88. Abstract/Full Text

Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant.

Krakoff J, Ma L, Kobes S, Knowler WC, Hanson RL, Bogardus C, Baier LJ.

Diabetes (2008 Dec) 57:3267-72. Abstract/Full Text

Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals.

Koska J, Stefan N, Permana PA, Weyer C, Sonoda M, Bogardus C, Smith SR, Joanisse DR, Funahashi T, Krakoff J, Bunt JC.

Am J Clin Nutr (2008 Feb) 87:295-302. Abstract/Full Text

Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations.

Bunt JC, Krakoff J, Ortega E, Knowler WC, Bogardus C.

Diabetes Metab Res Rev (2007 May) 23:304-10. Abstract/Full Text

Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons.

Ortega E, Pannacciulli N, Bogardus C, Krakoff J.

Am J Clin Nutr (2007 Feb) 85:440-5. Abstract/Full Text