Carson C. Chow, Ph.D.

Section Chief: Mathematical Biology Section, Laboratory of Biological Modeling

Scientific Focus Areas: Computational Biology, Genetics and Genomics, Molecular Biology and Biochemistry, Neuroscience, Systems Biology

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Publications

A selection of recent and significant publications can be viewed below.

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Distributing task-related neural activity across a cortical network through task-independent connections.: Kim CM, Finkelstein A, Chow CC, Svoboda K, Darshan R.; Nat Commun (2023 May 18) 14:2851. Abstract/Full Text
Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila.: Elliott AD, Berndt A, Houpert M, Roy S, Scott RL, Chow CC, Shroff H, White BH.; Elife (2021 Jul 8) 10. Abstract/Full Text
Dynamic imaging of nascent RNA reveals general principles of transcription dynamics and stochastic splice site selection.: Wan Y, Anastasakis DG, Rodriguez J, Palangat M, Gudla P, Zaki G, Tandon M, Pegoraro G, Chow CC, Hafner M, Larson DR.; Cell (2021 May 27) 184:2878-2895.e20. Abstract/Full Text
Divergent COVID-19 Disease Trajectories Predicted by a DAMP-Centered Immune Network Model.: Day JD, Park S, Ranard BL, Singh H, Chow CC, Vodovotz Y.; Front Immunol (2021) 12:754127. Abstract/Full Text
Intrinsic Dynamics of a Human Gene Reveal the Basis of Expression Heterogeneity.: Rodriguez J, Ren G, Day CR, Zhao K, Chow CC, Larson DR.; Cell (2019 Jan 10) 176:213-226.e18. Abstract/Full Text

Additional Publications

An Approach to Greater Specificity for Glucocorticoids.: Chow CC, Simons SS Jr.; Front Endocrinol (Lausanne) (2018) 9:76. Abstract/Full Text
Impact of Masked Replacement of Sugar-Sweetened with Sugar-Free Beverages on Body Weight Increases with Initial BMI: Secondary Analysis of Data from an 18 Month Double-Blind Trial in Children.: Katan MB, de Ruyter JC, Kuijper LD, Chow CC, Hall KD, Olthof MR.; PLoS One (2016) 11:e0159771. Abstract/Full Text
Modeling glucose and free fatty acid kinetics in glucose and meal tolerance test.: Li Y, Chow CC, Courville AB, Sumner AE, Periwal V.; Theor Biol Med Model (2016 Mar 2) 13:8. Abstract/Full Text
Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction.: Pradhan MA, Blackford JA Jr, Devaiah BN, Thompson PS, Chow CC, Singer DS, Simons SS Jr.; J Biol Chem (2016 Jan 1) 291:342-54. Abstract/Full Text
Uncovering the Genetic Architectures of Quantitative Traits.: Lee JJ, Vattikuti S, Chow CC.; Comput Struct Biotechnol J (2016) 14:28-34. Abstract/Full Text
Increased food energy supply as a major driver of the obesity epidemic: a global analysis.: Vandevijvere S, Chow CC, Hall KD, Umali E, Swinburn BA.; Bull World Health Organ (2015 Jul 1) 93:446-56. Abstract/Full Text
Dynamics of chromatin accessibility and long-range interactions in response to glucocorticoid pulsing.: Stavreva DA, Coulon A, Baek S, Sung MH, John S, Stixova L, Tesikova M, Hakim O, Miranda T, Hawkins M, Stamatoyannopoulos JA, Chow CC, Hager GL.; Genome Res (2015 Jun) 25:845-57. Abstract/Full Text
Path integral methods for stochastic differential equations.: Chow CC, Buice MA.; J Math Neurosci (2015) 5:8. Abstract/Full Text
Second-generation PLINK: rising to the challenge of larger and richer datasets.: Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ.; Gigascience (2015) 4:7. Abstract/Full Text
Kinetic competition during the transcription cycle results in stochastic RNA processing.: Coulon A, Ferguson ML, de Turris V, Palangat M, Chow CC, Larson DR.; Elife (2014 Oct 1) 3. Abstract/Full Text
Conditions for the validity of SNP-based heritability estimation.: Lee JJ, Chow CC.; Hum Genet (2014 Aug) 133:1011-22. Abstract/Full Text
Short and long-term energy intake patterns and their implications for human body weight regulation.: Chow CC, Hall KD.; Physiol Behav (2014 Jul) 134:60-5. Abstract/Full Text
Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay.: Blackford JA Jr, Brimacombe KR, Dougherty EJ, Pradhan M, Shen M, Li Z, Auld DS, Chow CC, Austin CP, Simons SS Jr.; Mol Endocrinol (2014 Jul) 28:1194-206. Abstract/Full Text
A kinase-independent activity of Cdk9 modulates glucocorticoid receptor-mediated gene induction.: Zhu R, Lu X, Pradhan M, Armstrong SP, Storchan GB, Chow CC, Simons SS Jr.; Biochemistry (2014 Mar 25) 53:1753-67. Abstract/Full Text
Why is the 3500 kcal per pound weight loss rule wrong?: Hall KD, Chow CC.; Int J Obes (Lond) (2013 Dec) 37:1614. Abstract/Full Text
A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties.: Luo M, Lu X, Zhu R, Zhang Z, Chow CC, Li R, Simons SS Jr.; J Biol Chem (2013 Nov 22) 288:34055-34072. Abstract/Full Text
Generalized activity equations for spiking neural network dynamics.: Buice MA, Chow CC.; Front Comput Neurosci (2013) 7:162. Abstract/Full Text
Dynamics of childhood growth and obesity: development and validation of a quantitative mathematical model.: Hall KD, Butte NF, Swinburn BA, Chow CC.; Lancet Diabetes Endocrinol (2013 Oct) 1:97-105. Abstract/Full Text
Eukaryotic transcriptional dynamics: from single molecules to cell populations.: Coulon A, Chow CC, Singer RH, Larson DR.; Nat Rev Genet (2013 Aug) 14:572-84. Abstract/Full Text
A new method for determining gastric acid output using a wireless pH-sensing capsule.: Weinstein DH, deRijke S, Chow CC, Foruraghi L, Zhao X, Wright EC, Whatley M, Maass-Moreno R, Chen CC, Wank SA.; Aliment Pharmacol Ther (2013 Jun) 37:1198-209. Abstract/Full Text
The causal meaning of Fisher's average effect.: Lee JJ, Chow CC.; Genet Res (Camb) (2013 Jun) 95:89-109. Abstract/Full Text
Sex-associated differences in free fatty acid flux of obese adolescents.: Adler-Wailes DC, Periwal V, Ali AH, Brady SM, McDuffie JR, Uwaifo GI, Tanofsky-Kraff M, Salaita CG, Hubbard VS, Reynolds JC, Chow CC, Sumner AE, Yanovski JA.; J Clin Endocrinol Metab (2013 Apr) 98:1676-84. Abstract/Full Text
Beyond mean field theory: statistical field theory for neural networks.: Buice MA, Chow CC.; J Stat Mech (2013 Mar) 2013:P03003. Abstract/Full Text
PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation.: Zhang Z, Sun Y, Cho YW, Chow CC, Simons SS Jr.; J Biol Chem (2013 Jan 4) 288:42-58. Abstract/Full Text
Dynamic finite size effects in spiking neural networks.: Buice MA, Chow CC.; PLoS Comput Biol (2013) 9:e1002872. Abstract/Full Text
Bayesian functional integral method for inferring continuous data from discrete measurements.: Heuett WJ, Miller BV 3rd, Racette SB, Holloszy JO, Chow CC, Periwal V.; Biophys J (2012 Feb 8) 102:399-406. Abstract/Full Text
The road less traveled: new views of steroid receptor action from the path of dose-response curves.: Simons SS Jr, Chow CC.; Mol Cell Endocrinol (2012 Jan 30) 348:373-82. Abstract/Full Text
Deducing the temporal order of cofactor function in ligand-regulated gene transcription: theory and experimental verification.: Dougherty EJ, Guo C, Simons SS Jr, Chow CC.; PLoS One (2012) 7:e30225. Abstract/Full Text
Heritability and genetic correlations explained by common SNPs for metabolic syndrome traits.: Vattikuti S, Guo J, Chow CC.; PLoS Genet (2012) 8:e1002637. Abstract/Full Text
Repetition priming and repetition suppression: Multiple mechanisms in need of testing.: Gotts SJ, Chow CC, Martin A.; Cogn Neurosci (2012) 3:250-9. Abstract/Full Text
Role of mutual inhibition in binocular rivalry.: Seely J, Chow CC.; J Neurophysiol (2011 Nov) 106:2136-50. Abstract/Full Text
Effective stochastic behavior in dynamical systems with incomplete information.: Buice MA, Chow CC.; Phys Rev E Stat Nonlin Soft Matter Phys (2011 Nov) 84:051120. Abstract/Full Text
Quantification of the effect of energy imbalance on bodyweight.: Hall KD, Sacks G, Chandramohan D, Chow CC, Wang YC, Gortmaker SL, Swinburn BA.; Lancet (2011 Aug 27) 378:826-37. Abstract/Full Text
Higher acute insulin response to glucose may determine greater free fatty acid clearance in African-American women.: Chow CC, Periwal V, Csako G, Ricks M, Courville AB, Miller BV 3rd, Vega GL, Sumner AE.; J Clin Endocrinol Metab (2011 Aug) 96:2456-63. Abstract/Full Text
Estimating changes in free-living energy intake and its confidence interval.: Hall KD, Chow CC.; Am J Clin Nutr (2011 Jul) 94:66-74. Abstract/Full Text
Inferring mechanisms from dose-response curves.: Chow CC, Ong KM, Dougherty EJ, Simons SS Jr.; Methods Enzymol (2011) 487:465-83. Abstract/Full Text
Molecular evolution of the transmembrane domains of G protein-coupled receptors.: Fatakia SN, Costanzi S, Chow CC.; PLoS One (2011) 6:e27813. Abstract/Full Text
A theoretical framework for gene induction and experimental comparisons.: Ong KM, Blackford JA Jr, Kagan BL, Simons SS Jr, Chow CC.; Proc Natl Acad Sci U S A (2010 Apr 13) 107:7107-12. Abstract/Full Text
A computational model for cerebral cortical dysfunction in autism spectrum disorders.: Vattikuti S, Chow CC.; Biol Psychiatry (2010 Apr 1) 67:672-8. Abstract/Full Text
Estimating the quantitative relation between food energy intake and changes in body weight.: Hall KD, Chow CC.; Am J Clin Nutr (2010 Mar) 91:816; author reply 817. Abstract/Full Text
Systematic fluctuation expansion for neural network activity equations.: Buice MA, Cowan JD, Chow CC.; Neural Comput (2010 Feb) 22:377-426. Abstract/Full Text
The progressive increase of food waste in America and its environmental impact.: Hall KD, Guo J, Dore M, Chow CC.; PLoS One (2009 Nov 25) 4:e7940. Abstract/Full Text
The dynamics of human body weight change.: Chow CC, Hall KD.; PLoS Comput Biol (2008 Mar 28) 4:e1000045. Abstract/Full Text
Kinetic theory of coupled oscillators.: Hildebrand EJ, Buice MA, Chow CC.; Phys Rev Lett (2007 Feb 2) 98:054101. Abstract/Full Text

Last Reviewed February 2024