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Irina V. Gopich, Ph.D.

Photo of Irina Gopich
Staff Scientist: Theoretical Biophysical Chemistry Section, Laboratory of Chemical Physics
Scientific Focus Areas: Biomedical Engineering and Biophysics, Computational Biology
301-496-1880 Add to Contacts

Publications

A selection of recent and significant publications can be viewed below.

Oligomerization of the tetramerization domain of p53 probed by two- and three-color single-molecule FRET.
Chung HS, Meng F, Kim JY, McHale K, Gopich IV, Louis JM.
Proc Natl Acad Sci U S A (2017 Aug 15) 114:E6812-E6821. Abstract/Full Text
Reversible Stochastically Gated Diffusion-Influenced Reactions.
Gopich IV, Szabo A.
J Phys Chem B (2016 Aug 25) 120:8080-9. Abstract/Full Text
Analysis of Fluorescence Lifetime and Energy Transfer Efficiency in Single-Molecule Photon Trajectories of Fast-Folding Proteins.
Chung HS, Louis JM, Gopich IV.
J Phys Chem B (2016 Feb 4) 120:680-99. Abstract/Full Text
Influence of diffusion on the kinetics of multisite phosphorylation.
Gopich IV, Szabo A.
Protein Sci (2016 Jan) 25:244-54. Abstract/Full Text
Accuracy of maximum likelihood estimates of a two-state model in single-molecule FRET.
Gopich IV.
J Chem Phys (2015 Jan 21) 142:034110. Abstract/Full Text
Fast single-molecule FRET spectroscopy: theory and experiment.
Chung HS, Gopich IV.
Phys Chem Chem Phys (2014 Sep 21) 16:18644-57. Abstract/Full Text
Diffusion modifies the connectivity of kinetic schemes for multisite binding and catalysis.
Gopich IV, Szabo A.
Proc Natl Acad Sci U S A (2013 Dec 3) 110:19784-9. Abstract/Full Text
Theory of the energy transfer efficiency and fluorescence lifetime distribution in single-molecule FRET.
Gopich IV, Szabo A.
Proc Natl Acad Sci U S A (2012 May 15) 109:7747-52. Abstract/Full Text
Likelihood functions for the analysis of single-molecule binned photon sequences.
Gopich IV.
Chem Phys (2012 Mar 2) 396:53-60. Abstract/Full Text
Extracting rate coefficients from single-molecule photon trajectories and FRET efficiency histograms for a fast-folding protein.
Chung HS, Gopich IV, McHale K, Cellmer T, Louis JM, Eaton WA.
J Phys Chem A (2011 Apr 28) 115:3642-56. Abstract/Full Text
FRET efficiency distributions of multistate single molecules.
Gopich IV, Szabo A.
J Phys Chem B (2010 Nov 25) 114:15221-6. Abstract/Full Text
Protein dynamics from single-molecule fluorescence intensity correlation functions.
Gopich IV, Nettels D, Schuler B, Szabo A.
J Chem Phys (2009 Sep 7) 131:095102. Abstract/Full Text
Decoding the pattern of photon colors in single-molecule FRET.
Gopich IV, Szabo A.
J Phys Chem B (2009 Aug 6) 113:10965-73. Abstract/Full Text
Concentration effects in "single-molecule" spectroscopy.
Gopich IV.
J Phys Chem B (2008 May 15) 112:6214-20. Abstract/Full Text
Effect of flexibility and cis residues in single-molecule FRET studies of polyproline.
Best RB, Merchant KA, Gopich IV, Schuler B, Bax A, Eaton WA.
Proc Natl Acad Sci U S A (2007 Nov 27) 104:18964-9. Abstract/Full Text
Single-molecule FRET with diffusion and conformational dynamics.
Gopich IV, Szabo A.
J Phys Chem B (2007 Nov 8) 111:12925-32. Abstract/Full Text
Ultrafast dynamics of protein collapse from single-molecule photon statistics.
Nettels D, Gopich IV, Hoffmann A, Schuler B.
Proc Natl Acad Sci U S A (2007 Feb 20) 104:2655-60. Abstract/Full Text
Characterizing the unfolded states of proteins using single-molecule FRET spectroscopy and molecular simulations.
Merchant KA, Best RB, Louis JM, Gopich IV, Eaton WA.
Proc Natl Acad Sci U S A (2007 Jan 30) 104:1528-33. Abstract/Full Text
When does the Michaelis-Menten equation hold for fluctuating enzymes?
Min W, Gopich IV, English BP, Kou SC, Xie XS, Szabo A.
J Phys Chem B (2006 Oct 19) 110:20093-7. Abstract/Full Text
Theory of the statistics of kinetic transitions with application to single-molecule enzyme catalysis.
Gopich IV, Szabo A.
J Chem Phys (2006 Apr 21) 124:154712. Abstract/Full Text
Photon counting histograms for diffusing fluorophores.
Gopich IV, Szabo A.
J Phys Chem B (2005 Sep 22) 109:17683-8. Abstract/Full Text
Fluorophore-quencher distance correlation functions from single-molecule photon arrival trajectories.
Gopich I, Szabo A.
J Phys Chem B (2005 Apr 14) 109:6845-8. Abstract/Full Text
Theory of photon statistics in single-molecule Förster resonance energy transfer.
Gopich I, Szabo A.
J Chem Phys (2005 Jan 1) 122:14707. Abstract/Full Text
Influence of diffusion on the kinetics of excited-state association--dissociation reactions: comparison of theory and simulation.
Popov AV, Agmon N, Gopich IV, Szabo A.
J Chem Phys (2004 Apr 1) 120:6111-6. Abstract/Full Text
Long-time tails in the kinetics of reversible bimolecular reactions.
Gopich IV, Ovchinnikov AA, Szabo A.
Phys Rev Lett (2001 Jan 29) 86:922-5. Abstract/Full Text

Books and Book Chapters

"Theory of single-molecule FRET efficiency histograms."
Gopich IV, Szabo A.
Single Molecule Biophysics: Experiments and Theories.
Adv. Chem. Phys. (2012) Volume 146, Part 2:245-298.
"Theory of photon counting in single-molecule spectroscopy."
Gopich IV, Szabo A.
Theory and Evaluation of Single-Molecule Signals.
Barkai E, Brown FLH, Orrit M, eds.
World Scientific. (2008) 181–244.