Daniel C. Masison, Ph.D.

Scientific Focus Areas: Cell Biology, Genetics and Genomics, Molecular Biology and Biochemistry
Publications
A selection of recent and significant publications can be viewed below.
Select Publications
- Prokaryotic chaperones support yeast prions and thermotolerance and define disaggregation machinery interactions.
- Reidy M, Miot M, Masison DC.
- Genetics (2012 Sep) 192:185-93. Abstract/Full Text
- Single methyl group determines prion propagation and protein degradation activities of yeast heat shock protein (Hsp)-70 chaperones Ssa1p and Ssa2p.
- Sharma D, Masison DC.
- Proc Natl Acad Sci U S A (2011 Aug 16) 108:13665-70. Abstract/Full Text
- Dual Roles for Yeast Sti1/Hop in Regulating the Hsp90 Chaperone Cycle.
- Reidy M, Kumar S, Anderson DE, Masison DC.
- Genetics (2018 Aug) 209:1139-1154. Abstract/Full Text
- Human J-protein DnaJB6b Cures a Subset of Saccharomyces cerevisiae Prions and Selectively Blocks Assembly of Structurally Related Amyloids.
- Reidy M, Sharma R, Roberts BL, Masison DC.
- J Biol Chem (2016 Feb 19) 291:4035-47. Abstract/Full Text
- N-terminal domain of yeast Hsp104 chaperone is dispensable for thermotolerance and prion propagation but necessary for curing prions by Hsp104 overexpression.
- Hung GC, Masison DC.
- Genetics (2006 Jun) 173:611-20. Abstract/Full Text
Additional Publications
- Hsp40s specify functions of Hsp104 and Hsp90 protein chaperone machines.
- Reidy M, Sharma R, Shastry S, Roberts BL, Albino-Flores I, Wickner S, Masison DC.
- PLoS Genet (2014 Oct) 10:e1004720. Abstract/Full Text
- The BAG homology domain of Snl1 cures yeast prion [URE3] through regulation of Hsp70 chaperones.
- Kumar N, Gaur D, Masison DC, Sharma D.
- G3 (Bethesda) (2014 Mar 20) 4:461-70. Abstract/Full Text
- Schizosaccharomyces pombe disaggregation machinery chaperones support Saccharomyces cerevisiae growth and prion propagation.
- Reidy M, Sharma R, Masison DC.
- Eukaryot Cell (2013 May) 12:739-45. Abstract/Full Text
- Modulation and elimination of yeast prions by protein chaperones and co-chaperones.
- Reidy M, Masison DC.
- Prion (2011 Oct-Dec) 5:245-9. Abstract/Full Text
- Functions of yeast Hsp40 chaperone Sis1p dispensable for prion propagation but important for prion curing and protection from prion toxicity.
- Kirkland PA, Reidy M, Masison DC.
- Genetics (2011 Jul) 188:565-77. Abstract/Full Text
- Species-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation.
- Miot M, Reidy M, Doyle SM, Hoskins JR, Johnston DM, Genest O, Vitery MC, Masison DC, Wickner S.
- Proc Natl Acad Sci U S A (2011 Apr 26) 108:6915-20. Abstract/Full Text
- Sti1 regulation of Hsp70 and Hsp90 is critical for curing of Saccharomyces cerevisiae [PSI+] prions by Hsp104.
- Reidy M, Masison DC.
- Mol Cell Biol (2010 Jul) 30:3542-52. Abstract/Full Text
- Function of SSA subfamily of Hsp70 within and across species varies widely in complementing Saccharomyces cerevisiae cell growth and prion propagation.
- Sharma D, Martineau CN, Le Dall MT, Reidy M, Masison DC, Kabani M.
- PLoS One (2009 Aug 14) 4:e6644. Abstract/Full Text
- Influence of Hsp70s and their regulators on yeast prion propagation.
- Masison DC, Kirkland PA, Sharma D.
- Prion (2009 Apr-Jun) 3:65-73. Abstract/Full Text
- Curing of yeast [URE3] prion by the Hsp40 cochaperone Ydj1p is mediated by Hsp70.
- Sharma D, Stanley RF, Masison DC.
- Genetics (2009 Jan) 181:129-37. Abstract/Full Text
- Hsp70 structure, function, regulation and influence on yeast prions.
- Sharma D, Masison DC.
- Protein Pept Lett (2009) 16:571-81. Abstract/Full Text
- Prion-impairing mutations in Hsp70 chaperone Ssa1: effects on ATPase and chaperone activities.
- Needham PG, Masison DC.
- Arch Biochem Biophys (2008 Oct 15) 478:167-74. Abstract/Full Text
- Functionally redundant isoforms of a yeast Hsp70 chaperone subfamily have different antiprion effects.
- Sharma D, Masison DC.
- Genetics (2008 Jul) 179:1301-11. Abstract/Full Text
- Primate chaperones Hsc70 (constitutive) and Hsp70 (induced) differ functionally in supporting growth and prion propagation in Saccharomyces cerevisiae.
- Tutar Y, Song Y, Masison DC.
- Genetics (2006 Feb) 172:851-61. Abstract/Full Text
- Independent regulation of Hsp70 and Hsp90 chaperones by Hsp70/Hsp90-organizing protein Sti1 (Hop1).
- Song Y, Masison DC.
- J Biol Chem (2005 Oct 7) 280:34178-85. Abstract/Full Text
- Role for Hsp70 chaperone in Saccharomyces cerevisiae prion seed replication.
- Song Y, Wu YX, Jung G, Tutar Y, Eisenberg E, Greene LE, Masison DC.
- Eukaryot Cell (2005 Feb) 4:289-97. Abstract/Full Text
- Cell biology: designer prions.
- Masison DC.
- Nature (2004 May 6) 429:37-8. Abstract/Full Text
- Propagation of Saccharomyces cerevisiae [PSI+] prion is impaired by factors that regulate Hsp70 substrate binding.
- Jones G, Song Y, Chung S, Masison DC.
- Mol Cell Biol (2004 May) 24:3928-37. Abstract/Full Text
- Deletion of the Hsp70 chaperone gene SSB causes hypersensitivity to guanidine toxicity and curing of the [PSI+] prion by increasing guanidine uptake in yeast.
- Jones GW, Song Y, Masison DC.
- Mol Genet Genomics (2003 Jun) 269:304-11. Abstract/Full Text
- Saccharomyces cerevisiae Hsp70 mutations affect [PSI+] prion propagation and cell growth differently and implicate Hsp40 and tetratricopeptide repeat cochaperones in impairment of [PSI+].
- Jones GW, Masison DC.
- Genetics (2003 Feb) 163:495-506. Abstract/Full Text
- Amino acid residue 184 of yeast Hsp104 chaperone is critical for prion-curing by guanidine, prion propagation, and thermotolerance.
- Jung G, Jones G, Masison DC.
- Proc Natl Acad Sci U S A (2002 Jul 23) 99:9936-41. Abstract/Full Text
- Antagonistic interactions between yeast [PSI(+)] and [URE3] prions and curing of [URE3] by Hsp70 protein chaperone Ssa1p but not by Ssa2p.
- Schwimmer C, Masison DC.
- Mol Cell Biol (2002 Jun) 22:3590-8. Abstract/Full Text
- Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions.
- Jung G, Masison DC.
- Curr Microbiol (2001 Jul) 43:7-10. Abstract/Full Text
- A role for cytosolic hsp70 in yeast [PSI(+)] prion propagation and [PSI(+)] as a cellular stress.
- Jung G, Jones G, Wegrzyn RD, Masison DC.
- Genetics (2000 Oct) 156:559-70. Abstract/Full Text
- Expanding the prion model for the yeast [PSI+] element.
- Masison DC.
- Trends Microbiol (2000 Jan) 8:1-3. Abstract/Full Text