Lily Ng, Ph.D.
Scientific Focus Areas: Cell Biology, Developmental Biology, Molecular Biology and Biochemistry

Publications

A selection of recent and significant publications can be viewed below.

Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10).
Sharlin DS, Ng L, Verrey F, Visser TJ, Liu Y, Olszewski RT, Hoa M, Heuer H, Forrest D.
Sci Rep (2018 Mar 13) 8:4403. Abstract/Full Text
SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells.
Xu XL, Li Z, Liu A, Fan X, Hu DN, Qi DL, Chitty DW, Jia R, Qui J, Wang JQ, Sharaf J, Zou J, Weiss R, Huang H, Joseph WJ, Ng L, Rosen R, Shen B, Reid MW, Forrest D, Abramson DH, Singer S, Cobrinik D, Jhanwar SC.
Cancer Res (2017 Dec 15) 77:6838-6850. Abstract/Full Text
Deletion of the Thyroid Hormone-Activating Type 2 Deiodinase Rescues Cone Photoreceptor Degeneration but Not Deafness in Mice Lacking Type 3 Deiodinase.
Ng L, Liu H, St Germain DL, Hernandez A, Forrest D.
Endocrinology (2017 Jun 1) 158:1999-2010. Abstract/Full Text
Age-Related Hearing Loss and Degeneration of Cochlear Hair Cells in Mice Lacking Thyroid Hormone Receptor β1.
Ng L, Cordas E, Wu X, Vella KR, Hollenberg AN, Forrest D.
Endocrinology (2015 Oct) 156:3853-65. Abstract/Full Text
A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1.
Huang CC, Kraft C, Moy N, Ng L, Forrest D.
Endocrinology (2015 Jun) 156:2338-48. Abstract/Full Text
The timecourse of apoptotic cell death during postnatal remodeling of the mouse cochlea and its premature onset by triiodothyronine (T3).
Peeters RP, Ng L, Ma M, Forrest D.
Mol Cell Endocrinol (2015 May 15) 407:1-8. Abstract/Full Text
Feedback induction of a photoreceptor-specific isoform of retinoid-related orphan nuclear receptor β by the rod transcription factor NRL.
Fu Y, Liu H, Ng L, Kim JW, Hao H, Swaroop A, Forrest D.
J Biol Chem (2014 Nov 21) 289:32469-80. Abstract/Full Text
Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1.
Peeters RP, Hernandez A, Ng L, Ma M, Sharlin DS, Pandey M, Simonds WF, St Germain DL, Forrest D.
Endocrinology (2013 Jan) 154:550-61. Abstract/Full Text
An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons.
Liu H, Kim SY, Fu Y, Wu X, Ng L, Swaroop A, Forrest D.
Nat Commun (2013) 4:1813. Abstract/Full Text
Thyroid hormone receptors control developmental maturation of the middle ear and the size of the ossicular bones.
Cordas EA, Ng L, Hernandez A, Kaneshige M, Cheng SY, Forrest D.
Endocrinology (2012 Mar) 153:1548-60. Abstract/Full Text
Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.
Ng L, Lu A, Swaroop A, Sharlin DS, Swaroop A, Forrest D.
J Neurosci (2011 Aug 3) 31:11118-25. Abstract/Full Text
Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors.
Ng L, Lyubarsky A, Nikonov SS, Ma M, Srinivas M, Kefas B, St Germain DL, Hernandez A, Pugh EN Jr, Forrest D.
J Neurosci (2010 Mar 3) 30:3347-57. Abstract/Full Text
Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development.
Jia L, Oh EC, Ng L, Srinivas M, Brooks M, Swaroop A, Forrest D.
Proc Natl Acad Sci U S A (2009 Oct 13) 106:17534-9. Abstract/Full Text
Developmental expression of thyroid hormone receptor beta2 protein in cone photoreceptors in the mouse.
Ng L, Ma M, Curran T, Forrest D.
Neuroreport (2009 Apr 22) 20:627-31. Abstract/Full Text
A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function.
Ng L, Hernandez A, He W, Ren T, Srinivas M, Ma M, Galton VA, St Germain DL, Forrest D.
Endocrinology (2009 Apr) 150:1952-60. Abstract/Full Text
Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice.
Lu A, Ng L, Ma M, Kefas B, Davies TF, Hernandez A, Chan CC, Forrest D.
Endocrinology (2009 Mar) 150:1536-44. Abstract/Full Text
An intron control region differentially regulates expression of thyroid hormone receptor beta2 in the cochlea, pituitary, and cone photoreceptors.
Jones I, Ng L, Liu H, Forrest D.
Mol Endocrinol (2007 May) 21:1108-19. Abstract/Full Text
Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta.
Srinivas M, Ng L, Liu H, Jia L, Forrest D.
Mol Endocrinol (2006 Aug) 20:1728-41. Abstract/Full Text
Deafness in Claudin 11-null mice reveals the critical contribution of basal cell tight junctions to stria vascularis function.
Gow A, Davies C, Southwood CM, Frolenkov G, Chrustowski M, Ng L, Yamauchi D, Marcus DC, Kachar B.
J Neurosci (2004 Aug 11) 24:7051-62. Abstract/Full Text
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase.
Ng L, Goodyear RJ, Woods CA, Schneider MJ, Diamond E, Richardson GP, Kelley MW, Germain DL, Galton VA, Forrest D.
Proc Natl Acad Sci U S A (2004 Mar 9) 101:3474-9. Abstract/Full Text
An emilin family extracellular matrix protein identified in the cochlear basilar membrane.
Amma LL, Goodyear R, Faris JS, Jones I, Ng L, Richardson G, Forrest D.
Mol Cell Neurosci (2003 Jul) 23:460-72. Abstract/Full Text
Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice.
Marians RC, Ng L, Blair HC, Unger P, Graves PN, Davies TF.
Proc Natl Acad Sci U S A (2002 Nov 26) 99:15776-81. Abstract/Full Text
Targeted disruption of Slc19a2, the gene encoding the high-affinity thiamin transporter Thtr-1, causes diabetes mellitus, sensorineural deafness and megaloblastosis in mice.
Oishi K, Hofmann S, Diaz GA, Brown T, Manwani D, Ng L, Young R, Vlassara H, Ioannou YA, Forrest D, Gelb BD.
Hum Mol Genet (2002 Nov 1) 11:2951-60. Abstract/Full Text
Retardation of cochlear maturation and impaired hair cell function caused by deletion of all known thyroid hormone receptors.
Rusch A, Ng L, Goodyear R, Oliver D, Lisoukov I, Vennstrom B, Richardson G, Kelley MW, Forrest D.
J Neurosci (2001 Dec 15) 21:9792-800. Abstract/Full Text
Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor alpha gene.
Ng L, Rüsch A, Amma LL, Nordström K, Erway LC, Vennström B, Forrest D.
Hum Mol Genet (2001 Nov 1) 10:2701-8. Abstract/Full Text
Audiogenic seizure susceptibility in thyroid hormone receptor beta-deficient mice.
Ng L, Pedraza PE, Faris JS, Vennström B, Curran T, Morreale de Escobar G, Forrest D.
Neuroreport (2001 Aug 8) 12:2359-62. Abstract/Full Text
A thyroid hormone receptor that is required for the development of green cone photoreceptors.
Ng L, Hurley JB, Dierks B, Srinivas M, Saltó C, Vennström B, Reh TA, Forrest D.
Nat Genet (2001 Jan) 27:94-8. Abstract/Full Text
Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.
Göthe S, Wang Z, Ng L, Kindblom JM, Barros AC, Ohlsson C, Vennström B, Forrest D.
Genes Dev (1999 May 15) 13:1329-41. Abstract/Full Text
Thyroid hormone receptor beta is essential for development of auditory function.
Forrest D, Erway LC, Ng L, Altschuler R, Curran T.
Nat Genet (1996 Jul) 13:354-7. Abstract/Full Text
N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone.
Ng L, Forrest D, Haugen BR, Wood WM, Curran T.
Mol Endocrinol (1995 Sep) 9:1202-13. Abstract/Full Text
Targeted disruption of NMDA receptor 1 gene abolishes NMDA response and results in neonatal death.
Forrest D, Yuzaki M, Soares HD, Ng L, Luk DC, Sheng M, Stewart CL, Morgan JI, Connor JA, Curran T.
Neuron (1994 Aug) 13:325-38. Abstract/Full Text
Differential roles for Fos and Jun in DNA-binding: redox-dependent and independent functions.
Ng L, Forrest D, Curran T.
Nucleic Acids Res (1993 Dec 25) 21:5831-7. Abstract/Full Text
Interaction of DNA polymerase delta, proliferating cell nuclear antigen, and synthetic oligonucleotide template-primers. Analysis by polyacrylamide gel electrophoresis-band mobility shift assay.
Ng L, McConnell M, Tan CK, Downey KM, Fisher PA.
J Biol Chem (1993 Jun 25) 268:13571-6. Abstract/Full Text
Enzymologic mechanism of calf thymus DNA polymerase delta.
Ng L, Tan CK, Downey KM, Fisher PA.
J Biol Chem (1991 Jun 25) 266:11699-704. Abstract/Full Text
Drosophila proliferating cell nuclear antigen. Structural and functional homology with its mammalian counterpart.
Ng L, Prelich G, Anderson CW, Stillman B, Fisher PA.
J Biol Chem (1990 Jul 15) 265:11948-54. Abstract/Full Text
Recognition and binding of template-primers containing defined abasic sites by Drosophila DNA polymerase alpha holoenzyme.
Ng L, Weiss SJ, Fisher PA.
J Biol Chem (1989 Aug 5) 264:13018-23. Abstract/Full Text

Books and Book Chapters

Thyroid hormone and the mammalian auditory system.
Forrest D, Ng L.
Springer Handbook of Auditory Research, “Hormones and Hearing” (2016) 7: 163-189.
Making sense with thyroid hormone.
Forrest D, Kelley MW, Ng L.
Nature Reviews Endocrinology (2013) 9: 296-307.
Multigenic control of thyroid hormone functions in the nervous system.
Celi FS, Forrest D, Nunez J, Ng L.
Mol. Cell Endocrinol. (2008) 287: 1-12.
Developmental roles of the thyroid hormone receptor a and b genes.
Forrest D, Ng L.
Advances in Developmental Biology (2006) 16: 1-32.
Analysis of nuclear receptor function in the mouse auditory system.
Amma LL, Forrest D, Jones I, Kelley MW, Lanford PJ, Ng L.
Meths. Enzymology (2003) 364: 426-448.
The thyroid hormone receptor b gene: structure and functions in the brain and sensory systems.
Forrest D, Jones I, Ng L, Srinivas M.
Thyroid (2003) 13: 1057-1068.