Barbora Piknova, Ph.D.
Scientific Focus Areas: Biomedical Engineering and Biophysics, Cell Biology, Molecular Pharmacology, Chemical Biology, Molecular Biology and Biochemistry


A selection of recent and significant publications can be viewed below.

Nitrate and Nitrite Metabolism in Aging Rats: A Comparative Study.
Piknova B, Park JW, Thomas SM, Tunau-Spencer KJ, Schechter AN.
Nutrients (2023 May 26) 15. Abstract/Full Text
(15) N-labeled dietary nitrate supplementation increases human skeletal muscle nitrate concentration and improves muscle torque production.
Kadach S, Park JW, Stoyanov Z, Black MI, Vanhatalo A, Burnley M, Walter PJ, Cai H, Schechter AN, Piknova B, Jones AM.
Acta Physiol (Oxf) (2023 Mar) 237:e13924. Abstract/Full Text
Distribution of dietary nitrate and its metabolites in rat tissues after (15)N-labeled nitrate administration.
Park JW, Piknova B, Walter PJ, Cai H, Upanan S, Thomas SM, Tunau-Spencer KJ, Schechter AN.
Sci Rep (2023 Mar 1) 13:3499. Abstract/Full Text
Human skeletal muscle nitrate and nitrite in individuals with peripheral arterial disease: Effect of inorganic nitrate supplementation and exercise.
Piknova B, Woessner MN, de Zevallos JO, Kraus WE, VanBruggen MD, Schechter AN, Allen JD.
Physiol Rep (2022 Dec) 10:e15531. Abstract/Full Text
Dietary Inorganic Nitrate as an Ergogenic Aid: An Expert Consensus Derived via the Modified Delphi Technique.
Shannon OM, Allen JD, Bescos R, Burke L, Clifford T, Easton C, Gonzalez JT, Jones AM, Jonvik KL, Larsen FJ, Peeling P, Piknova B, Siervo M, Vanhatalo A, McGawley K, Porcelli S.
Sports Med (2022 Oct) 52:2537-2558. Abstract/Full Text
Time course of human skeletal muscle nitrate and nitrite concentration changes following dietary nitrate ingestion.
Kadach S, Piknova B, Black MI, Park JW, Wylie LJ, Stoyanov Z, Thomas SM, McMahon NF, Vanhatalo A, Schechter AN, Jones AM.
Nitric Oxide (2022 Apr 1) 121:1-10. Abstract/Full Text
Skeletal Muscle Nitrate as a Regulator of Systemic Nitric Oxide Homeostasis.
Piknova B, Schechter AN, Park JW, Vanhatalo A, Jones AM.
Exerc Sport Sci Rev (2022 Jan 1) 50:2-13. Abstract/Full Text
Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements.
Park JW, Thomas SM, Wylie LJ, Jones AM, Vanhatalo A, Schechter AN, Piknova B.
J Vis Exp (2021 Jul 29) Abstract/Full Text
Control of rat muscle nitrate levels after perturbation of steady state dietary nitrate intake.
Park JW, Thomas SM, Schechter AN, Piknova B.
Nitric Oxide (2021 May 1) 109-110:42-49. Abstract/Full Text
Dietary Nitrate and Nitric Oxide Metabolism: Mouth, Circulation, Skeletal Muscle, and Exercise Performance.
Jones AM, Vanhatalo A, Seals DR, Rossman MJ, Piknova B, Jonvik KL.
Med Sci Sports Exerc (2021 Feb 1) 53:280-294. Abstract/Full Text
Potential roles of nitrate and nitrite in nitric oxide metabolism in the eye.
Park JW, Piknova B, Jenkins A, Hellinga D, Parver LM, Schechter AN.
Sci Rep (2020 Aug 5) 10:13166. Abstract/Full Text
Nitrate uptake and metabolism in human skeletal muscle cell cultures.
Srihirun S, Park JW, Teng R, Sawaengdee W, Piknova B, Schechter AN.
Nitric Oxide (2020 Jan 1) 94:1-8. Abstract/Full Text
Human skeletal muscle nitrate store: influence of dietary nitrate supplementation and exercise.
Wylie LJ, Park JW, Vanhatalo A, Kadach S, Black MI, Stoyanov Z, Schechter AN, Jones AM, Piknova B.
J Physiol (2019 Dec) 597:5565-5576. Abstract/Full Text
Inhaled nebulized nitrite and nitrate therapy in a canine model of hypoxia-induced pulmonary hypertension.
Cortés-Puch I, Sun J, Schechter AN, Solomon SB, Park JW, Feng J, Gilliard C, Natanson C, Piknova B.
Nitric Oxide (2019 Oct 1) 91:1-14. Abstract/Full Text
Compensatory mechanisms in myoglobin deficient mice preserve NO homeostasis.
Park JW, Piknova B, Dey S, Noguchi CT, Schechter AN.
Nitric Oxide (2019 Sep 1) 90:10-14. Abstract/Full Text
Commentaries on Viewpoint: Managing the power grid: How myoglobin can regulate Po(2) and energy distribution in skeletal muscle.
Bock JM, Kruse NT, Donnelly C, Hirai DM, Craig JC, Colburn TD, Musch TI, Poole DC, Rosenberry R, Tian F, Liu H, Nelson MD, Piknova B, Willis WT, Zuo L, Zhou T, Riveros-Rivera A, Cristancho E, Gunga HC.
J Appl Physiol (1985) (2019 Mar 1) 126:791-794. Abstract/Full Text
Platelet-based Detection of Nitric Oxide in Blood by Measuring VASP Phosphorylation.
Srihirun S, Schechter AN, Piknova B.
J Vis Exp (2019 Jan 7) Abstract/Full Text
Effect of dietary nitrate levels on nitrate fluxes in rat skeletal muscle and liver.
Gilliard CN, Lam JK, Cassel KS, Park JW, Schechter AN, Piknova B.
Nitric Oxide (2018 May 1) 75:1-7. Abstract/Full Text
Phosphorylated vasodilator-stimulated phosphoprotein (P-VASPSer239) in platelets is increased by nitrite and partially deoxygenated erythrocytes.
Srihirun S, Piknova B, Sibmooh N, Schechter AN.
PLoS One (2018) 13:e0193747. Abstract/Full Text
Acid Test for Nitrite Pharmacology.
Piknova B, Schechter AN.
Hypertension (2017 Jan) 69:13-14. Abstract/Full Text
Measuring Nitrite and Nitrate, Metabolites in the Nitric Oxide Pathway, in Biological Materials using the Chemiluminescence Method.
Piknova B, Park JW, Cassel KS, Gilliard CN, Schechter AN.
J Vis Exp (2016 Dec 25) Abstract/Full Text
Nitrate as a source of nitrite and nitric oxide during exercise hyperemia in rat skeletal muscle.
Piknova B, Park JW, Kwan Jeff Lam K, Schechter AN.
Nitric Oxide (2016 May 1) 55-56:54-61. Abstract/Full Text
Construction of effective disposable biosensors for point of care testing of nitrite.
Monteiro T, Rodrigues PR, Gonçalves AL, Moura JJ, Jubete E, Añorga L, Piknova B, Schechter AN, Silveira CM, Almeida MG.
Talanta (2015 Sep 1) 142:246-51. Abstract/Full Text
Skeletal muscle as an endogenous nitrate reservoir.
Piknova B, Park JW, Swanson KM, Dey S, Noguchi CT, Schechter AN.
Nitric Oxide (2015 May 1) 47:10-16. Abstract/Full Text
Inhibitory effect of nitrite on coagulation processes demonstrated by thrombelastography.
Park JW, Piknova B, Nghiem K, Lozier JN, Schechter AN.
Nitric Oxide (2014 Aug 31) 40:45-51. Abstract/Full Text
A flow cytometric analysis of the inhibition of platelet reactivity due to nitrite reduction by deoxygenated erythrocytes.
Akrawinthawong K, Park JW, Piknova B, Sibmooh N, Fucharoen S, Schechter AN.
PLoS One (2014) 9:e92435. Abstract/Full Text
In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines.
Wang D, Piknova B, Solomon SB, Cortes-Puch I, Kern SJ, Sun J, Kanias T, Gladwin MT, Helms C, Kim-Shapiro DB, Schechter AN, Natanson C.
Transfusion (2013 Dec) 53:3149-63. Abstract/Full Text
Comments on 'vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway'.
Piknova B, Schechter AN.
Br J Clin Pharmacol (2013 Jun) 75:1541-2. Abstract/Full Text
Effect of storage on levels of nitric oxide metabolites in platelet preparations.
Park JW, Piknova B, Kurtz J, Seetharaman S, Wagner SJ, Schechter AN.
Transfusion (2013 Mar) 53:637-44. Abstract/Full Text
In reply.
Park JW, Piknova B, Schechter AN.
Transfusion (2013 Jan) 53:235. Abstract/Full Text
Effect of blood nitrite and nitrate levels on murine platelet function.
Park JW, Piknova B, Huang PL, Noguchi CT, Schechter AN.
PLoS One (2013) 8:e55699. Abstract/Full Text
Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin.
Solomon SB, Bellavia L, Sweeney D, Piknova B, Perlegas A, Helms CC, Ferreyra GA, Bruce King S, Raat NJ, Kern SJ, Sun J, McPhail LC, Schechter AN, Natanson C, Gladwin MT, Kim-Shapiro DB.
Free Radic Biol Med (2012 Dec 15) 53:2229-39. Abstract/Full Text
Effect of storage levels of nitric oxide derivatives in blood components.
Qazi MA, Rizzatti F, Piknova B, Sibmooh N, Stroncek DF, Schechter AN.
F1000Res (2012) 1:35. Abstract/Full Text
Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation.
Srihirun S, Sriwantana T, Unchern S, Kittikool D, Noulsri E, Pattanapanyasat K, Fucharoen S, Piknova B, Schechter AN, Sibmooh N.
PLoS One (2012) 7:e30380. Abstract/Full Text
Erythropoietin in brain development and beyond.
Alnaeeli M, Wang L, Piknova B, Rogers H, Li X, Noguchi CT.
Anat Res Int (2012) 2012:953264. Abstract/Full Text
The role of nitrite in neurovascular coupling.
Piknova B, Kocharyan A, Schechter AN, Silva AC.
Brain Res (2011 Aug 17) 1407:62-8. Abstract/Full Text
Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction.
Hanson MS, Piknova B, Keszler A, Diers AR, Wang X, Gladwin MT, Hillery CA, Hogg N.
Br J Haematol (2011 Aug) 154:502-11. Abstract/Full Text
Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells.
Beleslin-Čokić BB, Cokić VP, Wang L, Piknova B, Teng R, Schechter AN, Noguchi CT.
Cytokine (2011 May) 54:129-35. Abstract/Full Text
Acute erythropoietin cardioprotection is mediated by endothelial response.
Teng R, Calvert JW, Sibmooh N, Piknova B, Suzuki N, Sun J, Martinez K, Yamamoto M, Schechter AN, Lefer DJ, Noguchi CT.
Basic Res Cardiol (2011 May) 106:343-54. Abstract/Full Text
Measurement of nitrite in blood samples using the ferricyanide-based hemoglobin oxidation assay.
Piknova B, Schechter AN.
Methods Mol Biol (2011) 704:39-56. Abstract/Full Text
The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies.
Piknova B, Keszler A, Hogg N, Schechter AN.
Nitric Oxide (2009 Mar) 20:88-94. Abstract/Full Text
The reaction between nitrite and oxyhemoglobin: a mechanistic study.
Keszler A, Piknova B, Schechter AN, Hogg N.
J Biol Chem (2008 Apr 11) 283:9615-22. Abstract/Full Text
Oxidation of iron-nitrosyl-hemoglobin by dehydroascorbic acid releases nitric oxide to form nitrite in human erythrocytes.
Sibmooh N, Piknova B, Rizzatti F, Schechter AN.
Biochemistry (2008 Mar 4) 47:2989-96. Abstract/Full Text
Nitric oxide from nitrite reduction by hemoglobin in the plasma and erythrocytes.
Chen K, Piknova B, Pittman RN, Schechter AN, Popel AS.
Nitric Oxide (2008 Feb) 18:47-60. Abstract/Full Text
Electron paramagnetic resonance analysis of nitrosylhemoglobin in humans during NO inhalation.
Piknova B, Gladwin MT, Schechter AN, Hogg N.
J Biol Chem (2005 Dec 9) 280:40583-8. Abstract/Full Text
The collapse of monolayers containing pulmonary surfactant phospholipids is kinetically determined.
Yan W, Piknova B, Hall SB.
Biophys J (2005 Jul) 89:306-14. Abstract/Full Text
Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease.
Crawford JH, Chacko BK, Pruitt HM, Piknova B, Hogg N, Patel RP.
Blood (2004 Sep 1) 104:1375-82. Abstract/Full Text
Pulmonary surfactant: phase behavior and function.
Piknova B, Schram V, Hall SB.
Curr Opin Struct Biol (2002 Aug) 12:487-94. Abstract/Full Text
Discrepancy between phase behavior of lung surfactant phospholipids and the classical model of surfactant function.
Piknova B, Schief WR, Vogel V, Discher BM, Hall SB.
Biophys J (2001 Oct) 81:2172-80. Abstract/Full Text
Fluorescence quenching and electron spin resonance study of percolation in a two-phase lipid bilayer containing bacteriorhodopsin.
Piknová B, Marsh D, Thompson TE.
Biophys J (1997 Jun) 72:2660-8. Abstract/Full Text
Last Reviewed November 2023