Attila Szabo, Ph.D., NIH Distinguished Investigator

Photo of Dr. Attila Szabo
Scientific Focus Areas: Biomedical Engineering and Biophysics, Computational Biology


A selection of recent and significant publications can be viewed below.

Select Publications

Transition paths in single-molecule force spectroscopy.
Cossio P, Hummer G, Szabo A.
J Chem Phys (2018 Mar 28) 148:123309. Abstract/Full Text
Influence of diffusion on the kinetics of multisite phosphorylation.
Gopich IV, Szabo A.
Protein Sci (2016 Jan) 25:244-54. Abstract/Full Text
Theory of the energy transfer efficiency and fluorescence lifetime distribution in single-molecule FRET.
Gopich IV, Szabo A.
Proc Natl Acad Sci U S A (2012 May 15) 109:7747-52. Abstract/Full Text
On artifacts in single-molecule force spectroscopy.
Cossio P, Hummer G, Szabo A.
Proc Natl Acad Sci U S A (2015 Nov 17) 112:14248-53. Abstract/Full Text
Effect of ligand diffusion on occupancy fluctuations of cell-surface receptors.
Berezhkovskii AM, Szabo A.
J Chem Phys (2013 Sep 28) 139:121910. Abstract/Full Text

Additional Publications

Dynamics of the Orientational Factor in Fluorescence Resonance Energy Transfer.
Hummer G, Szabo A.
J Phys Chem B (2017 Apr 20) 121:3331-3339. Abstract/Full Text
Dependence of the Enzymatic Velocity on the Substrate Dissociation Rate.
Berezhkovskii AM, Szabo A, Rotbart T, Urbakh M, Kolomeisky AB.
J Phys Chem B (2017 Apr 20) 121:3437-3442. Abstract/Full Text
Reversible Stochastically Gated Diffusion-Influenced Reactions.
Gopich IV, Szabo A.
J Phys Chem B (2016 Aug 25) 120:8080-9. Abstract/Full Text
Kinetic Ductility and Force-Spike Resistance of Proteins from Single-Molecule Force Spectroscopy.
Cossio P, Hummer G, Szabo A.
Biophys J (2016 Aug 23) 111:832-840. Abstract/Full Text
Theory of Crowding Effects on Bimolecular Reaction Rates.
Berezhkovskii AM, Szabo A.
J Phys Chem B (2016 Jul 7) 120:5998-6002. Abstract/Full Text
Optimal Dimensionality Reduction of Multistate Kinetic and Markov-State Models.
Hummer G, Szabo A.
J Phys Chem B (2015 Jul 23) 119:9029-37. Abstract/Full Text
PARP inhibitor attenuated colony formation can be restored by MAP kinase inhibitors in different irradiated cancer cell lines.
Hocsak E, Cseh A, Szabo A, Bellyei S, Pozsgai E, Kalai T, Hideg K, Sumegi B, Boronkai A.
Int J Radiat Biol (2014 Dec) 90:1152-61. Abstract/Full Text
A population-based analysis of emergent versus elective paraesophageal hernia repair using the Nationwide Inpatient Sample.
Jassim H, Seligman JT, Frelich M, Goldblatt M, Kastenmeier A, Wallace J, Zhao HS, Szabo A, Gould JC.
Surg Endosc (2014 Dec) 28:3473-8. Abstract/Full Text
Multidimensional reaction rate theory with anisotropic diffusion.
Berezhkovskii AM, Szabo A, Greives N, Zhou HX.
J Chem Phys (2014 Nov 28) 141:204106. Abstract/Full Text
Adiposity distribution influences circulating adiponectin levels.
Guenther M, James R, Marks J, Zhao S, Szabo A, Kidambi S.
Transl Res (2014 Oct) 164:270-7. Abstract/Full Text
Prescription of opioid and nonopioid analgesics for dental care in emergency departments: Findings from the National Hospital Ambulatory Medical Care Survey.
Okunseri C, Okunseri E, Xiang Q, Thorpe JM, Szabo A.
J Public Health Dent (2014 Fall) 74:283-92. Abstract/Full Text
The antiviral immune response in human conventional dendritic cells is controlled by the mammalian target of rapamycin.
Fekete T, Pazmandi K, Szabo A, Bacsi A, Koncz G, Rajnavölgyi E.
J Leukoc Biol (2014 Oct) 96:579-89. Abstract/Full Text
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, Cyrus N, Brokowski CE, Eisenbarth SC, Phillips GM, Cline GW, Phillips AJ, Medzhitov R.
Nature (2014 Sep 25) 513:559-63. Abstract/Full Text
Enhanced survival from radiation pneumonitis by combined irradiation to the skin.
Gao F, Fish BL, Szabo A, Schock A, Narayanan J, Jacobs ER, Moulder JE, Lazarova Z, Medhora M.
Int J Radiat Biol (2014 Sep) 90:753-61. Abstract/Full Text
TLR ligands upregulate RIG-I expression in human plasmacytoid dendritic cells in a type I IFN-independent manner.
Szabo A, Magyarics Z, Pazmandi K, Gopcsa L, Rajnavolgyi E, Bacsi A.
Immunol Cell Biol (2014 Sep) 92:671-8. Abstract/Full Text
The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications.
Camer D, Yu Y, Szabo A, Huang XF.
Mol Nutr Food Res (2014 Aug) 58:1750-9. Abstract/Full Text
Recent developments in kidney transplantation in children.
Rusai K, Szabo AJ.
Curr Opin Organ Transplant (2014 Aug) 19:381-6. Abstract/Full Text
Cone structure in subjects with known genetic relative risk for AMD.
Land ME, Cooper RF, Young J, Berg E, Kitchner T, Xiang Q, Szabo A, Ivacic LC, Stepien KE, Page CD, Carroll J, Connor T Jr, Brilliant M.
Optom Vis Sci (2014 Aug) 91:939-49. Abstract/Full Text
Rap1b in smooth muscle and endothelium is required for maintenance of vascular tone and normal blood pressure.
Lakshmikanthan S, Zieba BJ, Ge ZD, Momotani K, Zheng X, Lund H, Artamonov MV, Maas JE, Szabo A, Zhang DX, Auchampach JA, Mattson DL, Somlyo AV, Chrzanowska-Wodnicka M.
Arterioscler Thromb Vasc Biol (2014 Jul) 34:1486-94. Abstract/Full Text
Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer.
Qi X, Xie C, Hou S, Li G, Yin N, Dong L, Lepp A, Chesnik MA, Mirza SP, Szabo A, Tsai S, Basir Z, Wu S, Chen G.
Oncotarget (2014 Jun 30) 5:4269-82. Abstract/Full Text
Mode of action of the positive modulator PNU-120596 on α7 nicotinic acetylcholine receptors.
Szabo AK, Pesti K, Mike A, Vizi ES.
Neuropharmacology (2014 Jun) 81:42-54. Abstract/Full Text
Kinetic properties and open probability of α7 nicotinic acetylcholine receptors.
Pesti K, Szabo AK, Mike A, Vizi ES.
Neuropharmacology (2014 Jun) 81:101-15. Abstract/Full Text
Peripheral CD4+ cell prevalence and pleuropulmonary manifestations in systemic lupus erythematosus patients.
Vincze K, Kovats Z, Cseh A, Pasti K, Kiss E, Polgar A, Vasarhelyi B, Szabo AJ, Bohacs A, Tamasi L, Losonczy G, Müller V.
Respir Med (2014 May) 108:766-74. Abstract/Full Text
Finding a fairy in the forest: ELF4, a novel and critical element of type I interferon responses.
Szabo A, Rajnavolgyi E.
Cell Mol Immunol (2014 May) 11:218-20. Abstract/Full Text
Cisplatin versus carboplatin-based regimens for the treatment of patients with metastatic lung cancer. An analysis of Veterans Health Administration data.
Santana-Davila R, Szabo A, Arce-Lara C, Williams CD, Kelley MJ, Whittle J.
J Thorac Oncol (2014 May) 9:702-9. Abstract/Full Text
Influence of allowable interruption period on estimates of accelerometer wear time and sedentary time in older adults.
Mailey EL, Gothe NP, Wójcicki TR, Szabo AN, Olson EA, Mullen SP, Fanning JT, Motl RW, McAuley E.
J Aging Phys Act (2014 Apr) 22:255-60. Abstract/Full Text
Peroxynitrite disrupts endothelial caveolae leading to eNOS uncoupling and diminished flow-mediated dilation in coronary arterioles of diabetic patients.
Cassuto J, Dou H, Czikora I, Szabo A, Patel VS, Kamath V, Belin de Chantemele E, Feher A, Romero MJ, Bagi Z.
Diabetes (2014 Apr) 63:1381-93. Abstract/Full Text
Exposure to neighborhood green space and mental health: evidence from the survey of the health of Wisconsin.
Beyer KM, Kaltenbach A, Szabo A, Bogar S, Nieto FJ, Malecki KM.
Int J Environ Res Public Health (2014 Mar 21) 11:3453-72. Abstract/Full Text
Marked differences of haplotype tagging SNP distribution, linkage, and haplotype profile of IL23 receptor gene in Roma and Hungarian population samples.
Magyari L, Varszegi D, Sarlos P, Jaromi L, Melegh BI, Duga B, Kisfali P, Kovesdi E, Matyas P, Szabo A, Szalai R, Melegh B.
Cytokine (2014 Feb) 65:148-52. Abstract/Full Text
PACAP promotes neuron survival in early experimental diabetic retinopathy.
Szabadfi K, Szabo A, Kiss P, Reglodi D, Setalo G Jr, Kovacs K, Tamas A, Toth G, Gabriel R.
Neurochem Int (2014 Jan) 64:84-91. Abstract/Full Text
Diffusion modifies the connectivity of kinetic schemes for multisite binding and catalysis.
Gopich IV, Szabo A.
Proc Natl Acad Sci U S A (2013 Dec 3) 110:19784-9. Abstract/Full Text
Diffusion along the splitting/commitment probability reaction coordinate.
Berezhkovskii AM, Szabo A.
J Phys Chem B (2013 Oct 24) 117:13115-9. Abstract/Full Text
Role of diffusion in the kinetics of reversible enzyme-catalyzed reactions.
Szabo A, Zhou HX.
Bull Korean Chem Soc (2012) 33:925-928. Abstract/Full Text
Time scale separation leads to position-dependent diffusion along a slow coordinate.
Berezhkovskii A, Szabo A.
J Chem Phys (2011 Aug 21) 135:074108. Abstract/Full Text
Diffusion-influenced ligand binding to buried sites in macromolecules and transmembrane channels.
Berezhkovskii AM, Szabo A, Zhou HX.
J Chem Phys (2011 Aug 21) 135:075103. Abstract/Full Text
Free energy profiles from single-molecule pulling experiments.
Hummer G, Szabo A.
Proc Natl Acad Sci U S A (2010 Dec 14) 107:21441-6. Abstract/Full Text
FRET efficiency distributions of multistate single molecules.
Gopich IV, Szabo A.
J Phys Chem B (2010 Nov 25) 114:15221-6. Abstract/Full Text
Protein dynamics from single-molecule fluorescence intensity correlation functions.
Gopich IV, Nettels D, Schuler B, Szabo A.
J Chem Phys (2009 Sep 7) 131:095102. Abstract/Full Text
Decoding the pattern of photon colors in single-molecule FRET.
Gopich IV, Szabo A.
J Phys Chem B (2009 Aug 6) 113:10965-73. Abstract/Full Text
Influence of the coupling of interdomain and overall motions on NMR relaxation.
Wong V, Case DA, Szabo A.
Proc Natl Acad Sci U S A (2009 Jul 7) 106:11016-21. Abstract/Full Text
Reactive flux and folding pathways in network models of coarse-grained protein dynamics.
Berezhkovskii A, Hummer G, Szabo A.
J Chem Phys (2009 May 28) 130:205102. Abstract/Full Text
Theory, analysis, and interpretation of single-molecule force spectroscopy experiments.
Dudko OK, Hummer G, Szabo A.
Proc Natl Acad Sci U S A (2008 Oct 14) 105:15755-60. Abstract/Full Text
Single-molecule FRET with diffusion and conformational dynamics.
Gopich IV, Szabo A.
J Phys Chem B (2007 Nov 8) 111:12925-32. Abstract/Full Text
Diffusion model of solute dynamics in a membrane channel: mapping onto the two-site model and optimizing the flux.
Bezrukov SM, Berezhkovskii AM, Szabo A.
J Chem Phys (2007 Sep 21) 127:115101. Abstract/Full Text
Extracting kinetics from single-molecule force spectroscopy: nanopore unzipping of DNA hairpins.
Dudko OK, Mathé J, Szabo A, Meller A, Hummer G.
Biophys J (2007 Jun 15) 92:4188-95. Abstract/Full Text