Yihong Ye, Ph.D.

Section Chief: Protein Stability and Quality Control Section, Laboratory of Molecular Biology

Scientific Focus Areas: Cell Biology, Chemical Biology, Molecular Biology and Biochemistry, Neuroscience

yihong.ye@nih.gov 301-594-0845 Add to Contacts

Publications

A selection of recent and significant publications can be viewed below.

Select Publications

Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells.

Lee JG, Takahama S, Zhang G, Tomarev SI, Ye Y.

Nat Cell Biol (2016 Jul) 18:765-76. Abstract/Full Text

Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells.

Lee JG, Baek K, Soetandyo N, Ye Y.

Nat Commun (2013) 4:1568. Abstract/Full Text

SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.

Xu Y, Cai M, Yang Y, Huang L, Ye Y.

Cell Rep (2012 Dec 27) 2:1633-44. Abstract/Full Text

The p97 ATPase associates with EEA1 to regulate the size of early endosomes.

Ramanathan HN, Ye Y.

Cell Res (2012 Feb) 22:346-59. Abstract/Full Text

Revoking the cellular license to replicate: yet another AAA assignment.

Ramanathan HN, Ye Y.

Mol Cell (2011 Oct 7) 44:3-4. Abstract/Full Text

Additional Publications

Regulation of protein homeostasis by unconventional protein secretion in mammalian cells.

Ye Y.

Semin Cell Dev Biol (2018 Nov) 83:29-35. Abstract/Full Text

DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins.

Xu Y, Cui L, Dibello A, Wang L, Lee J, Saidi L, Lee JG, Ye Y.

Cell Discov (2018) 4:11. Abstract/Full Text

A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.

Ye Y, Tang WK, Zhang T, Xia D.

Front Mol Biosci (2017) 4:39. Abstract/Full Text

Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains.

Liu C, Liu W, Ye Y, Li W.

Nat Commun (2017 Feb 6) 8:14274. Abstract/Full Text

The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation.

Xu Y, Anderson DE, Ye Y.

Cell Discov (2016) 2:16040. Abstract/Full Text

Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions.

Zhao Y, Zhang T, Huo H, Ye Y, Liu Y.

J Biol Chem (2016 Aug 26) 291:18252-62. Abstract/Full Text

Doa1 is a MAD adaptor for Cdc48.

Zhang T, Ye Y.

J Cell Biol (2016 Apr 11) 213:7-9. Abstract/Full Text

gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum.

Zhang T, Xu Y, Liu Y, Ye Y.

Mol Biol Cell (2015 Dec 1) 26:4438-50. Abstract/Full Text

In Search of a Cure for Proteostasis-Addicted Cancer: A AAA Target Revealed.

Xia D, Ye Y.

Cancer Cell (2015 Nov 9) 28:550-552. Abstract/Full Text

Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.

Mock JY, Chartron JW, Zaslaver M, Xu Y, Ye Y, Clemons WM Jr.

Proc Natl Acad Sci U S A (2015 Jan 6) 112:106-11. Abstract/Full Text

Cleaning up in the endoplasmic reticulum: ubiquitin in charge.

Christianson JC, Ye Y.

Nat Struct Mol Biol (2014 Apr) 21:325-35. Abstract/Full Text

Role of HERP and a HERP-related protein in HRD1-dependent protein degradation at the endoplasmic reticulum.

Huang CH, Chu YR, Ye Y, Chen X.

J Biol Chem (2014 Feb 14) 289:4444-54. Abstract/Full Text

Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains.

Liu W, Shang Y, Zeng Y, Liu C, Li Y, Zhai L, Wang P, Lou J, Xu P, Ye Y, Li W.

EMBO J (2014 Jan 7) 33:46-61. Abstract/Full Text

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.

Liu Y, Soetandyo N, Lee JG, Liu L, Xu Y, Clemons WM Jr, Ye Y.

Elife (2014) 3:e01369. Abstract/Full Text

Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum.

Huang CH, Hsiao HT, Chu YR, Ye Y, Chen X.

J Biol Chem (2013 Aug 30) 288:25330-9. Abstract/Full Text

A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.

Xu Y, Liu Y, Lee JG, Ye Y.

J Biol Chem (2013 Jun 21) 288:18068-76. Abstract/Full Text

Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation.

Lee JG, Ye Y.

Bioessays (2013 Apr) 35:377-85. Abstract/Full Text

Roles of p97-associated deubiquitinases in protein quality control at the endoplasmic reticulum.

Liu Y, Ye Y.

Curr Protein Pept Sci (2012 Aug) 13:436-46. Abstract/Full Text

TorsinA participates in endoplasmic reticulum-associated degradation.

Nery FC, Armata IA, Farley JE, Cho JA, Yaqub U, Chen P, da Hora CC, Wang Q, Tagaya M, Klein C, Tannous B, Caldwell KA, Caldwell GA, Lencer WI, Ye Y, Breakefield XO.

Nat Commun (2011 Jul 12) 2:393. Abstract/Full Text

A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.

Wang Q, Liu Y, Soetandyo N, Baek K, Hegde R, Ye Y.

Mol Cell (2011 Jun 24) 42:758-70. Abstract/Full Text

Proteostasis regulation at the endoplasmic reticulum: a new perturbation site for targeted cancer therapy.

Liu Y, Ye Y.

Cell Res (2011 Jun) 21:867-83. Abstract/Full Text

The ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory group.

Wang Q, Shinkre BA, Lee JG, Weniger MA, Liu Y, Chen W, Wiestner A, Trenkle WC, Ye Y.

PLoS One (2010 Nov 12) 5:e15479. Abstract/Full Text

The p97 ATPase dislocates MHC class I heavy chain in US2-expressing cells via a Ufd1-Npl4-independent mechanism.

Soetandyo N, Ye Y.

J Biol Chem (2010 Oct 15) 285:32352-9. Abstract/Full Text

Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps.

Magadán JG, Pérez-Victoria FJ, Sougrat R, Ye Y, Strebel K, Bonifacino JS.

PLoS Pathog (2010 Apr 29) 6:e1000869. Abstract/Full Text

Role of intramembrane charged residues in the quality control of unassembled T-cell receptor alpha-chains at the endoplasmic reticulum.

Soetandyo N, Wang Q, Ye Y, Li L.

J Cell Sci (2010 Apr 1) 123:1031-8. Abstract/Full Text

The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation.

Bernardi KM, Williams JM, Kikkert M, van Voorden S, Wiertz EJ, Ye Y, Tsai B.

Mol Biol Cell (2010 Jan 1) 21:140-51. Abstract/Full Text

Building ubiquitin chains: E2 enzymes at work.

Ye Y, Rape M.

Nat Rev Mol Cell Biol (2009 Nov) 10:755-64. Abstract/Full Text

Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD.

Lim PJ, Danner R, Liang J, Doong H, Harman C, Srinivasan D, Rothenberg C, Wang H, Ye Y, Fang S, Monteiro MJ.

J Cell Biol (2009 Oct 19) 187:201-17. Abstract/Full Text

Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2.

Li W, Tu D, Li L, Wollert T, Ghirlando R, Brunger AT, Ye Y.

Proc Natl Acad Sci U S A (2009 Mar 10) 106:3722-7. Abstract/Full Text

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells.

Wang Q, Mora-Jensen H, Weniger MA, Perez-Galan P, Wolford C, Hai T, Ron D, Chen W, Trenkle W, Wiestner A, Ye Y.

Proc Natl Acad Sci U S A (2009 Feb 17) 106:2200-5. Abstract/Full Text

The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation.

Li L, Soetandyo N, Wang Q, Ye Y.

Biochim Biophys Acta (2009 Feb) 1793:346-53. Abstract/Full Text

Polyubiquitin chains: functions, structures, and mechanisms.

Li W, Ye Y.

Cell Mol Life Sci (2008 Aug) 65:2397-406. Abstract/Full Text

Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling.

Li L, Hailey DW, Soetandyo N, Li W, Lippincott-Schwartz J, Shu HB, Ye Y.

Biochim Biophys Acta (2008 Jun) 1783:1140-9. Abstract/Full Text

Inhibition of p97-dependent protein degradation by Eeyarestatin I.

Wang Q, Li L, Ye Y.

J Biol Chem (2008 Mar 21) 283:7445-54. Abstract/Full Text

Structure and function of the yeast U-box-containing ubiquitin ligase Ufd2p.

Tu D, Li W, Ye Y, Brunger AT.

Proc Natl Acad Sci U S A (2007 Oct 2) 104:15599-606. Abstract/Full Text

A role for presenilin in post-stress regulation: effects of presenilin mutations on Ca2+ currents in Drosophila.

Lu Y, Lv Y, Ye Y, Wang Y, Hong Y, Fortini ME, Zhong Y, Xie Z.

FASEB J (2007 Aug) 21:2368-78. Abstract/Full Text

A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate.

Li W, Tu D, Brunger AT, Ye Y.

Nature (2007 Mar 15) 446:333-7. Abstract/Full Text

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3.

Wang Q, Li L, Ye Y.

J Cell Biol (2006 Sep 25) 174:963-71. Abstract/Full Text

Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila.

Seidner GA, Ye Y, Faraday MM, Alvord WG, Fortini ME.

Curr Biol (2006 May 23) 16:1026-33. Abstract/Full Text

Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane.

Ye Y, Shibata Y, Kikkert M, van Voorden S, Wiertz E, Rapoport TA.

Proc Natl Acad Sci U S A (2005 Oct 4) 102:14132-8. Abstract/Full Text

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.

Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA.

Nature (2004 Jun 24) 429:841-7. Abstract/Full Text

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains.

Ye Y, Meyer HH, Rapoport TA.

J Cell Biol (2003 Jul 7) 162:71-84. Abstract/Full Text

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.

Ye Y, Meyer HH, Rapoport TA.

Nature (2001 Dec 6) 414:652-6. Abstract/Full Text

Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster.

Ye Y, Fortini ME.

J Cell Biol (1999 Sep 20) 146:1351-64. Abstract/Full Text

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

Ye Y, Lukinova N, Fortini ME.

Nature (1999 Apr 8) 398:525-9. Abstract/Full Text