Jinwei Zhang, Ph.D., Stadtman Tenure-Track Investigator
Photo of Jinwei Zhang
Scientific Focus Areas: RNA Biology, Structural Biology, Molecular Biology and Biochemistry, Microbiology and Infectious Diseases, Biomedical Engineering and Biophysics


A selection of recent and significant publications can be viewed below.

Select Publications

Structural basis of R-loop recognition by the S9.6 monoclonal antibody.
Bou-Nader C, Bothra A, Garboczi DN, Leppla SH, Zhang J.
Nat Commun (2022 Mar 28) 13:1641. Abstract/Full Text
HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization.
Bou-Nader C, Muecksch F, Brown JB, Gordon JM, York A, Peng C, Ghirlando R, Summers MF, Bieniasz PD, Zhang J.
Cell Host Microbe (2021 Sep 8) 29:1421-1436.e7. Abstract/Full Text
High-affinity recognition of specific tRNAs by an mRNA anticodon-binding groove.
Suddala KC, Zhang J.
Nat Struct Mol Biol (2019 Dec) 26:1114-1122. Abstract/Full Text
Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions.
Li S, Su Z, Lehmann J, Stamatopoulou V, Giarimoglou N, Henderson FE, Fan L, Pintilie GD, Zhang K, Chen M, Ludtke SJ, Wang YX, Stathopoulos C, Chiu W, Zhang J.
Nat Struct Mol Biol (2019 Dec) 26:1094-1105. Abstract/Full Text
Crystal structure of an adenovirus virus-associated RNA.
Hood IV, Gordon JM, Bou-Nader C, Henderson FE, Bahmanjah S, Zhang J.
Nat Commun (2019 Jun 28) 10:2871. Abstract/Full Text

Additional Publications

Direct modulation of T-box riboswitch-controlled transcription by protein synthesis inhibitors.
Stamatopoulou V, Apostolidi M, Li S, Lamprinou K, Papakyriakou A, Zhang J, Stathopoulos C.
Nucleic Acids Res (2017 Sep 29) 45:10242-10258. Abstract/Full Text
Structure and mechanism of the T-box riboswitches.
Zhang J, Ferré-D'Amaré AR.
Wiley Interdiscip Rev RNA (2015 Jul-Aug) 6:419-33. Abstract/Full Text
Synthesis and applications of RNAs with position-selective labelling and mosaic composition.
Liu Y, Holmstrom E, Zhang J, Yu P, Wang J, Dyba MA, Chen D, Ying J, Lockett S, Nesbitt DJ, Ferré-D'Amaré AR, Sousa R, Stagno JR, Wang YX.
Nature (2015 Jun 18) 522:368-72. Abstract/Full Text
RNA-Puzzles Round II: assessment of RNA structure prediction programs applied to three large RNA structures.
Miao Z, Adamiak RW, Blanchet MF, Boniecki M, Bujnicki JM, Chen SJ, Cheng C, Chojnowski G, Chou FC, Cordero P, Cruz JA, Ferré-D'Amaré AR, Das R, Ding F, Dokholyan NV, Dunin-Horkawicz S, Kladwang W, Krokhotin A, Lach G, Magnus M, Major F, Mann TH, Masquida B, Matelska D, Meyer M, Peselis A, Popenda M, Purzycka KJ, Serganov A, Stasiewicz J, Szachniuk M, Tandon A, Tian S, Wang J, Xiao Y, Xu X, Zhang J, Zhao P, Zok T, Westhof E.
RNA (2015 Jun) 21:1066-84. Abstract/Full Text
Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.
Lageix S, Zhang J, Rothenburg S, Hinnebusch AG.
PLoS Genet (2015 Feb) 11:e1004991. Abstract/Full Text
Post-crystallization Improvement of RNA Crystal Diffraction Quality.
Zhang J, Ferré-D'Amaré AR.
Methods Mol Biol (2015) 1316:13-24. Abstract/Full Text
Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase.
Windgassen TA, Mooney RA, Nayak D, Palangat M, Zhang J, Landick R.
Nucleic Acids Res (2014 Nov 10) 42:12707-21. Abstract/Full Text
Global analysis of riboswitches by small-angle X-ray scattering and calorimetry.
Zhang J, Jones CP, Ferré-D'Amaré AR.
Biochim Biophys Acta (2014 Oct) 1839:1020-1029. Abstract/Full Text
Dramatic improvement of crystals of large RNAs by cation replacement and dehydration.
Zhang J, Ferré-D'Amaré AR.
Structure (2014 Sep 2) 22:1363-1371. Abstract/Full Text
Direct evaluation of tRNA aminoacylation status by the T-box riboswitch using tRNA-mRNA stacking and steric readout.
Zhang J, Ferré-D'Amaré AR.
Mol Cell (2014 Jul 3) 55:148-55. Abstract/Full Text
New molecular engineering approaches for crystallographic studies of large RNAs.
Zhang J, Ferré-D'Amaré AR.
Curr Opin Struct Biol (2014 Jun) 26:9-15. Abstract/Full Text
A flexible, scalable method for preparation of homogeneous aminoacylated tRNAs.
Zhang J, Ferré-D'Amaré AR.
Methods Enzymol (2014) 549:105-13. Abstract/Full Text
YbxF and YlxQ are bacterial homologs of L7Ae and bind K-turns but not K-loops.
Baird NJ, Zhang J, Hamma T, Ferré-D'Amaré AR.
RNA (2012 Apr) 18:759-70. Abstract/Full Text
Ribozymes and riboswitches: modulation of RNA function by small molecules.
Zhang J, Lau MW, Ferré-D'Amaré AR.
Biochemistry (2010 Nov 2) 49:9123-31. Abstract/Full Text
Role of the RNA polymerase trigger loop in catalysis and pausing.
Zhang J, Palangat M, Landick R.
Nat Struct Mol Biol (2010 Jan) 17:99-104. Abstract/Full Text