Event Details
Agenda
Event Details
Meeting Objectives
The NIDDK workshop on Translation Approaches for Pharmacotherapy Development for Acute Diarrhea is being held to identify new translational research opportunities for the development of new pharmacologic agents to treat acute diarrhea in adults and in children. The workshop will bring together investigators to discuss the current understanding and challenges of acute diarrhea treatment, the pathogenesis of acute diarrhea and the pathophysiologic mechanisms involved. The workshop will also encompass translational approaches now being used and prospective approaches that may be developed to target common pathophysiologic mechanisms.
Extramural Organizers
- David Alpers, Washington University
- Henry J. Binder, Yale University
- Thomas Brewer, The Bill and Melinda Gates Foundation
- Mark Donowitz, Johns Hopkins University
Agenda
September 25, 2011
- 5:45 p.m. - 6:00 p.m.
- Welcome and NIDDK Priorities
Griffin Rodgers
Director, National Institute of Diabetes and Digestive and Kidney Diseases
- 6:00 p.m. - 6:10 p.m.
- Welcome and Review of Meeting Objectives and Agenda
Stephen James
Session I: Acute Diarrhea: Current Understanding and Challenges
Moderator: James Nataro
- 6:10 p.m. - 7:30 p.m.
- Epidemiology, Risk Factors, Clinical Manifestations, and Outcomes
Sean Moore
- Current Pharmacology and Unmet Medical Needs
Henry J. Binder
- Therapeutic Challenges and Translational Approaches to Diarrhea Prevention and Treatment in Under-Developed Nations
Olivier Fontaine
- Primary Discussant
David A. Sack
- Panel Discussion
September 26, 2011
Session II: Pathogenesis
Moderator: Gail Hecht
- 8:30 a.m. - 10:35 a.m.
- Common Pathways in Pathogenesis: Clues for Potential Targets
Kim Barrett
- Inflammatory Bacterial Diarrhea: Inflammatory and Immune Mediators and Epithelial Damage
Gail Hecht
- Toxin-Mediated Bacterial Diarrheas
Wayne Lencer
- Viral Diarrheal Diseases
Mary K. Estes
- Host Response to Acute Diarrhea Due to Parasites
William A. Petri
- Impact of Intestinal Microbiota on Pathogen Susceptibility
James Versalovic
- Primary Discussant: Novel Approaches to Oral Rehydration and Nutrition Therapy (ORNT)
Richard Guerrant
- Panel Discussion
- 10:35 a.m. - 11:00 a.m.
- Break
Session III: Pathophysiologic Mechanisms
Session III A: Transporters and Channels
Moderator: James Anderson
- 11:00 a.m. - 12:45 p.m.
- Overview of Pathophysiologic Mechanisms
Mark Donowitz
- Preclinical Models: From Cultured Cells and Organoids to Animal Models and Biopsies
Hugo de Jonge
- Overview of the Role of Cl channels
Nadia Ameen
- Role of CFTR vs Calcium-Activated Chloride Channels in Intestinal Cl Secretion
Alan Verkman
- Role of Trafficking in the Regulation of CFTR Function
Raymond Frizzell
- Role of CFTR and Its Interacting Partners in Cholera Toxin-Induced Diarrhea
Anjaparavanda Naren
- KCNMA1 K Channels Mediate K-Dependent Intestinal Fluid Ssecretion: A Potential Anti-Secretory Target
Vazhaikkurichi Rajendran
- 12:45 p.m. - 1:45 p.m.
- Working Lunch and Poster Session
Session III A: Pathopysiologic Mechanisms (Continued)
- 1:45 p.m. - 3:15 p.m.
- Regulation of Intestinal Na Absorption: NHE3
Mark Donowitz
- Regulation of Intestinal Chloride Absorption: SLC26 Transporters
Pradeep Dudeja
- Pathways of Intestinal Epithelial Water Transport and Molecular Mechanisms of Its Regulation
Olga Kovbasnjuk
- Calcium Sensing Receptor (CaSR) Regulation of Intestinal Ion Transporters
John Geibel
- Primary Discussant
Fayez Ghishan
- Panel Discussion
- 3:15 p.m. - 3:30 p.m.
- Break
Session III B: Paracellular Transport and Motility
Moderator: Jerrold Turner
- 3:30 p.m. - 5:30 p.m.
- Inflammatory Diarrhea: New Approaches to Drugging the Junction
Jerrold Turner
- Mechanisms of Epithelial Barrier Disturbance in Inflammatory Bowel Disease
Joerg-Dieter Schulzke
- Primary Discussant
James Anderson
- Panel Discussion
- Neuromuscular/Nerve-Gut, EC cells, Motility
Terez Shea-Donohue
- Review of Enteroendocrine and Neuromuscular Mechanisms in the Pathophysiology of Acute Diarrhea
Michael Camilleri
- Panel Discussion
Session IV: Breakout Groups for Sessions I, II, IIIA, IIIB, and IV
- 5:30 p.m. - 7:00 p.m.
- Breakout Groups
September 27, 2011
- 8:30 a.m. - 8:40 a.m.
- Summary of Days 1 and 2
James Nataro and James Anderson
Session V: Translation of Current Understanding of Pathophysiological Mechanisms into Potential Treatment Options
Moderator: David Alpers
- 8:40 a.m. - 10:00 a.m.
- Developmental Strategy for Approaching Druggable Targets
Alan Verkman
- Challenges of Drug Development for Diarrhea
David Brown
- Development of a CFTR Inhibitor as a Potential Treatment for Acute Secretory Diarrhea
Tue Nguyen
- Overview of NIH Molecular Libraries Program
Ronald Margolis
- Primary Discussant
Henry J. Binder
- Panel Discussion
- 10:00 a.m. - 10:25 a.m.
- Break
Session VI: Breakout Reports
Moderators: Mark Donowitz and Session Moderators
- 10:25 a.m. - 11:15 a.m.
- Breakout Reports
Session VII: Final Discussion
- 11:15 a.m. - 12:15 p.m.
- Knowledge Gaps, Opportunities and Priorities
David Alpers
- 12:15 p.m. - 12:30 p.m.
- Closing Remarks/Adjournment
Stephen James
