Quantitative Morphology in Kidney Research
- Review the principles of stereological analysis, including design-based and model-based methods, and their application to kidney research using animal and human tissue, with a focus on accurate determination of glomerular number and podocyte number.
- Review the range of valid histomorphometric methods that can be used to generate estimates of these parameters, with varying degrees of precision and accuracy.
- Discuss what preclinical and clinical studies will be required prior to any kidney morphology parameter being accepted as a surrogate marker to facilitate drug development.
- Review novel approaches using in vivo imaging techniques to assess kidney tissue structure.
- Consider additional quantitative kidney tissue measurements (e.g., capillary density).
John Bertram, Monash University, Australia
Agnes Fogo, Vanderbilt University
Kevin Lemley, University of Southern California Co-Chair
Michael Mauer, University of Minnesota
Roger Wiggins, University of Michigan
Jeffrey Kopp, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Co-Chair
Paul Kimmel, NIDDK
Marva Moxey-Mims, NIDDKK
Robert Nelson, NIDDK
Steve Hewitt, National Cancer Institute