Event Details
Agenda
Event Details
Meeting Objectives
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces a workshop focused on elucidating the roles of recently described brown and beige/brite fat in people. Speakers will describe state-of-the-art technology for monitoring human brown adipose tissue (hBAT) mass and function, and present recent basic and clinical data. Plenary talks, selected “hot topic” presentations, and a poster session will provide a forum for interactions among basic scientists and clinical researchers.
Scientific Focus
- Physiological Functions and Clinical Relevance of hBAT: The 2013 Perspective
- Classical and Inducible Brown, Beige, Brite, B/B Fat in Humans
- Measuring hBAT Activity: Pushing the Limits of Position Emission Tomography/Computed Tomography (PET/CT)
- hBAT as a Therapeutic Target: Investigations in Different Populations
- Measuring hBAT Mass and Activity: Emerging Approaches
- Novel Roles of hBAT: Thinking Outside the Box
Planning Committee
Aaron Cypess (Joslin Diabetes Center, Harvard University)
Carol Haft (NIDDK, NIH, HSS)
Houchun Harry Hu (Children's Hispital Los Angeles)
Maren Laughlin (NIDDK, NIH, HHS)
Agenda
October 15, 2013
- 7:30 a.m.
- Registration (Lister Hill Auditorium, NIH Campus)
- 8:15 a.m. – 8:30 a.m.
- Opening Remarks/Meeting Overview
Carol Haft and Maren Laughlin, NIDDK, NIH
Aaron Cypess, Joslin Diabetes Center, Harvard University
Houchun Harry Hu, Children’s Hospital, Los Angeles
Session I: Physiological Functions and Clinical Relevance of Human BAT (T): The 2013 Perspective
Kong Chen (Moderator)
- 8:30 a.m.
- Six Years with Adult Human Brown Adipose Tissue
Jan Nedergaard, Stockholm University, Sweden
- 9:00 a.m.
- Treating Metabolic Disease Through Pharmacological Activation of Human BAT
Aaron Cypess, n Diabetes Center, Harvard University
- 9:30 a.m.
- Fat Depots and Bone: the Role of Human BAT
Anne Klibanski, Massachusetts General Hospital
- 10:00 a.m.
- Brown and Beige Fat: Basic Biology and Novel Therapeutic Opportunities
Bruce Spiegelman, Dana Farber Cancer Institute, Harvard Medical School
- 10:30 a.m. – 11:00 a.m.
- Break
Session II: Measuring Human BAT Activity: Pushing the Limits of PET/CTL
Madar (Moderator)
- 11:00 a.m.
- Does Cold-Activated Brown Fat Contribute Significantly to Daily Energy Expenditure?
Otto Muzik, Wayne State University School of Medicine
- 11:15 a.m.
- Novel Approaches to Investigating Fatty Acid Metabolism in Human BAT
Kirsi Virtanen, University of Turku and Turku University Hospital, Finland
- 11:30 p.m.
- The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
Yu-Shin Ding, New York University School of Medicine
- 11:45 p.m.
- Insight into the Functional Organization of Human BAT
Igal Madar, Johns Hopkins University School of Medicine
- 12:00 p.m.
- Imaging of Brown Fat Metabolism using Hyperpolarized Carbon-13 MRI
Lanette Friesen-Waldner, University of Western Ontario, London
- 12:15 p.m. – 2:00 p.m.
- Poster Session and Lunch Buffet in Atrium
Session III: Classical and Inducible Brown, Beige, Brite, B/B Fat in Humans
Barbara Cannon (Moderator)
- 2:00 p.m.
- Deciphering Brown Adipogenesis from a Progenitor and Inductive Signaling Perspective
Yu-Hua Tseng, Joslin Diabetes Center, Harvard Medical School
- 2:30 p.m.
- New Tools to Understand the Molecular Circuits of Beige/Brite Cell Development
Shingo Kajimura, University of California, San Francisco
- 3:00 p.m.
- Human Epicardial Fat is a Unique Adipose Depot with Limited Brown Fat Signature that is Altered in Coronary Artery Disease
Elizabeth McAninch, University of Miami
- 3:20 p.m.
- Brown Fat Dynamics: Elucidation of Molecular Drivers Based on the Innate Expertise of a Hibernator
Sandra L. Martin, University of Colorado School of Medicine, Aurora
- 3:40 p.m. – 4:00 p.m.
- Break
Session IV: Measuring Human BAT Mass and Activity: Emerging Approaches
Houchun Harry Hu (Moderator)
- 4:00 p.m.
- Brown Adipose Tissue Quantification Using Magnetic Resonance Imaging
E. Brian Welch, Vanderbilt University Medical Center
- 4:15 p.m.
- Brown Adipose Tissue Perfusion: From Mice to Men
Marielle Scherrer-Crosbie, Massachusetts General Hospital
- 4:30 p.m.
- Detecting BAT Mass and Thermogenic Activity by Using Nonlinear 1H MRI and Hyperpolarized 129Xe Gas MRI
Rosa Tamara Branca, University of North Carolina, Chapel Hill
- 4:45 p.m.
- Passive and Active Microwave Radiometry for Non-Invasive Detection of Human Brown Fat
Fred Sterzer, MMTC, Inc.
- 5:00 p.m.
- Peptide Probes for Targeted Brown Adipose Tissue Imaging
Mikhail G. Kolonin, University of Texas Health Science Center, Houston
- 5:15 p.m.
- Adjournment
October 16, 2013
- 7:30 a.m. – 8:00 a.m.
- Registration (Lister Hill Auditorium, NIH Campus
- 7:55 a.m.
- Opening Remarks
Griffin Rodgers, NIDDK Director
Session V: Human BAT as a Therapeutic Target
Rebecca Brown (Moderator)
- 8:00 a.m.
- Effect of Ambient Temperature on Human Brown Fat Activity and Recruitment
Wouter van Marken Lichtenbelt, Maastricht University Medical Center, The Netherlands
- 8:30 a.m.
- Exploring the Roles of Brown Fat in Children
Vicente Gilsanz, Children’s Hospital Los Angeles
- 9:00 a.m.
- Signal Transduction Pathways Converging to Promote “Brown(ing)” Adipocytes
Sheila Collins, Sanford-Burnham Medical Research Institute
- 9:30 a.m.
- Brown Adipose Tissue Improves Glucose Metabolism and Whole Body Insulin Sensitivity in Humans
Maria Chondronikola, University of Texas Medical Branch, Galveston
- 9:50 a.m. – 10:15 a.m.
- Break
- 10:15 a.m.
- Acute Cold Exposure Elicits Increases in BAT Oxidative Metabolism in Individuals with Type 2 Diabetes
Denis Blondin, Université de Sherbrooke
- 10:35 a.m.
- Autologous Matrix Assisted Cell Transplantation as a Strategy for the Expansion of Human BAT
Andreas Stahl, UC Berkeley
Session VI: Human BAT Research: Future Directions
Houchun Harry Hu and Aaron Cypess (Moderators)
- 11:00 a.m.
- Open Floor Discussion of Research Gaps and Opportunities
- What are the potential physiological roles for adult human BAT/Beige/Brite cells?
- What technologies, in addition to imaging or temperature detection, are needed to assess the role(s) of adult human BAT?
- Is there more to be learned from the regarding the role(s) of adult human BAT?
- Are epidemiologic studies of human BAT needed?
- Impact of climate and environment
- Impact of exercise and diet
- Impact of age, gender, body composition, genetics
- Unique populations
- 12:00 p.m. – 1:30 p.m.
- Poster Session and Lunch Buffet
Session VII: Novel Role(s) of Human BAT: Thinking Outside
the Box
Ronald Kahn (Moderator)
- 1:30 p.m.
- Novel Mechanisms in the Control of Brown and White Fat Development and Function
C. Ronald Kahn, Joslin Diabetes Center, Harvard University
- 1:45 p.m.
- Targeting Lipolysis to Fuel Adipocyte Thermogenesis
James Granneman, Wayne State University
- 2:15 p.m.
- Insights From Understanding CNS Pathways in Regulating the Sympathetic Outflow to BAT
Shaun Morrison, Oregon Health and Science University
- 2:45 p.m.
- Inactivation of Type 2 Deiodinase in Adipose Tissue Increases the Expression of Skeletal Muscle-Specific Genes in Neonatal Mouse Hind Limb and in E18.5 Brown Adipose Tissue
Antonio Bianco, University of Miami Medical School
- 3:15 p.m.
- Brown Adipose Tissue and Sleep Regulation
Éva Szentirmai, Washington State University, Spokane
- 3:35 p.m.
- Does Sarcolipin and Muscle Based Thermogenesis Compensate in BAT Deficient Mammals?
Muthu Periasamy, Ohio State University, Columbus
- 3:55 p.m.
- Closing Remarks
- 4:15 p.m.
- Adjournment
