The intent of this conference is to provide a state-of-the-science overview on the effects of diabetes on cellular systems relevant to urologic complications: smooth muscle, autonomic nervous system, endothelium, and vasculature, and to discuss how this knowledge can be leveraged for urologic research.Speakers and participants will discuss how best to integrate the basic science expertise and knowledge with clinical urology expertise to identify basic research priorities.
Tracy Rankin, Ph.D., National Institute of Diabetes and Digestive and Kidney Diseases
Kristin Abraham, Ph.D., National Institute of Diabetes and Digestive and Kidney Diseases
Simon J. Gibbons, Ph.D., Mayo Clinic
Ziya Kirkali, M.D., National Institute of Diabetes and Digestive and Kidney Diseases
Robert S. Moreland, Ph.D., Drexel University
Aruna Sarma, Ph.D., University of Michigan
February 14, 2013
- 8:30 a.m.
- Introduction to the Workshop and Statement of Overall Goals
Tracy Rankin, Ph.D., NIDDK
Robert Star, M.D., NIDDK
Session I: Epidemiology of Urologic Complications
- 8:45 a.m.
- What are the Known Unknowns?
Hunter Wessells, M.D., University of Washington
Leslee Subak, M.D., University of California, San Francisco
Jennifer St. Sauver, Ph.D., Mayo Clinic
- 10:30 a.m.
- Breakout Session I: Presentation of Outstanding Questions/Goals/Issues
Session II: Smooth and Cardiac Muscle Physiology
- 11: 00 a.m.
- Coronary Smooth Muscle Ca 2+ Dysregulation in Metabolic Syndrome Swine: Principles for Urologic Smooth Muscle
Michael Sturek, Ph.D., Indiana University School of Medicine
- Neuropilin 2: A New Player in Bladder Pathophysiology?
Rosalyn Adam, Ph.D., Children's Hospital Boston
- A Trek to Understanding Diabetes' (and Obesity's) Effects on the Heart Muscle
Linda Peterson, M.D., Washington University School of Medicine at St. Louis
- 12:45 p.m.
- Lunch Break
- 2:00 p.m.
- Special Presentation: Basic Science Foundation of Translational Research in Regenerative Medicine
Anthony Atala, M.D., Wake Forest University
Session III: Inflammation and Fibrosis
- 2:45 p.m.
- Inflammation and Fibrosis Promote Lower Urinary Tract Dysfunction
Jill Macoska, Ph.D., University of Michigan
- PAF Signaling in Kidney Inflammation, Dysfunction, and Fibrosis
Thomas McIntyre, Ph.D., Cleveland Clinic
- The Role of Inflammation in Pulmonary Fibrosis
Erica Herzog, M.D., Ph.D., Yale University
Session IV: Neural Responses and Central Mechanisms
- 4:15 p.m.
- Cellular and Molecular Basis for Diabetic Gastroparesis
Gianrico Farrugia, M.D., Mayo Clinic
- Nitrinergic Pathways and Diabetes
Pankaj "Jay" Pasricha, M.D., The Johns Hopkins University
- Mitochondrial Function in Diabetic Neuropathy
James Russell, M.D., M.S., University of Maryland
- 6:00 p.m.
- Day 1 Wrap-up/Discussion
- 6:30 p.m.
- Dinner on your own
February 15, 2013
Session V: Bioenergetics/Oxidative Stress
- 8:30 a.m.
- Inflammation and Protein Carbonylation
David Bernlohr, Ph.D., University of Minnesota
- Role of mTORC1 Activation in the Development of Diabetic Nephropathy
Kenneth Inoki, M.D., Ph.D., University of Michigan
Robert Balaban, Ph.D., National Heart, Lung, and Blood Institute, NIH
Session VI: Resources and Tools
- 10:15 a.m.
- The GUDMAP Database: A Resource for Urologic Research
Chad Vezina, Ph.D.; and Bruce Aronow, University of Wisconsin and Cincinnati Children's
- Mining Human Biosamples for Mechanism and Targets in Diabetic End Organ Complications
Matthias Kretzler, M.D., University of Michigan
- Applications of Metabolomics in Urology
Susan Sumner, Ph.D., Research Triangle Institute
- 12:00 p.m.
- Breakout Session II: Coming Back to the Original Questions in the Context of the Science Presented; Prioritization by Topic Area for Research Moving Forward-What is Most Important to Investigate First?
- 1:00 p.m.
- Meeting Summation and Adjournment