Total Pancreatectomy With Islet Auto-Transplantation (TP-IAT)

Event Details

The purpose of the “Total Pancreatectomy with Islet Auto-Transplantation (TP-IAT): Gaps, Needs, and Opportunities” Workshop is to explore the knowledge gaps, the requirements to advance the more widespread use of this therapy, and the research opportunities for improving the results of this approach to the treatment of chronic pancreatitis. This 1-day workshop, co-chaired by Dr. Melena Bellin of the University of Minnesota and Dr. Andres Gelrud from the University of Chicago, will feature presentations by an international group of experts who will discuss the indications, selection of candidates, and information needed to improve the outcomes of patients. The workshop is open to both clinicians and scientists currently involved in TP-IAT programs and to individuals who are considering starting new TP-IAT programs. Admission to the program is without charge, but preregistration is required.

TP-IAT Organizing Committee

Co-Chairs

Melena Bellin, University of Minnesota
bell0130@umn.edu

Andres Gelrud, University of Chicago
agelrud@bsd.uchicago.edu

Members

David B. Adams, Medical University of South Carolina
adamsdav@musc.edu

Dana Andersen, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
dana.andersen@nih.gov

Michael Appel, NIDDK
appelm@niddk.nih.gov

Appakalai Balamurugan, University of Minnesota
bala@umn.edu

Greg Beilman, University of Minnesota
beilm001@umn.edu

Sherry Brown, NIDDK
Sherry.Brown@nih.gov

Thomas Eggerman, NIDDK
eggermant@extra.niddk.nih.gov

Michael Rickels, University of Pennsylvania Perelman School of Medicine
rickels@mail.med.upenn.edu

Jose Serrano, NIDDK
serranoj@extra.niddk.nih.gov

Vikesh Singh, The Johns Hopkins University
vsingh1@jhmi.edu

David C. Whitcomb, University of Pittsburgh
whitcomb@pitt.edu

Agenda

July 23, 2014

8:00 a.m.

Introduction
Drs. Melena Bellin and Andres Gelrud

Session 1: Patient Selection, Indications, and Timing

Moderators: Drs. Melena Bellin and Andres Gelrud

8:20 – 8:40 a.m.

Refining and Standardizing Patient Selection
Dr. Vikesh Singh

8:40 – 9:00 a.m.

Selecting the Best Therapy: TP-IAT vs. Other Surgical Options
Dr. David Adams

9:00 – 9:20 a.m.

Selecting the Best Therapy: TP-IAT vs. Endoscopic Options
Dr. Martin Freeman

9:20 – 9:40 a.m.

Economic Considerations and Barriers to TP-IAT
Dr. Ashley Dennison

9:40 – 10:00 a.m.

Break

Session 2: Technical Aspects TP-IAT

Moderators: Drs. Katherine Morgan and Bashoo Naziruddin

10:00 – 10:20 a.m.

Total Pancreatectomy: Optimizing Surgical Approach and Reducing Complications
Dr. Greg Beilman

10:20 – 10:40 a.m.

Optimizing Islet Isolation from the Diseased Pancreas
Dr. A. N. Balamurugan

10:40 – 11:00 a.m.

Alternative Implantation Sites
Dr. Andrew Posselt

Session 3: Improving Success of Islet Auto-Transplantation

Moderators: Drs. Cristiana Rastellini and Michael Rickels

11:00 – 11:20 a.m.

Lessons from Allo-Transplantation
Dr. Michael Rickels

11:20 – 11:40 a.m.

Enhancing Islet Engraftment and Survival
Dr. Melena Bellin

11:40 a.m. – 12:00 p.m.

Islet Function After TP-IAT
Dr. Paul Robertson

12:00 – 1:20 p.m.

Lunch

12:30 – 1:00 p.m.

Standards and Regulatory Requirements for IAT
Dr. Kurt Wonnacott

Session 4: Improving Outcomes After Total Pancreatectomy

Moderators: Drs. Sarah Schwarzenberg and Syed Ahmad

1:20 – 1:40 p.m.

Addressing Pain After TP-IAT
Dr. Pankaj "Jay" Pasricha

1:40 – 2:00 p.m.

GI Dysmotility and Related GI Co-Morbidities After TP-IAT
Dr. Ellen Stein

2:00 – 2:20 p.m.

Pancreatic Enzyme and Nutritional Deficiencies
Dr. Andres Gelrud

2:20 – 2:40 p.m.

TP-IAT in Children, Patients with Genetic Abnormalities: The Pediatric GI Perspective
Dr. Mark Lowe

2:40 – 3:00 p.m.

TP-IAT Outcomes in Children: The Surgical Perspective
Dr. Srinath Chinnakotla

3:00 – 3:20 p.m.

Break

Session 5: Registry Considerations for TP-IAT

Moderators: Drs. Michael Appel and Abhinav Humar

3:20 – 3:40 p.m.

Lessons from the CITR
Dr. Franca Barton

3:40 – 4:00 p.m.

What Characteristics Should be Collected and Assessed Before Surgery?
Dr. David Whitcomb

4:00 – 4:20 p.m.

What Measures Should be Collected After Surgery?
Dr. Marlon Levy

Panel Discussion

Moderator: Dr. Jeffrey Matthews

Panelists:
Drs. Franca Barton, David Whitcomb, Horacio Rilo, Marlon Levy, and Melena Bellin

4:50 – 5:00 p.m.

Wrap-up, Adjournment
Drs. Melena Bellin and Andres Gelrud