Advances in Biomedical Imaging, Bioengineering, and Related Technologies for the Development of Biomarkers of Pancreatic Disease

Event Details

Sponsored by

National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Biomedical Imaging and Bioengineering
The National Pancreas Foundation

Background

Benign and malignant pancreatic disease is frequently diagnosed at an advanced stage of disease due to the absence of accurate and sensitive biomarkers of early disease. Exocrine and endocrine insufficiency do not become apparent until the disease is advanced, due to the inherent functional reserve of the healthy pancreas. Conventional imaging methods are usually inadequate to confirm a diagnosis of early benign (e.g., chronic pancreatitis) or malignant (e.g., pancreatic ductal adenocarcinoma or PDAC) disease. As a result, there are no therapeutic agents available to reverse or prevent the progression of benign inflammation, and only 20 percent of patients with PDAC are candidates for curative therapy (of which more than half develop recurrent disease.)

Purpose

Recent advances in biomedical imaging, bioengineering, and related technologies offer new approaches to diagnosing the presence and stage of benign and malignant pancreatic diseases at an early time point in their course. The purpose of the planned workshop is to explore these advances to inform the community of clinician investigators who might want to evaluate these advances in clinical studies, and to inform the program officials at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and other agencies who are considering new initiatives for future funding opportunities.

Logistical Plan

The workshop will be designed as a 1-day workshop open to the public, and will be held at the University of Pittsburgh immediately prior to the start of the annual PancreasFest meeting on July 22, 2015. The workshop will consist of a number of invited expert speakers and moderators who will explore topics chosen by a multidisciplinary organizing committee. NIDDK will authorize an external meeting planning group, The Scientific Consulting Group, Inc. (SCG) of Gaithersburg, MD, to assist with the meeting logistics. Plans for the workshop, including topics, speaker selection and design of the workshop sessions, discussion of possible poster presentations, and engagement with other stakeholders will be the responsibility of the Organizing Committee.

Organizing Committee

Dana Andersen, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases

Randall Brand, M.D.
University of Pittsburgh

Teri Brentnall, M.D.
University of Washington

Tony Hollingsworth, M.D.
University of Nebraska

Marybeth Hughes, M.D.
National Cancer Institute

Kimberly Kelly, Ph.D.
University of Virginia

Christina Liu, Ph.D.
National Cancer Institute

Tony Sastre, Ph.D.
National Institute of Biomedical Imaging and Bioengineering

Jose Serrano, M.D., Ph.D.
National Institute of Diabetes and Digestive and Kidney Diseases

Sudhir Srivastava, M.D.
National Cancer Institute

David Whitcomb, M.D., Ph.D.
University of Pittsburgh

Agenda

Jul 22, 2015

7:30 a.m. – 8:00 a.m.

Registration

8:00 a.m. – 8:10 a.m.

Welcome
Dr. Kim Kelly
Dr. Tony Hollingsworth

8:10 a.m. – 8:30 a.m.

Introduction to Workshop
Dr. David Whitcomb

Session 1: New Approaches to the Diagnosis of Chronic Pancreatitis

Moderators: Drs. Dhiraj Yadav and Vikesh Singh

8:30 a.m. – 8:55 a.m.

Non-invasive MR Imaging of Fibrosis and Inflammation
Dr. Richard Ehman, Mayo Clinic

8:55 a.m. – 9:20 a.m.

Non-invasive Detection of Fibrosis by EUS and EUS-Elastography in Chronic Pancreatitis
Dr. Julia Mayerle, University Medicine Greifswald, Greifswald, Germany

9:20 a.m. – 9:45 a.m.

Functional Markers of Chronic Pancreatitis
Dr. Darwin Conwell, Ohio State University

9:45 a.m. – 10:05 a.m.

Break

Session 2: Biomarkers of Pain and Inflammation

Moderators: Drs. Tony Hollingsworth and Ajay Wasan

10:05 a.m. – 10:30 a.m.

Biomarkers of Pain
Dr. Tony Hollingsworth, Eppley Cancer Institute

10:30 a.m. – 10:55 a.m.

Imaging Pancreatic Inflammation
Dr. Aida Habtezion, Stanford University

10:55 a.m. – 11:20 a.m.

Functional Imaging of Zn(II) Release from Secretory Cells by MRI
Dr. A. Dean Sherry, University of Texas Southwestern

11:20 a.m. – 11:45 a.m.

Assessing Pancreatic Disease by Proteomics
Dr. Hanno Steen, Boston Children's Medical Center

11:45 a.m. – 12:00 p.m.

Panel Discussion and Recommendations
Panelists: Drs. Conwell, Ehman, Habtezion, Hollingsworth, Mayerle, Sherry, and Steen
Moderator: Dr. Yadav

12:00 p.m. – 1:00 p.m.

Lunch

12:30 p.m. – 1:00 p.m.

Keynote: New Approaches to the Detection and Diagnosis of Pancreatic Disease
Dr. Chris Contag, Stanford University

Session 3: New Approaches to the Detection of Pancreatic Cancer

Moderators: Drs. Christina Liu and Randall Brand

1:00 p.m. – 1:25 p.m.

Non-invasive Molecular Imaging in Pancreatic Cancer
Dr. Kimberly Kelly, University of Virginia

1:25 p.m. – 1:50 p.m.

Imaging PDAC With Ultrasound Molecular Imaging
Dr. Juergen Willmann, Stanford University (via GoTo Meeting)

1:50 p.m. – 2:15 p.m.

Imaging CA19-9 in PDAC
Dr. Jason Lewis, Memorial Sloan Kettering Cancer Center

2:15 p.m. – 2:40 p.m.

Magnetic Resonance Imaging of Pancreatic Adenocarcinoma Using Dynamic Contrast Enhancement
Dr. Erin Gilbert, Oregon Health & Sciences University

2:40 p.m. – 3:05 p.m.

Markers of Pancreatic Cancer-induced Diabetes
Dr. Suresh Chari, Mayo Clinic

3:05 p.m. – 3:25 p.m.

Break

Session 4: Shed Exomes, Shed Cells and Shed Proteins

Moderators:  Drs. Kim Kelly and Sudhir Srivastava

3:25 p.m. – 3:50 p.m.

Detecting Shed Exosomes in PDAC via Microfluidics
Dr. Hakho Lee, Massachusetts General Hospital

3:50 p.m. – 4:15 p.m.

Detecting Shed Cancer Cells in PDAC
Dr. Andrew Rhim, University of Michigan

4:15 p.m. – 4:40 p.m.

HHigh Throughput Identification, Synthesis and Screening of Peptides
Dr. Julie Sutcliff, University of California, Davis

4:40 p.m. – 5:00 p.m.

Panel Discussion and Recommendations
Panelists: Drs. Chari, Gilbert, Kelly, Lee, Lewis, Rhim, Sutcliffe, and Willmann
Moderator: Dr. Brand

5:00 p.m.

Adjournment