Functional Role of Microbiome in Obesity
Obesity is a multifactorial condition, affected by altered energy balance resulting in increased adiposity. It has been shown to be highly influenced by genetics and lifestyle factors, such as diet and physical activity, and, as more recently documented, by environmental factors, such as gut microbiota. Recent evidence suggests that gut microbiome composition can predict body composition (lean and obese) with 90 percent accuracy, compared to 60 percent accuracy with genetic composition, and the microbiome plays an important role in the outcomes associated with weight loss interventions. However, the functional relevance of microbial dysbiosis to the pathophysiology of obesity, or the exact nature of microbial changes associated with weight loss interventions and their relevance to obesity reduction, needs to be clearly established. Finally, the potential of microbiome-targeted therapies for obesity treatment still needs to be explored.
In order to deliberate the current evidence on the functional association between the microbiome and energy balance, to further explore microbial-targeted strategies for treating obesity, and to identify the research gaps and opportunities in the field, a focused workshop has been organized to engage microbiome and obesity experts in an interactive discussion. Invited experts will develop a set of relevant questions and research ideas for each topic that will serve as guidance for the discussions that will follow each brief presentation. Proceedings of the workshop will be published in a scientific journal.
Padma Maruvada, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Andrew Bremer, NIDDK
Robert Karp, NIDDK
Peter Perrin, NIDDK
Philip Smith, NIDDK
Susan Yanovski, NIDDK
Phillip Daschner, National Cancer Institute (NCI)
Sharon Ross, NCI
Cindy Davis, Office of Dietary Supplements (ODS)
Pothur Srinivas, National Heart, Blood, and Lung Institute (NHLBI)
Drs. Lee M. Kaplan and Eugene B. Chang
December 1, 2015