Hemodialysis Vascular Access: Taking The Next Steps

Event Details

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), is pleased to announce the workshop on Hemodialysis Vascular Access. This meeting will take place September 16–17, 2015, and will be held at the Natcher Conference Center on the NIH Main Campus in Bethesda, MD. The purpose of the workshop is to review the state-of-the-art knowledge of the clinical, epidemiological, and basic research aspects of arteriovenous fistulas and grafts to support maintenance hemodialysis.

Planning Group
Workshop on Hemodialysis Vascular Access
September 16-17, 2015

Roster

Michael Allon, M.D. (Planning Group Leader)
Professor of Medicine
University of Alabama at Birmingham
Birmingham, Alabama

Kevin C. Abbott, M.D., M.P.H.
Director, Kidney and Urology Epidemiology
Division of Kidney, Urologic and Hematologic Diseases (DKUHD)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institutes of Health (NIH)
Bethesda, Maryland

Dennis Bandyk, M.D., F.A.C.S.
Professor of Surgery
University of California-San Diego School of Medicine
La Jolla, California

Daniel Gossett, Ph.D.
Health Specialist, Small Business Programs
DKUHD, NIDDK, NIH

John W. Kusek, Ph.D.
Senior Scientific Advisor
DKUHD, NIDDK, NIH

C. Keith Ozaki, M.D., F.A.C.S.
John A Mannick Professor of Surgery
Brigham and Women’s Hospital
Harvard Medical School
Boston, Massachusetts

Surendra Shenoy, M.D., Ph.D.
Professor of Surgery
Washington University School of Medicine
St. Louis, Missouri

Roberto I. Vazquez-Padron, Ph.D.
Associate Professor of Surgery
University of Miami Leonard M. Miller School of Medicine
Miami, Florida

Agenda

September 16, 2015

7:00 a.m. – 8:00 a.m.

Registration

8:00 a.m. – 8:10 a.m.

Welcome from NIDDK
Robert Star, Division of Kidney, Urologic, and Hematologic Diseases (KUH), NIDDK

8:10 a.m. – 8:20 a.m.

Overview of the Workshop
Michael Allon, The University of Alabama at Birmingham School of Medicine.

Epidemiology of Vascular Access and Factors Associated with Arteriovenous Fistula (AVF) Development and Maturation

Moderator: Michael Allon, The University of Alabama at Birmingham School of Medicine

8:20 a.m. – 8:40 a.m.

Recent U.S. Trends in Vascular Access: Data from DOPPS and USRDS/CrownWeb
Rajiv Saran, University of Michigan Medical School

8:40 a.m. – 9:00 a.m.

Postoperative Ultrasound Changes in AVF Diameter and Blood Flow in the Hemodialysis Fistula Maturation (HFM) Study and Their Association with Clinical AVF Maturation
Michelle Robbin, The University of Alabama at Birmingham School of Medicine

9:00 a.m. – 9:20 a.m.

Clinical Factors Affecting Postoperative AVF Diameter and Blood Flow and Clinical Maturation in the HFM Study
Scott Berceli, University of Florida

9:20 a.m. – 9:40 a.m.

Preoperative Vascular Function Tests and Their Association with Postoperative AVF Diameter and Blood Flow and Clinical Maturation in the HFM Study
Laura Dember, University of Pennsylvania Perelman School of Medicine

9:40 a.m. – 10:00 a.m.

FDA Perspective: What Are Acceptable Outcome Measures for Intervention/Treatment Studies of Hemodialysis Vascular Access?
Brian Pullin, U.S. Food and Drug Administration

10:00 a.m. – 10:20 a.m.

Break

Improving Vascular Access Outcomes

Moderators: Dennis Bandyk, University of California, San Diego School of Medicine, and Tom Huber, University of Florida College of Medicine

10:20 a.m. – 10:35 a.m.

Optimal Use of Imaging and Surgical Techniques to Improve Access Outcomes
Tom Huber, University of Florida College of Medicine

10:35 a.m. – 10:50 a.m.

Long-term Vascular Access Planning: AVF, Arteriovenous Graft (AVG), or Central Venous Catheter (CVC)?
Karen Woo, Keck School of Medicine of the University of Southern California

10:50 a.m. – 11:05 a.m.

What Is the Optimal Timing of Predialysis Vascular Access?
Matthew Oliver, Sunnybrook Health Sciences Centre

11:05 a.m. – 11:20 a.m.

Percutaneous Interventions to Salvage Nonmaturing AVF
Monnie Wasse, Northwestern University Feinberg School of Medicine

11:20 a.m. – 11:40 a.m.

Processes of Care That Affect Clinical AVF Maturation—Results from the HFM Study
Alfred Cheung, The University of Utah Health Sciences Center

11:40 a.m. – 11:55 a.m.

Changing Processes of Care to Convert Catheter-dependent HD Patients to Permanent Access
George Blessios, Mercy Hospital Dialysis Access Center

11:55 a.m. – 12:10 p.m.

Drug Interventions to Prevent Access Failure: Results of Major RCTs
Charmaine Lok, University Health Network, University of Toronto

12:10 p.m. – 1:30 p.m.

Lunch

Biology of Vascular Access Failure and Potential Molecular Targets

Moderators: Roberto Vazquez-Padron, University of Miami Miller School of Medicine, and Timmy Lee, The University of Alabama at Birmingham School of Medicine

1:30 p.m. – 1:45 p.m.

Overview of Failing AVF and AVG
Prabir Roy-Chaudhury, University of Arizona

1:45 p.m. – 2:05 p.m.

Preexisting Vascular Pathology and Its Association with Postoperative AVF Diameter and Blood Flow and Clinical Maturation—Findings from the HFM Study
Charles Alpers, University of Washington School of Medicine

2:05 p.m. – 2:25 p.m.

Preexisting Venous Intimal Hyperplasia and Its Impact on Postoperative Neointimal Hyperplasia and Clinical AVF Outcomes
Roberto Vazquez-Padron, University of Miami Miller School of Medicine

2:25 p.m. – 2:45 p.m.

Impact of Preexisting Arterial and Venous Pathology on Clinical AVF and AVG Outcomes
Michael Allon, The University of Alabama at Birmingham School of Medicine

2:45 p.m. – 3:00 p.m.

Hemodynamic Changes and Vascular Access Outcomes
Andrea Remuzzi, Mario Negri Institute

3:00 p.m. – 3:15 p.m.

Molecular Targets in Experimental Models of AVF and AVG Failure
Sanjay Misra, Mayo Clinic

3:15 p.m. – 3:30 p.m.

Molecular Targets in Clinical AVF and AVG Failure
Timmy Lee, The University of Alabama at Birmingham School of Medicine

3:30 p.m. – 4:00 p.m.

Break

Industry Roundtable: Future Directions to Prevent Vascular Access Failure and Perspective on Conducting Clinical Trials of Hemodialysis Vascular Access

Moderator: Keith Ozaki, Brigham and Women’s Hospital

4:00 p.m. – 4:15 p.m.

Use of Elastase to Improve AVF Maturation
Steve Burke, Proteon Therapeutics, Inc.

4:15 p.m. – 4:30 p.m.

Tissue Engineered Scaffolds for Improved AVGs (Humacyte)
Jeff Lawson, Duke University Medical Center

4:30 p.m. – 4:45 p.m.

Sirolimus Wraps
Sriram Iyer, Vascular Therapies, Inc.

4:45 p.m. – 5:00 p.m.

Optiflow Device
Adam Dakin, Bioconnect Systems, Inc.

5:00 p.m. – 5:15 p.m.

Open Discussion: Opportunities and Challenges in the Business of Improving Vascular Access Outcomes
Industry Speakers and Participants

5:15 p.m. – 5:30 p.m.

Charge to the Breakout Sessions
Michael Allon, The University of Alabama at Birmingham School of Medicine

5:30 p.m.

Adjournment for the Day

September 17, 2015

7:30 a.m. – 8:30 a.m.

Industry-sponsored breakfast and poster session

8:30 a.m. – 12:00 p.m.

Concurrent Breakout Sessions

• How Can We Improve Processes of Care to Reduce Catheter Use in HD Patients?
  Moderators: Dennis Bandyk, University of California, San Diego School of Medicine, and Karen Woo, Keck School of Medicine of the University of Southern California
• Emerging Percutaneous and Surgical Interventions to Improve Vascular Access Outcomes
  Moderators: Keith Ozaki, Brigham and Women’s Hospital, and Monnie Wasse, Northwestern University Feinberg School of Medicine
• Promising Pharmacologic Approaches to Prevention of Vascular Access Failure
  Moderators: Roberto Vazquez-Padron, University of Miami Miller School of Medicine, and Timmy Lee, The University of Alabama at Birmingham School of Medicine
• Future Epidemiologic Studies and Clinical Trials of Vascular Access
  Moderators: Charmaine Lok, University Health Network, University of Toronto, and Prabir Roy-Chaudhury, University of Arizona

12:00 p.m. – 1:00 p.m.

Lunch

Summary and Recommendations from the Breakout Sessions

Moderator: Michael Allon, The University of Alabama at Birmingham School of Medicine

1:00 p.m. – 1:20 p.m.

GROUP 1: Presentation and Discussion
Dennis Bandyk, University of California, San Diego School of Medicine, and
Karen Woo, Keck School of Medicine of the University of Southern California

1:20 p.m. – 1:40 p.m.

GROUP 2: Presentation and Discussion
Keith Ozaki, Brigham and Women’s Hospital, and
Monnie Wasse, Northwestern University Feinberg School of Medicine

1:40 p.m. – 2:00 p.m.

GROUP 3: Presentation and Discussion
Roberto Vazquez-Padron, University of Miami Miller School of Medicine, and
Timmy Lee, The University of Alabama at Birmingham School of Medicine

2:00 p.m. – 2:20 p.m.

GROUP 4: Presentation and Discussion
Charmaine Lok, University Health Network, University of Toronto, and
Prabir Roy-Chaudhury, University of Arizona

Concluding Remarks

2:20 p.m. – 2:40 p.m.

Meeting Summary
Michael Allon, The University of Alabama at Birmingham School of Medicine

2:40 p.m. – 2:50 p.m.

Concluding Remarks
Robert Star, KUH, NIDDK

2:50 p.m.

Adjournment