Mechanistic and molecular studies in animal models demonstrate that disruptions in circadian rhythms and/or the molecular components of central and peripheral clock proteins profoundly influence glucose and lipid metabolism as well as body adiposity. Epidemiological evidence in humans also suggests that sleep disruption is associated with increased body weight and impaired glucose tolerance. However, a number of scientific gaps remain. Currently, the individual mechanisms that mediate the differential effects on metabolism of the circadian clock, the sleep-wake cycle, and the timing of feeding have not been identified. Furthermore, the translation of these findings has only been applied to humans in limited approaches. To determine if and how modulation of sleep/circadian rhythms and timing of feeding can be used to attenuate and perhaps treat the growing epidemic of obesity and type 2 diabetes, it is essential to move the field forward and identify the mechanisms that link sleep and metabolism. In addition, it is important to determine which clinical populations would be most responsive to sleep modulation, and if chronotherapy could be applied to the treatment of obesity and diabetes. The goals of this workshop are to: 1) bring together experts in the field of circadian regulation, sleep, and glucose/lipid metabolism; 2) review the current state of knowledge in human and nonhuman models; and, with this background, 3) determine the appropriate methodologies and studies that need to be conducted to establish whether modulating sleep and circadian rhythms can effectively contribute to the treatment of obesity and diabetes.
February 19, 2015
- 7:30 a.m.
Session I: Sleep Disruption and Sleep Disorders: Effects on Metabolic Disease
- 8:00 a.m.
Karen Teff and Corinne Silva, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- 8:05 a.m.
- Sleep Disturbances, Circadian Dysfunction, and Diabetes Risk
Eve Van Cauter, University of Chicago
- 8:45 a.m.
- Obstructive Sleep Apnea and Diabetes: Clinical Studies and Mechanisms
Allan Pack, University of Pennsylvania
Session II: Neural Regulation of Energy Balance, Sleep, and Circadian Rhythms
- 9:25 a.m.
- Using Mouse Genetics to Unravel the CNS Pathways Regulating Energy Balance and Glucose Homeostasis
Joel Elmquist, The University of Texas Southwestern Medical Center
- 9:50 a.m.
- Regulation of Circadian Rhythms in Nocturnal and Diurnal Mammals
Etienne Challet, University of Strasburg
- 10:15 a.m.
- Sleep Restriction, Circadian Misalignment, and Metabolic Disorders: Clock Gene Dysregulation as a Final Common Pathway?
Paul Franken, University of Lausanne
- 10:40 a.m.
- Welcome and Opening Remarks
Griffin P. Rodgers, Director, NIDDK
- 10:45 a.m.
Session III: Mechanisms of Sleep and Circadian Disruptions on Metabolism
- 11:00 a.m.
- Circadian Genomics of Diabetes and Human Islet Cell Biology
Joseph Bass, Northwestern University
- 11:25 a.m.
- Time-Restricted Feeding Is a Preventative and Therapeutic Intervention Against Metabolic Diseases
Satchin Panda, Salk Institute
- 11:50 a.m.
- From Metabolism to Epigenetics: The Circadian Link
Paolo Sassone-Corsi, University of California, Irvine
- 12:15 p.m.
Session IV: Approaches to Understanding the Mechanisms Contributing to Glucose Homeostasis
- 1:15 p.m.
- Metabolically Normal and Abnormal Obesity
Sam Klein, Washington University in St. Louis School of Medicine
- 1:40 p.m.
- Adipose Tissue Inflammation: Role in Insulin Resistance
Philip Kern, University of Kentucky
- 2:05 p.m.
- Hypoglycemia, Counter-regulation, and Sleep
Elizabeth Seaquist, University of Minnesota
- 2:30 p.m.
- Do the Carotid Bodies Link Sleep Disorders, Diabetes, and the ANS?
Michael Joyner, Mayo Clinic
- 2:55 p.m.
- 3:15 p.m.
- Genetics of Type 2 Diabetes
Richa Saxena, Harvard Medical School
- 3:40 p.m.
- What mechanisms mediating the effects of sleep disruption/circadian misalignment on metabolism have recently been identified?
- How do these mechanisms overlap/integrate with pathways known to contribute to glucose dysregulation in humans?
- How could methodologies used in measuring glucose metabolism be incorporated into sleep disruption/circadian misalignment studies?
- 5:00 p.m.
February 20, 2015
Session V: Current/Ongoing Studies on Sleep and Circadian Disruptions in Humans
- 8:00 a.m.
- Separate Effects of Endogenous Circadian System, Behavioral Cycle, and Circadian Misalignment on Metabolism in Humans
Frank Scheer, Brigham and Women's Hospital/Harvard Medical School
- 8:25 a.m.
- Impact of Insufficient Sleep and Circadian Misalignment on Metabolism in Humans
Kenneth Wright, University of Colorado
- 8:50 a.m.
- Teasing Apart the Impact of Prior Exposure to Recurrent Circadian Disruption and Chronic Sleep Restriction on Pancreatic β-Cell Responsiveness
Charles Czeisler, Brigham and Women's Hospital/Harvard Medical School
- 9:15 a.m.
- 10:00 a.m.
- Genetic Traits of the Human Clock and Sleep Homeostat Can Inform Other Phenotypes
Louis Ptacek, University of California, San Francisco
- 10:25 a.m.
- The State of the Art on the Bidirectional Association Between OSA and Metabolic Dysfunction
Naresh Punjabi, The Johns Hopkins University
- 10:50 a.m.
- What are the optimal interventions of sleep and circadian rhythms that will address their mechanistic role in human metabolism?
- What outcome measures of metabolism should be used to elucidate the mechanisms by which sleep and/or circadian dysregulation influence metabolism in humans?
- What population of those with disrupted glucose/lipid metabolism or phenotypic population should be targeted so as to have the best chance of optimal outcome?
- 1:00 p.m.