Overcoming Barriers in Acute Kidney Injury (AKI)
AKI is a common, deadly complication of medical and surgical illnesses, which more frequently affects African Americans, those with diabetes mellitus, the elderly, and those with chronic kidney disease (CKD). Outcomes associated with AKI include progressive diminution of renal function in those with CKD, loss of renal function in those with previously normal renal function, the development and progression of cardiovascular disease, and increased disability and decreased quality of life.
The purpose of the workshop is to facilitate the development and testing of therapies that may have a meaningful impact on clinical outcomes of AKI. This may entail the development of clinically relevant animal models that mimic Phase 2 and 3 clinical trial designs, identification of new druggable cellular and molecular targets, new pharmacological screening methodologies, and advances in clinical trials in the field. As in the past, industry participation in the workshop will be encouraged. This multidisciplinary meeting will bring together basic and clinical scientists to propose (a) pilot and feasibility projects on the development of clinically relevant animal models of AKI, and (b) clinical trials designed in specific patient populations to ameliorate short- and long-term outcomes of AKI. The long-term goal is to stimulate research using novel animal models, by developing new therapies and proposing clinically relevant, feasible clinical trials.
This workshop will review present AKI research and make recommendations regarding needed changes. The outcome of this workshop will be a report outlining the gaps in evidence that need to be filled, which will be made available to the research community. Each of the speakers or discussion group leaders will provide a summary of his/her session after the meeting so a formal report may be developed. It is envisioned that the workshop report will provide important new information for AKI research communities—especially for those within the NIDDK mission.
Natcher Conference Center
Balconies A, B, & C
National Institutes of Health
Bethesda, MD 20894