Effects of Aging on Hematopoiesis
Americans are living longer than ever. The Census Bureau expects that by 2030 one of every five Americans will be age 65 or older. As a result, the focus on diseases that must be addressed by the United States health care system is shifting toward those of older adults. Older adults are faced with a significant burden of non-malignant hematologic disease. The etiologies of anemias, clonal hematopoiesis, idiopathic cytopenia of undetermined significance, and myelodysplastic syndromes are largely unknown, hindering rational diagnosis, treatment, and prevention. Specific hypotheses concerning normal aging of blood stem cells and their progenitors are poised to be tested. Furthermore, we must develop a greater understanding of the pathogenesis of non-malignant hematologic disease in older adults. This workshop will consider the gaps in our knowledge and technology that are barriers to our understanding of the basic biology that regulates hematopoiesis in older organisms. The workshop will also provide an opportunity for the research community to cooperatively consider the essential next steps for the field. We expect that closing such gaps will establish a foundation critical to improving our ability to diagnose, treat, and prevent non-malignant hematologic disease in older adults.
January 27, 2016