Effects of Aging on Hematopoiesis

Event Details

Background

Americans are living longer than ever. The Census Bureau expects that by 2030 one of every five Americans will be age 65 or older. As a result, the focus on diseases that must be addressed by the United States health care system is shifting toward those of older adults. Older adults are faced with a significant burden of non-malignant hematologic disease. The etiologies of anemias, clonal hematopoiesis, idiopathic cytopenia of undetermined significance, and myelodysplastic syndromes are largely unknown, hindering rational diagnosis, treatment, and prevention. Specific hypotheses concerning normal aging of blood stem cells and their progenitors are poised to be tested. Furthermore, we must develop a greater understanding of the pathogenesis of non-malignant hematologic disease in older adults. This workshop will consider the gaps in our knowledge and technology that are barriers to our understanding of the basic biology that regulates hematopoiesis in older organisms. The workshop will also provide an opportunity for the research community to cooperatively consider the essential next steps for the field. We expect that closing such gaps will establish a foundation critical to improving our ability to diagnose, treat, and prevent non-malignant hematologic disease in older adults.

Registration Deadline

January 27, 2016

Agenda

January 28, 2016

Location: Natcher Balcony A/B, Bldg. 45, NIH Campus

Please note the change in location - all registrants are welcome to attend.

National Institute on Aging (NIA) Special Session

Moderator: Rebecca Fuldner, Ph.D.

5:00 p.m.

Introduction and Welcome
NIA staff

5:15 p.m.

Intrinsic and Extrinsic Signals Regulating Hematopoietic Stem Cell Aging
Amy Wagers, Ph.D., Harvard Stem Cell Institute, Harvard University

5:45 p.m.

Preventing Iatrogenic Hematopoietic Stem Cells (HSC) Aging
Norman Sharpless, M.D., The University of North Carolina School of Medicine

6:30 p.m.

Dinner on your own

January 29, 2016

Location: Lister Hill Auditorium, Bldg. 38A, NIH Campus

8:00 a.m.

Introduction and Welcome
NIDDK staff

Session 1: Clonal Hematopoiesis

Moderator: Terry Bishop, Ph.D.

8:15 a.m.

Clonal Hematopoiesis and Aging
Benjamin Ebert, M.D., Harvard Stem Cell Institute; Dana-Farber Cancer Institute

8:45 a.m.

In vivo Stem Cell Clonal Dynamics
Fernando Camargo, Ph.D., Harvard Stem Cell Institute; Boston Children’s Hospital

9:15 a.m.

Director’s Welcoming Remarks
Griffin P. Rodgers, M.D., M.A.C.P., Director, NIDDK

Session 2: Epigenetics

Moderator: John Thomas, Ph.D.

9:30 a.m.

HSCs in the Context of Aging and of Dnmt3a Ablation
Margaret Goodell, Ph.D., Baylor College of Medicine

10:00 a.m.

Diminished Apoptotic Priming Underlies Increased Survival of Aged HSCs in Response to DNA Damage
Derrick Rossi, Ph.D., Harvard Stem Cell Institute; Harvard University

10:30 a.m.

Break

Session 3: Lymphoid versus Myeloid Commitment

Moderator: Manjit Hanspal, Ph.D.

11:00 a.m.

HSCs, Autophagy and Aging
Emmanuelle Passegué, Ph.D., University of California, San Francisco

11:30 a.m.

Evolving Patterns of Lymphopoiesis from Embryogenesis Through Senescence
Kenneth Dorshkind, Ph.D., University of California, Los Angeles

12:00 p.m.

The Impact of Aging on Hematopoietic Stem/Progenitor Cells in Non-human Primates as Interrogated by Genetic Barcoding
Cynthia Dunbar, M.D., National Heart, Lung, and Blood Institute

12:30 p.m.

DNA Damage Checkpoints in Hematopoietic Stem Cells Influence Immune Functions and Leukemogenesis in Aging
K. Lenhard Rudolph, M.D., Leibniz Institute on Aging

1:00 p.m.

Lunch and Poster Session

Session 4: Aging Microenvironment

Moderator: John Williams, Ph.D.

2:30 p.m.

Aging Alters the Bone Marrow Microenvironment
Laura Calvi, M.D., University of Rochester School of Medicine

3:00 p.m.

Effects of Bone on Hematopoietic Aging and Disease
Stavroula Kousteni, Ph.D., Columbia University

Wrap up: Themes and Future Directions
Moderator: Terry Bishop, Ph.D.

3:30 p.m.

Margaret Goodell, Ph.D., Baylor College of Medicine

3:45 p.m.

Next Steps and Future Directions
NIDDK Staff

4:30 p.m.

Adjournment