Emerging Role of Branched-Chain Amino Acids in Human Diseases

May 25 - 26, 2017 Contacts

Registration Closed

Registration ended Jan. 1, 0001

Event Details Agenda

Background

The branched chain amino acids (BCAA) leucine, isoleucine and valine are essential nutrients, required for normal growth and protein balance. Cellular sensing of BCAAs (e.g., leucine) and their metabolites alters signal transduction cascades to regulate metabolism and gene expression. Recent advancements have implicated BCAAs as an important and integral nutritional factor and biomarker in major health domains (performance, body mass, satiety) and human diseases (metabolic disorders, cancer, sarcopenia, along with neurological and cardiovascular diseases). The purpose of this conference is to identify opportunities and gaps in the field in order to promote multi-disciplinary research on BCAA actions and metabolism over a broad spectrum of human health and disease.

Meeting Objectives

With the recent plethora of high impact papers getting attention from the public and private sectors, the field is ready for a major update on BCAA metabolism. A deeper understanding of the regulation of BCAA inter-organ and intracellular metabolism could reveal new therapeutic targets to promote health, treat disease and/or improve the lifespan. The conference will help identify key gaps in our current knowledge and infrastructure, from which a published report would be expected to emerge.

Organizing Committee

Tracy Anthony, Ph.D., Rutgers University
Yibin Wang, Ph.D., UCLA
Christopher Lynch, Ph.D., Office of Nutrition Research, NIDDK, NIH
Abby G. Ershow, Sc.D., R.D., FAHA, Office of Dietary Supplements, NIH
Rebecca B. Costello, Ph.D., Office of Dietary Supplements, NIH
Daniel J. Raiten, Ph.D., NICHD, NIH
Jonathan Scott, Ph.D., R.D., Consortium for Health and Military Performance (CHAMP)

Registration Deadline

In-person and webcast registration for this workshop is CLOSED.

May 25, 2017

7:30 a.m. – 9:00 a.m.: Arrival and Registration

Session I: BCAA Mechanisms – What is Known, What are the Knowledge Gaps

9:00 a.m. – 9:20 a.m.: Introduction/Overview of Morning Session
Christopher Lynch, Ph.D., ONR
9:20 a.m. – 9:55 a.m.: BCAA Metabolism: Lessons from Inborn Errors of Metabolism
Brendan Lee, M.D., Ph.D., Baylor College of Medicine
9:55 a.m. – 10:30 a.m.: BCAA Regulation of mTORC1; Targeting the Cellular Leucine Sensor for a New Generation of Therapeutics
Shomit Sengupta, Ph.D., Navitor Pharmaceuticals
10:30 a.m. – 10:40 a.m.: Welcome
Griffin P. Rodgers, M.D., M.A.C.P., Director, NIDDK
10:40 a.m. – 10:50 a.m.: Break
10:40 a.m. – 11:25 a.m.: BCAA and Protein Turnover
Scot Kimball, Ph.D., Penn State College of Medicine
11:25 a.m. – 12:00 p.m.: Role of HMB in attenuating muscle loss
Suzette L Pereira, Ph.D., Abbott Nutrition
11:45 a.m. – 12:15 p.m.: Session I Panel Discussion
12:15 p.m. – 1:15 p.m.: Lunch and working group business meeting 1 (Knowledge and Infrastructure Gap)

Session II: BCAA in Disease

1:15 p.m. – 1:30 p.m.: Introduction/Overview of Session
Yibin Wang, Ph.D., UCLA
1:30 p.m. – 2:05 p.m.: Translating BCAA signatures of cardiometabolic diseases to underlying mechanisms
Christopher Newgard, Ph.D., Duke University School of Medicine
2:05 p.m. – 2:40 p.m.: BCAA Catabolism and Insulin Resistance
Mary-Elizabeth Patti, M.D., Joslin Diabetes Center
2:40 p.m. – 3:15 p.m.: BCAA Flux: A Novel Mechanism and Therapeutic Target for Diabetes
Haipeng Sun, Ph.D., UCLA JTUSOM
3:15 p.m. – 3:30 p.m.: Break
3:30 p.m. – 4:05 p.m.: BCAA Catabolic Defects in Heart Failure and Cardioprotection
Rong Tian, M.D., Ph.D. University of Washington
4:05 p.m. – 4:40 p.m.: Novel Function of BCAA Metabolite in Insulin Resistance
Zoltan Arany, M.D. Ph.D., University of Pennsylvania
4:40 p.m. – 5:15 p.m.: Adaptability to exercise training and energy metabolism during exercise in mice with muscle-specific deletion of BDK
Yoshiharu Shimomura, Ph.D., Nagoya University, Japan
5:15 p.m. – 5:30 p.m.: Session II Panel Discussion
6:30 p.m.: Dinner and working group business meeting 2 (BCAA in Disease Knowledge and Infrastructure Gaps)

May 26, 2017

7:30 a.m. – 8:30 a.m.: Breakfast on own

Session III: BCAA as Therapy

8:30 a.m. – 8:45 a.m.: Introduction/Overview of Session
Tracy Anthony, Ph.D., Rutgers University
8:45 a.m. – 9:20 a.m.: BCAA and Neonatal Growth
Teresa Davis, Ph.D., Baylor College of Medicine
9:20 a.m. – 9:55 a.m.: Sarcopenia of Aging
Blake Rasmussen, Ph.D., University of Texas Medical Branch at Galveston
9:55 a.m. – 10:05 a.m.: Break
10:05 a.m. – 10:40 a.m.: Branched-chain Amino Acids in Exercise
Stuart Phillips, Ph.D., McMaster University
10:40 a.m. – 11:15 a.m.: BCAA and Recovery from Catabolic Injury
Elisabet Børsheim, Ph.D., Arkansas Children’s Nutrition Center
11:15 a.m. – 11:50 a.m.: BCAA in Military Performance and Maintenance of Lean Body Mass
Stefan Pasiakos, Ph.D., US Army Research Institute of Environmental Medicine (USARIEM)
11:50 a.m. – 12:05 a.m.: Session III Panel Discussion
12:05 p.m. – 12:15 p.m.: Concluding Remarks
Christopher Lynch, Ph.D., ONR
12:15 p.m. – 1:15 p.m.: Lunch and working group business meeting 3 (BCAA as Therapy Knowledge and Infrastructure Gaps)

Registration Closed

Registration ended Jan. 1, 0001

Location

Building 31/6C
Conference Room 6
31 Center Drive, NIH Campus
Bethesda, MD 20892

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Contacts

Program Contact
Chris Lynch, Ph.D.
NIDDK
T: 301-827-3988

Meeting Logistics
Kimberly Barch
NIDDK

Emerging Role of Branched-Chain Amino Acids in Human Diseases

Registration

Event Details