Emerging Role of Branched-Chain Amino Acids in Human Diseases
The branched chain amino acids (BCAA) leucine, isoleucine and valine are essential nutrients, required for normal growth and protein balance. Cellular sensing of BCAAs (e.g., leucine) and their metabolites alters signal transduction cascades to regulate metabolism and gene expression. Recent advancements have implicated BCAAs as an important and integral nutritional factor and biomarker in major health domains (performance, body mass, satiety) and human diseases (metabolic disorders, cancer, sarcopenia, along with neurological and cardiovascular diseases). The purpose of this conference is to identify opportunities and gaps in the field in order to promote multi-disciplinary research on BCAA actions and metabolism over a broad spectrum of human health and disease.
With the recent plethora of high impact papers getting attention from the public and private sectors, the field is ready for a major update on BCAA metabolism. A deeper understanding of the regulation of BCAA inter-organ and intracellular metabolism could reveal new therapeutic targets to promote health, treat disease and/or improve the lifespan. The conference will help identify key gaps in our current knowledge and infrastructure, from which a published report would be expected to emerge.
Tracy Anthony, Ph.D., Rutgers University
Yibin Wang, Ph.D., UCLA
Christopher Lynch, Ph.D., Office of Nutrition Research, NIDDK, NIH
Abby G. Ershow, Sc.D., R.D., FAHA, Office of Dietary Supplements, NIH
Rebecca B. Costello, Ph.D., Office of Dietary Supplements, NIH
Daniel J. Raiten, Ph.D., NICHD, NIH
Jonathan Scott, Ph.D., R.D., Consortium for Health and Military Performance (CHAMP)
In-person and webcast registration for this workshop is CLOSED.