Endoscopic Ultrasound and Related Technologies for the Diagnosis and Treatment of Pancreatic Disease: Research Gaps and Opportunities

Event Details

Background

Endoscopic ultrasound (EUS) provides the highest resolution images of the pancreas and has become widely used in the diagnosis and management of benign and malignant pancreatic disease. EUS-based criteria are used for the diagnosis of chronic pancreatitis; for the localization and identification of mass lesions; and for the capture of fluid, tissue, and cells to enable the diagnosis of cystic and solid lesions of the pancreas.

Purpose

Despite its widespread adoption, EUS methodology is evolving. Criteria for clinical performance and reporting are not uniform, training requirements are variable, and new EUS-based methods for diagnosis and treatment are being developed for clinical validation studies. The purpose of the planned workshop is to explore these advances, inform the community of clinician investigators, and identify research gaps that might shape future funding initiatives by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and other agencies.

Logistical Plan

The 1-day workshop will be open to the public and will be held at the University Club on the campus of the University of Pittsburgh immediately prior to the start of the annual PancreasFest meeting on July 26, 2017. The workshop will consist of a number of invited expert speakers and moderators who will explore topics chosen by a multidisciplinary organizing committee. The NIDDK will authorize an external meeting planning group, The Scientific Consulting Group, Inc. (SCG) of Gaithersburg, Maryland, to assist with the meeting logistics. Plans for the workshop—including topics, speaker selection, design of the workshop sessions, discussion of possible poster presentations, and engagement with other stakeholders—will be the responsibility of the organizing committee.

Organizing Committee

Co-Chairs

Dr. Linda S. Lee
Brigham and Women’s Hospital–Harvard University

Dr. Vikesh K. Singh
Johns Hopkins University

Members

Dr. Dana K. Andersen
National Institute of Diabetes and Digestive and Kidney Diseases

Dr. Joo Ha Hwang
University of Washington

Dr. Kevin M. McGrath
University of Pittsburgh

Dr. Walter G. Park
Stanford University

Dr. Jose Serrano
National Institute of Diabetes and Digestive and Kidney Diseases

Dr. Tyler Stevens
The Cleveland Clinic

Dr. Mark D. Topazian
Mayo Clinic–Rochester

Dr. Michael B. Wallace
Mayo Clinic–Jacksonville

Dr. Sachin Wani
University of Colorado

Dr. David Whitcomb
University of Pittsburgh

Dr. Juergen K. Willmann
Stanford University

Dr. Dhiraj Yadav
University of Pittsburgh

Faculty List

Dana Andersen
National Institute of Diabetes and Digestive and Kidney Diseases
Email: dana.andersen@nih.gov

Reiko Ashida
Osaka Medical Center for Cancer and Cardiovascular Disease
Email: rashida@goo.jp

Bill Brugge
Massachusetts General Hospital, Harvard Medical School
Email: wbrugge@partners.org

Mimi Canto
Johns Hopkins Medical Institutions
Email: mcanto@jhmi.edu

Ken Chang
University of California, Irvine
Email: kchang@uci.edu

Suresh Chari
Mayo Clinic, Rochester
Email: chari.suresh@mayo.edu

John DeWitt
Indiana University School of Medicine
Email: jodewitt@iu.edu

Joo Ha Hwang
University of Washington School of Medicine
Email: jooha@medicine.washington.edu

Mouen Khashab
Johns Hopkins University School of Medicine
Email: mkhasha1@jhmi.edu

Kang Kim
University of Pittsburgh
Email: kangkim@upmc.edu

Linda Lee
Brigham and Women’s Hospital, Harvard Medical School
Email: lslee@partners.org

Mike Levy
Mayo Clinic, Rochester
Email: levy.michael@mayo.edu

Kevin McGrath
University of Pittsburgh
Email: mcgrathkm@upmc.edu

Walter Park
Stanford University School of Medicine
Email: wgpark@stanford.edu

Vikesh Singh
Johns Hopkins Hospital
Email: vsingh1@jhmi.edu

Thomas Smyrk
Mayo Clinic, Rochester
Email: smyrk.thomas@mayo.edu

Tyler Stevens
Cleveland Clinic
Email: stevent@ccf.org

Chris Thompson
Brigham and Women’s Hospital, Harvard Medical School
Email: cthompson@hms.harvard.edu

Mark Topazian
Mayo Clinic, Rochester
Email: topazian.mark@mayo.edu

Irving Waxman
University of Chicago
Email: iwaxman@medicine.bsd.uchicago.edu

Michael Wallace
Mayo Clinic, Jacksonville
Email: wallace.michael@mayo.edu

Dhiraj Yadav
University of Pittsburgh
Email: yadavd@upmc.edu

Sachin Wani
University of Colorado
Email: sachin.wani@ucdenver.edu

Agenda

July 26, 2017

7:30 a.m. – 8:00 a.m.

Registration

8:00 a.m. – 8:10 a.m.

Welcoming Remarks
Linda Lee and Vikesh Singh, Co-chairs

8:10 a.m. – 8:35 a.m.

Introduction and Overview—Pancreatic EUS in 2017: Where Have We Been and Where Are We Going?
Michael Wallace

Session 1: EUS Performance and Interpretation in Benign Pancreatic Diseases

Moderators: Walter Park and Dhiraj Yadav

8:35 a.m. – 9:00 a.m.

Standards for Assessing Competency in Performance of Pancreatic EUS
Sachin Wani

9:00 a.m. – 9:25 a.m.

Can EUS Differentiate Normal Pancreas from Minimal Change Chronic Pancreatitis and Other Pancreatopathies?
Tyler Stevens

9:25 a.m. – 9:50 a.m.

Can EUS Differentiate Mass-forming Pancreatitis (e.g., Autoimmune Pancreatitis) from Pancreatic Cancer?
Mike Levy

9:50 a.m. – 10:15 a.m.

Is Fatty Pancreas Important and Diagnosable by EUS?
Suresh Chari

10:15 a.m. – 10:30 a.m.

Break

Session 2: EUS in High-risk Patients

Moderators: Linda Lee and Kevin McGrath

10:30 a.m. – 10:55 a.m.

Cystic Lesions: The Role of EUS (With or Without Other Imaging Technologies) For Differentiating Benign and Malignant Cysts
Linda Lee

10:55 a.m. – 11:20 a.m.

Cystic Lesions: Cyst Fluid Analysis in the Differentiation of Benign and Malignant Cysts
Kevin McGrath

11:20 a.m. –11:45 a.m.

New EUS-guided Technologies for Diagnosis of Cystic Lesions
Bill Brugge

11:45 a.m. – 12:10 p.m.

The Role of EUS in Screening for Familial Pancreatic
Mimi Canto

12:10 p.m. – 1:00 p.m.

Lunch (Boxed lunch available for purchase on registration website)

Session 3: EUS-guided Diagnostics and Therapeutics

Moderators: Vikesh Singh and Mark Topazian

1:00 p.m. – 1:20 p.m.

EUS-guided Tissue Acquisition: Pathology Considerations
Thomas Smyrk

1:20 p.m. – 1:40 p.m.

EUS-guided Tissue Acquisition: Endoscopic Considerations
Ken Chang

1:40 p.m. – 2:05 p.m.

EUS-guided Drainage of Pseudocysts and Walled-off Necrosis
Chris Thompson

2:05 p.m. – 2:30 p.m.

EUS-guided Pancreatic Duct Access
Mouen Khashab

2:30 p.m. – 2:55 p.m.

EUS-guided Ablation of Cysts and Tumors
John DeWitt

2:55 p.m. – 3:20 p.m.

Break

Session 4: EUS and New Technologies

Moderators: Dana Andersen and Joo Ha Hwang

3:20 p.m. – 3:45 p.m.

Can Contrast-enhanced EUS, Elastography, and Digital Image Analysis Differentiate Solid Lesions of the Pancreas?
Reiko Ashida

3:45 p.m. – 4:10 p.m.

Ultrasound-guided Microbubble Technique for Molecular Imaging and Drug Delivery
Joo Ha Hwang

4:10 p.m. – 4:35 p.m.

Photoacoustic Imaging of the Pancreas: Lessons Learned from Other Malignancies
Kang Kim

4:35 p.m. – 5:00 p.m.

EUS-Guided Aspiration of Portal Venous Circulating Pancreatic Tumor Cells: Is It Ready for Prime Time?
Irving Waxman

5:00 p.m. – 5:30 p.m.

Group Discussion and Recommendations
Moderators: Linda Lee and Vikesh Singh

5:30 p.m.

Adjournment (Dinner on Your Own)