Remodeling the Hematopoietic Bone Marrow Niche

Event Details

Background

The hematopoietic niche is a solid organ that serves at least two functions: (1) provision of a nurturing environment for long-term maintenance of quiescent hematopoietic stem cells (HSC) and (2) promotion of HSC differentiation via cell-to-cell interactions and local production of growth-promoting cytokines. The goal of this workshop is to learn more about the structure of the bone marrow, particularly the components of the niche that give rise to circulating blood cells and how the niche remodels to adequately respond to changes in environmental cues. Understanding the capacity of the niche to respond may lead to therapeutic interventions to help a patient rapidly return to homeostatic hematopoiesis after a traumatic insult. We also expect to gain a specific understanding of the current scientific and technologic barriers facing the research community in the pursuit of knowledge in this area. The workshop will provide an opportunity for the research community to cooperatively consider the essential next steps for the field.

Registration Deadline

March 29, 2017

Agenda

April 3, 2017

7:00 a.m.

Registration/Poster Setup

7:30 a.m.

Welcoming Remarks
Robert Star, Division of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases

7:45 a.m.

NIDDK Hematology Program
Terry Bishop, National Institute of Diabetes and Digestive and Kidney Diseases

8:00 a.m.

Introduction
Paul Frenette, Albert Einstein College of Medicine

8:30 a.m.

Structure-Function of the Niche
David Scadden, Massachusetts General Hospital

9:00 a.m.

The Niche during Development
Emmanuelle Passegue, Columbia University

9:30 a.m.

Break

9:45 a.m.

Lineage Instructive Differentiation Signals
João Pereira, Yale University School of Medicine

10:15 a.m.

Modeling and Remodeling the Hematopoietic Stem Cell Niche in Zebrafish
Owen Tamplin, University of Illinois at Chicago

10:45 a.m.

Healthy and Malignant Hematopoiesis in the Bone Marrow: Dynamic Cells in an Evolving Environment
Cristina Lo Celso, Imperial College of London

11:15 a.m.

Posters/Lunch Break

1:15 p.m.

Blood Flow Makes Blood Grow: Biomechanical Force in Hematopoiesis
Pamela Wenzel, The University of Texas Health Science Center at Houston

1:45 p.m.

Marrow Cells Mechanosense Rigidity: From Matrix and Nuclei to Phagocytosis
Dennis Discher, University of Pennsylvania

2:15 p.m.

An Engineering Approach to Investigate Niche Regulation of Hematopoietic Stem Cells
Brendan Harley, University of Illinois at Urbana-Champaign

2:45 p.m.

Supporting the Niche: 3D Models of Tissue Remodeling
Jeroen Eyckmans, Boston University/Wyss Institute for Biologically Inspired Engineering

3:15 p.m.

Identifying Gaps in Knowledge
Moderator: Terry Bishop
Audience Participation

4:15 p.m.

Adjournment