Remodeling the Hematopoietic Bone Marrow Niche
The hematopoietic niche is a solid organ that serves at least two functions: (1) provision of a nurturing environment for long-term maintenance of quiescent hematopoietic stem cells (HSC) and (2) promotion of HSC differentiation via cell-to-cell interactions and local production of growth-promoting cytokines. The goal of this workshop is to learn more about the structure of the bone marrow, particularly the components of the niche that give rise to circulating blood cells and how the niche remodels to adequately respond to changes in environmental cues. Understanding the capacity of the niche to respond may lead to therapeutic interventions to help a patient rapidly return to homeostatic hematopoiesis after a traumatic insult. We also expect to gain a specific understanding of the current scientific and technologic barriers facing the research community in the pursuit of knowledge in this area. The workshop will provide an opportunity for the research community to cooperatively consider the essential next steps for the field.
March 29, 2017