Sex and the Kidneys: Sex Differences in Renal Disease
In 1999, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) convened a workshop, Women in Renal Disease, that focused on identifying the unique risks of Chronic Kidney Disease (CKD) and progression to end-stage renal disease present in women across their lifespans. At the conclusion of the workshop, the workshop organizers proposed several avenues of research to advance our understanding of the pathophysiology of sex differences in CKD and improve clinical care of women with CKD. While some advances have been made in both clinical and basic research, much remains poorly understood, both at the molecular and clinical level.
The NIH has recently re-focused the investigator community on the role of sex as a biological variable—requiring all research grant submissions to deliberately consider sex as a modifier of biological response. The purpose of this workshop is to afford the renal research community an opportunity to re-visit the role of sex in disease risk and etiology and take advantage of the advances made in our understanding of sex steroid action in somatic tissues, as well as understanding the role of sex chromosome complement in disease pathophysiology.
Dr. Paul Kimmel, NIDDK/NIH
Dr. Tracy Rankin, NIDDK/NIH
Dr. Ken Korach, NIEHS/NIH
Dr. Louis DePaolo, NICHD/NIH
Dr. Lisa Begg, ORWH/NIH
Dr. Sharon Anderson, Oregon Health Sciences University
Dr. Kathryn Sandberg, Georgetown University
Dr. Jennifer C. Sullivan, Georgia Regents University
Dr. Julie Ingelfinger, Harvard University
July 07, 2017