Event Details
Agenda
Event Details
Background
Many studies of the intestinal microbiome, whether in vitro, in animal models, or in humans report only minimal information on dietary components even though there is substantial evidence that diet modulates composition of the microbiota. Although many aspects of microbiome studies show improved quality control over time, this has not always extended to diet.
Meeting Objectives
The purpose of this workshop is to improve rigor and reproducibility in research on the colonic microbiome, identify important dietary information that should be reported and parameters to consider in design of studies, particularly for clinical studies on diet and the intestinal microbiome. A summary for the research community will be published in a peer-reviewed journal.
Organizing Committee
Christopher Lynch, Office of Nutrition/NIH
Cindy Davis, Office of Dietary Supplements/NIH
Robert Karp, NIDDK/NIH
David Klurfeld, Agricultural Research Service/USDA
Sponsors
USDA/Agricultural Research Service
International Life Sciences Institute
Registration Deadline
Registration Is FULL;
In-person registration is FULL;
Registration for web-ex participation is FULL.
Agenda
June 13, 2017
- 8:45 a.m. – 9:00 a.m.
- Welcome and Introductions
David Klurfeld, USDA ARS
Gregory G. Germino, M.D., Deputy Director, NIDDK
Session I: Characterization of dietary fibers and other nutrients that feed the microbiome
- 9:00 a.m. – 9:35 a.m.
- Keynote Talk: Chemical and physical characteristics of dietary fibers that affect their utilization by the gut microbiota and the host
George Fahey, University of Illinois
- 9:45 a.m. – 10:05 a.m.
- The broad range of structures of dietary fibers and their specificity to bacterial fermentation
Bruce Hamaker, Purdue University
- 10:15 a.m. – 10:35 a.m.
- Fiber-microbiome effects on health and disease: connecting real foods with specific microbial responses
Eric Martens, University of Michigan
- 10:45 a.m. – 11:00 a.m.
- Break
Session II: Animal Models
- 11:00 a.m. – 11:35 a.m.
- Keynote Talk: Diet-microbiota dynamics: leveraging animal models to hasten translatable discovery
Justin Sonnenburg
- 11:45 a.m. – 12:05 p.m.
- The role of gut microbial and host circadian rhythms in metabolic health and disease
Eugene Chang, University of Chicago
- 12:15 p.m. – 1:15 p.m.
- Lunch
- 1:15 p.m. – 1:35 p.m.
- Prebiotic action of food polyphenols on gut microbiota to alleviate obesity-linked inflammatory diseases
Andre Marette, University of Laval
- 1:45 p.m. – 2:05 p.m.
- Food additives and microbiota interactions in the etiology of intestinal inflammation
Benoit Chassaing, Georgia State University
- 2:15 p.m. – 2:35 p.m.
- Utility of Non-Rodent Models for Gastrointestinal Microbiome Research
Kelly Swanson, University of Illinois
- 2:45 p.m. – 3:00 p.m.
- Break
- 3:00 p.m. – 4:30 p.m.
- General Discussion on nutrients affecting microbiome and animal models
June 14, 2017
- 8:45 a.m. – 9:00 a.m.
- Welcome and Introductions
David Klurfeld, USDA ARS
Griffin P. Rodgers, M.D., M.A.C.P., Director, NIDDK
Session III: In Vitro Models
- 9:00 a.m. – 9:20 a.m.
- Culturing gut microbial ecosystems in vitro: using bioreactors as model systems
Emma Allen-Vercoe, University of Guelph
- 9:30 a.m. – 9:50 a.m.
- Effect of host diet on fecal fermentation outcomes
Devin Rose, University of Nebraska
- 10:00 a.m. – 10:30 a.m.
- General Discussion on in vitro models
- 10:30 a.m. – 10:45 a.m.
- Break
Session IV: Human Studies
- 10:45 a.m. – 11:20 a.m.
- Keynote Talk: Impact of diet on the human gut microbiome and its metabolome: relevance to health and disease
Gary Wu
- 11:30 a.m. – 11:50 a.m.
- What are the ideal fiber requirements for humans?
Stephen O’Keefe, University of Pittsburgh
- 12:00 p.m. – 12:20 p.m.
- Effect of diet on gut microbiota
Maria Saarela, VTT Finland
- 12:30 p.m. – 1:30 p.m.
- Lunch
- 1:30 p.m. – 1:50 p.m.
- Nutrients vs diets: using controlled feeding studies to evaluate diet-microbiome interactions in humans
Johanna Lampe, Fred Hutchinson Cancer Center
- 2:00 p.m. – 2:20 p.m.
- Beyond dietary fiber: foods, food additives, and supplements that alter gut bacteria
Joanne Slavin, University of Minnesota
- 2:30 p.m. – 2:50 p.m.
- Regulatory considerations in diet and microbiome studies
Barbara Schneeman, FDA (retired)
- 3:00 p.m. – 4:30 p.m.
- General Discussion: identification of critical dietary issues for design and reporting, terminology (e.g., fiber, prebiotics), research gaps that should be addressed in all studies of diet and gut microbiome, any issues remaining from previous discussions. Challenges in relating models to human situation.
