Event Details
Agenda
Abstracts
Event Details
Background
Autophagy is a carefully choreographed cellular response to stress and environmental changes. The cell creates specific structures to facilitate targeted degradation of components in lysosomes, thereby recycling materials and adjusting cellular contents to suit the new environmental conditions. In recent years, researchers have implicated disruptions of autophagy in numerous diseases within the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) mission. These include cystinosis, the systemic amyloidoses, tuberous sclerosis, acute tubule necrosis, and ciliopathies. The purpose of this conference is to bring together autophagy researchers and those working on NIDDK-relevant disease biology to explore potential common mechanisms and to discuss potential therapeutic development strategies. If successful, this meeting will promote new collaborations and avenues of investigation that identify novel diagnostic tools and new interventions and improve clinical outcomes for diseases relevant to the NIDDK’s mission.
Organizing Committee
External Organizers
Emery Bresnick, Ph.D., University of Wisconsin–Madison
Ana Maria Cuervo, M.D., Ph.D., Albert Einstein College of Medicine
Elizabeth P. Henske, M.D., Harvard Medical School
Gur P. Kaushal, Ph.D., University of Arkansas for Medical Sciences
NIH Organizers
Bonnie Burgess-Beusse, Ph.D., NIDDK, Division of Digestive Diseases and Nutrition
Carol Renfrew Haft, Ph.D., NIDDK, Division of Diabetes, Endocrinology, and Metabolic Diseases
Paul Kimmel, M.D., NIDDK, Division of Kidney, Urologic, and Hematologic Diseases (KUH)
Rebekah Rasooly, Ph.D., NIDDK, KUH
Cindy Roy, Ph.D., NIDDK, KUH
Stefan Maas, Ph.D., National Institute of General Medical Sciences, Division of Genetics and Developmental Biology, Developmental and Cellular Processes Branch
José Velázquez, Ph.D., National Institute on Aging, Division of Aging Biology
Registration Deadline
February 26, 2018
Agenda
March 8, 2018
- 7:30 a.m.
- Registration and Poster Setup
- 8:00 a.m.
- Welcome and Introduction
Robert Star, M.D., Director, Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH)
- 8:15 a.m.
- NIDDK Goals and Logistics
Cindy Roy, Ph.D., NIDDK, NIH
Session 1: Autophagy 101: Classic and Alternative Pathways
Moderator: Stefan Maas, Ph.D., National Institute of General Medical Sciences, NIH
- 8:30 a.m.
- Mechanism and Regulation of Macroautophagy in Yeast
Dan Klionsky, Ph.D., University of Michigan
- 9:00 a.m.
- Non-canonical Autophagy Mediates Immunosuppression during Challenge
Jennifer Martinez, Ph.D., National Institute of Environmental Health Sciences, NIH
- 9:30 a.m.
- Secretory Autophagy
Susan Ferro-Novick, Ph.D., University of California, San Diego
- 10:00 a.m.
- Break
Session 2: Autophagy in Aging
Moderator: José Velázquez, Ph.D., National Institute on Aging, NIH
- 10:30 a.m.
- Selective Mammalian Autophagy and Aging
Ana Maria Cuervo, M.D., Ph.D., Albert Einstein College of Medicine
- 11:00 a.m.
- Lessons from Long-lived C. elegans
Malene Hansen, Ph.D., Sanford Burnham Prebys Medical Discovery Institute
- 11:30 a.m.
- Autophagy in AKI and Aging
Joseph Bonventre, M.D., Ph.D., Brigham and Women’s Hospital, Harvard Medical School
- 12:00 p.m.
- Lunch
- 1:00 p.m.
- Poster Session
Session 3: Junior Investigator “Lightning” Poster Presentations
Moderator: Rebekah Rasooly, Ph.D., National Institute of Nursing Research, NIH
- 2:00 p.m.
- Lysosomal Nitrosative Stress Contributes to Hepatic Insulin Resistance in Obesity
Ling Yang, Ph.D., Assistant Professor, The University of Iowa Carver College of Medicine
- 2:15 p.m.
- Ablation of Adipocytes Autophagy Induces Insulin Resistance and Reveals New Roles for Lipid Peroxides and Nrf2 Signaling in Adipose-Liver Crosstalk
Karla Pires, Ph.D., Postdoctoral Fellow, The University of Utah
- 2:30 p.m.
- p62/SQSTM1 Maintains Redox Homeostasis and Mitochondrial Integrity to Support Renal Disease in Tuberous Sclerosis Complex (TSC)
Hilaire Lam, Ph.D., Instructor, Brigham and Women’s Hospital, Harvard Medical School
- 2:45 p.m.
- Mitochondrial Fission Determines the Selectivity of Mitophagy
Jonathon Burman, Ph.D., Assistant Professor, University of Florida
Session 4: Autophagy as a Signaling Node
Moderator: Carol Haft, Ph.D., NIDDK
- 3:00 p.m.
- Mechanisms Regulating Selective Autophagy
J. Wade Harper, Ph.D., Harvard Medical School
- 3:30 p.m.
- Molecular and Cellular Transitions Governing Erythrocyte Development
Emery Bresnick, Ph.D., University of Wisconsin–Madison
- 4:00 p.m.
- ULK/Atg1 at the Intersection of Macromolecular Complex Disassembly and Degradation
Mondira Kundu, M.D., Ph.D., St. Jude Children’s Research Hospital
- 4:30 p.m.
- Discovery of Novel Regulators of Autophagy in Animals
Eric Baehrecke, Ph.D., University of Massachusetts Medical School
- 5:00 p.m.
- Dinner on your own
March 9, 2018
- 8:00 a.m.
- Registration and Poster Setup
- 8:30 a.m.
- Welcome
Griffin P. Rodgers, M.D., MACP, Director, NIDDK, NIH
Session 5: Autophagy in Kidney Disease
Moderator: Paul Kimmel, M.D., NIDDK, NIH
- 8:45 a.m.
- Cystinosis and Chaperone-mediated Autophagy
Sergio Catz, Ph.D., The Scripps Research Institute
- 9:15 a.m.
- Autophagy in Renal Tubular Survival and Death in AKI
Gur Kaushal, Ph.D., University of Arkansas for Medical Sciences
- 9:45 a.m.
- Role of Autophagy in Tuberous Sclerosis and Other mTORC1-Hyperactive Diseases
Elizabeth Henske, M.D., Brigham and Women’s Hospital, Dana–Farber Cancer Institute, Harvard Medical School
- 10:15 a.m.
- Break
Session 6: Therapeutic Opportunities
Moderator: Bonnie Burgess-Beusse, Ph.D., NIDDK, NIH
- 10:30 a.m.
- Modulation of Autophagy and Mitophagy during Cardiac Stress Using Beclin Inhibitors and TAT-Beclin 1
Junichi Sadoshima, M.D., Ph.D., Rutgers New Jersey Medical School
- 11:00 a.m.
- Therapeutic Opportunities Following Stimulation of Autophagic and Mitophagic Flux
Toren Finkel, M.D., Ph.D., University of Pittsburgh Medical Center and the University of Pittsburgh
- 11:30 a.m.
- Autophagy and Neurogeneration—Issues and Strategies
David Rubinsztein, Ph.D., University of Cambridge, United Kingdom
- 12:00 p.m.
- Conclusions and Adjournment
Cindy Roy, Ph.D., NIDDK, NIH
- 12:30 p.m.
- Departure with Box Lunches
Abstracts
Submission Deadline
January 25, 2018
Submitting Abstracts
All abstracts must be submitted via email to John Hare of The Scientific Consulting Group, Inc. with “Autophagy in Disease” in the subject line. The body of the email should identify the submitting author and the career development stage of the submitting author: student, fellow, instructor, assistant professor/scientist, etc.
Selected abstracts will be presented in poster form.
Junior-level participants (students, fellows, instructors, and assistant professors) with the highest-scoring abstracts will be eligible for a modest travel award.
Abstract selections and travel award notifications will be made the week of February 26, 2018.
Formatting Requirements
- A completed poster abstract should include a statement of purpose, methods used, and a summary of results in sufficient detail to support the conclusion. Statements such as “results will be described” should be avoided.
- The poster abstract should fit on half of an 8.5" × 11" page. Abstracts should be no longer than 250 words (not including name and affiliation).
- The abstract should be typed single-spaced using 12-point Times New Roman font.
- The title should be boldface and followed by one return.
- The author list (authors’ first and last names, degrees) with institutions listed in a separate paragraph—including city, state, and country—should be followed by one return. The name of the presenting author should be underlined. Provide any grant acknowledgments for your research (e.g., R01-DK13028) at the end of your abstract.
- The abstract file should be saved as: presenting author’s Last name_First word in the title (e.g., Zucker_Effects).
Poster Presentations
Selected poster abstracts will appear in the meeting materials. Each author is allotted a 4-foot-high by 6-foot-wide poster board. The poster session will be held during the lunch break.
If your abstract is selected for a poster presentation, please arrive between 7:00 and 7:30 a.m., March 8, 2018, to mount your poster on the posterboard. Pushpins and Velcro will be provided onsite. You will be responsible for removing and shipping your poster at the end of the meeting. Any remaining posters will be discarded.
If you have any questions about the scientific content of the workshop, please contact Dr. Cindy Roy. For questions/concerns about workshop logistics, please contact Mr. John Hare. We look forward to meeting and working with you. We anticipate a stimulating and productive workshop.
Photography Guidelines
Photography is not allowed where posters are displayed.
